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Protein

Dihydrolipoyl dehydrogenase

Gene

Pcal_1402

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Pcal_1402Imported
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)Imported
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_1402.

Structurei

3D structure databases

ProteinModelPortaliA3MW05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 302FAD/NAD-binding_domInterPro annotationAdd BLAST302
Domaini321 – 429Pyr_redox_dimInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiarCOG01068. Archaea.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiTMSEAVM.
OrthoDBiPOG093Z01YB.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 3 hits.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR001100. Pyr_nuc-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
PIRSFiPIRSF000350. Mercury_reductase_MerA. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

A3MW05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVVVGGGP AGYVAAIRAA QLGAEVTLVE EAHLGGECTN WACIPSKALL
60 70 80 90 100
HMADVFWEVK NSPWARGGVE FDWREAQRAK DAVVARLRGG IEKLLAANGV
110 120 130 140 150
EVVAGKAEPG DGRAVRVGER EVRFDSLVLA TGSLPAPLPG APFGRRVLDT
160 170 180 190 200
RRALALEELP KSLFIVGGGA AGVELAVLFA KLGAEVHLAE AMDRLLPAMD
210 220 230 240 250
KDLGAYLESR LRKLGVKVYT SAAVEKVEEG PRSVKVHLRG GAAEVEYVVV
260 270 280 290 300
AVGRRPNPGP FAKWVGDVAK VDERMWTGVG QIYAAGDVAG PPYFAHKAYA
310 320 330 340 350
QGKVAAENAA GRRSFYVQRH VPSVVFTDPE VVSVGYTEEE ARRAGYEAAS
360 370 380 390 400
VRVPMSAIGR AVAGGRPEGF VKLVFDRKRG VVLGFHGVGP GLSEIAAEAA
410 420 430 440
LAVEFSATVE DLALVIHPHP TVSEALAEAA ELALGKPTHV LKP
Length:443
Mass (Da):46,740
Last modified:April 3, 2007 - v1
Checksum:i36F5856513D93AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA. Translation: ABO08822.1.

Genome annotation databases

EnsemblBacteriaiABO08822; ABO08822; Pcal_1402.
KEGGipcl:Pcal_1402.

Similar proteinsi

Entry informationi

Entry nameiA3MW05_PYRCJ
AccessioniPrimary (citable) accession number: A3MW05
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 27, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported