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Protein

Dihydrolipoyl dehydrogenase

Gene

Pcal_1402

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-1434-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Pcal_1402Imported
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)Imported
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_1402.

Structurei

3D structure databases

ProteinModelPortaliA3MW05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 302302FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini321 – 429109Pyr_redox_dimInterPro annotationAdd
BLAST

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiarCOG01068. Archaea.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiRERWGVK.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

A3MW05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVVVGGGP AGYVAAIRAA QLGAEVTLVE EAHLGGECTN WACIPSKALL
60 70 80 90 100
HMADVFWEVK NSPWARGGVE FDWREAQRAK DAVVARLRGG IEKLLAANGV
110 120 130 140 150
EVVAGKAEPG DGRAVRVGER EVRFDSLVLA TGSLPAPLPG APFGRRVLDT
160 170 180 190 200
RRALALEELP KSLFIVGGGA AGVELAVLFA KLGAEVHLAE AMDRLLPAMD
210 220 230 240 250
KDLGAYLESR LRKLGVKVYT SAAVEKVEEG PRSVKVHLRG GAAEVEYVVV
260 270 280 290 300
AVGRRPNPGP FAKWVGDVAK VDERMWTGVG QIYAAGDVAG PPYFAHKAYA
310 320 330 340 350
QGKVAAENAA GRRSFYVQRH VPSVVFTDPE VVSVGYTEEE ARRAGYEAAS
360 370 380 390 400
VRVPMSAIGR AVAGGRPEGF VKLVFDRKRG VVLGFHGVGP GLSEIAAEAA
410 420 430 440
LAVEFSATVE DLALVIHPHP TVSEALAEAA ELALGKPTHV LKP
Length:443
Mass (Da):46,740
Last modified:April 3, 2007 - v1
Checksum:i36F5856513D93AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA. Translation: ABO08822.1.

Genome annotation databases

EnsemblBacteriaiABO08822; ABO08822; Pcal_1402.
KEGGipcl:Pcal_1402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA. Translation: ABO08822.1.

3D structure databases

ProteinModelPortaliA3MW05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410359.Pcal_1402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO08822; ABO08822; Pcal_1402.
KEGGipcl:Pcal_1402.

Phylogenomic databases

eggNOGiarCOG01068. Archaea.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiRERWGVK.

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-1434-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA3MW05_PYRCJ
AccessioniPrimary (citable) accession number: A3MW05
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.