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Protein

Probable deoxyhypusine synthase

Gene

dys

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.UniRule annotation

Catalytic activityi

[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.UniRule annotation

Cofactori

NAD+UniRule annotation

Pathwayi: eIF5A hypusination

This protein is involved in the pathway eIF5A hypusination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway eIF5A hypusination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei267 – 2671NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-1201-MONOMER.
UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyhypusine synthaseUniRule annotation (EC:2.5.1.46UniRule annotation)
Short name:
DHSUniRule annotation
Gene namesi
Name:dysUniRule annotation
Ordered Locus Names:Pcal_1171
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001431 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Probable deoxyhypusine synthasePRO_1000011353Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_1171.

Structurei

3D structure databases

ProteinModelPortaliA3MVC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the deoxyhypusine synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04142. Archaea.
COG1899. LUCA.
HOGENOMiHOG000228838.
KOiK00809.
OMAiGISKHHA.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS. 1 hit.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.

Sequencei

Sequence statusi: Complete.

A3MVC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREVVELYKR IGGFQALHVA QAYEVLKEAL GEADVRFFSF TGNLVATGLR
60 70 80 90 100
EIIAEALRER LFNVVVTTAG ALDHDIAKAM GASYRPGSFD LDDYELAEKG
110 120 130 140 150
LHRLGNVVIS REEYGPYVEK FVLQRCERLW GRSLATYELA EEFGRDLPED
160 170 180 190 200
SILGAAARAG VKVFVPGIVD GAVGTALLTC NDLARVRRGG ARLVVDVLKD
210 220 230 240 250
EEALREIVHG GKRLAALIVG GGISKHHVIW WAQFKGGLDY VVYISTAVEY
260 270 280 290
DGSLSGARPR EAVSWGKVKP TAKSVYVYAD ATLVLPILLK ALCGK
Length:295
Mass (Da):32,193
Last modified:April 3, 2007 - v1
Checksum:iE2D170672123BA7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA. Translation: ABO08596.1.

Genome annotation databases

EnsemblBacteriaiABO08596; ABO08596; Pcal_1171.
KEGGipcl:Pcal_1171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA. Translation: ABO08596.1.

3D structure databases

ProteinModelPortaliA3MVC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410359.Pcal_1171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO08596; ABO08596; Pcal_1171.
KEGGipcl:Pcal_1171.

Phylogenomic databases

eggNOGiarCOG04142. Archaea.
COG1899. LUCA.
HOGENOMiHOG000228838.
KOiK00809.
OMAiGISKHHA.

Enzyme and pathway databases

UniPathwayiUPA00354.
BioCyciPCAL410359:GIX2-1201-MONOMER.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS. 1 hit.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHYS_PYRCJ
AccessioniPrimary (citable) accession number: A3MVC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.