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A3MV95

- SYE_PYRCJ

UniProt

A3MV95 - SYE_PYRCJ

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPCAL410359:GIX2-1166-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Pcal_1137
    OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
    Taxonomic identifieri410359 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000001431: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Glutamate--tRNA ligasePRO_1000057200Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi410359.Pcal_1137.

    Structurei

    3D structure databases

    ProteinModelPortaliA3MV95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi107 – 11711"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiAFRIIDT.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3MV95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIEEVALKY ALANAVKYGG KADVKAVMAK IMAEVPELRP RAREVKEVVE    50
    AVVARVNAMS LEEQRRLLEE KWPEALEEKR PEQKRPGIEA LPDLPKVKGG 100
    VVVRFAPNPD FVLHLGSARP AILNYAYRLK YGGRFILRFE DTDPRTKRPL 150
    VTEEVNAYEA IREDLRWLGV SWDEEYIQSR RMEVYYDYAK RLLAMGAAYV 200
    DLCRPEEWRR LRNEGRACPH RSQSPEENLE LWDKMLEGRF REGEAVVRIK 250
    TDLSHPDPSV RDWVAFRIID TSKTPHPLVG DKYIVWPTYN FAVSIDDHLM 300
    GVTHVLRAQE HSVNTVKQSY VFKHFGWEQP VTIHFGRLKI EGATLSKSKL 350
    KALKVRYDDP TLPTLAGLRA RGILPEAIWE LILTVGIKPS DSTVALSNLF 400
    ALNRKKIEPV ANRYMYVADP VRLVFEADRE LVAKVPYHPS FRERGERVYR 450
    LGPGRVEVFV QRQDVKEGAV VRLMELANVE IERVEGGVAY GRLHSLSLEE 500
    ARKIGAPIIQ WVVDPVEVRV VRPWAPGRKV EEVGLGEAVL RGVEVGAYAQ 550
    FFRYGFVKKI GPDVFIYVHD 570
    Length:570
    Mass (Da):65,246
    Last modified:April 3, 2007 - v1
    Checksum:iC2C817CE798CA6C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000561 Genomic DNA. Translation: ABO08562.1.
    RefSeqiYP_001056028.1. NC_009073.1.

    Genome annotation databases

    EnsemblBacteriaiABO08562; ABO08562; Pcal_1137.
    GeneIDi4908841.
    KEGGipcl:Pcal_1137.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000561 Genomic DNA. Translation: ABO08562.1 .
    RefSeqi YP_001056028.1. NC_009073.1.

    3D structure databases

    ProteinModelPortali A3MV95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 410359.Pcal_1137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO08562 ; ABO08562 ; Pcal_1137 .
    GeneIDi 4908841.
    KEGGi pcl:Pcal_1137.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi AFRIIDT.

    Enzyme and pathway databases

    BioCyci PCAL410359:GIX2-1166-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 11548 / VA1.

    Entry informationi

    Entry nameiSYE_PYRCJ
    AccessioniPrimary (citable) accession number: A3MV95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3