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Protein
Submitted name:

NAD-dependent epimerase/dehydratase

Gene

Pcal_0885

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881NADCombined sources
Binding sitei137 – 1371NADCombined sources
Binding sitei141 – 1411NADCombined sources
Binding sitei167 – 1671NAD; via amide nitrogenCombined sources
Binding sitei174 – 1741NADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 123NADCombined sources
Nucleotide bindingi31 – 366NADCombined sources
Nucleotide bindingi51 – 522NADCombined sources
Nucleotide bindingi69 – 713NADCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

NADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-905-MONOMER.
BRENDAi5.1.3.2. 7282.

Names & Taxonomyi

Protein namesi
Submitted name:
NAD-dependent epimerase/dehydrataseImported
Gene namesi
Ordered Locus Names:Pcal_0885Imported
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)Imported
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001431 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi148 ↔ 159Combined sources

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_0885.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AW9X-ray2.30A/B/C1-31[»]
A/B/C35-35[»]
A/B/C44-312[»]
3ICPX-ray2.01A1-312[»]
3KO8X-ray1.80A1-312[»]
ProteinModelPortaliA3MUJ4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA3MUJ4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 233231EpimeraseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiarCOG01369. Archaea.
COG0451. LUCA.
HOGENOMiHOG000167994.
KOiK01784.
OMAiDFANTIR.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3MUJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVVTGGAG FIGSHLVDKL VELGYEVVVV DNLSSGRREF VNPSAELHVR
60 70 80 90 100
DLKDYSWGAG IKGDVVFHFA ANPEVRLSTT EPIVHFNENV VATFNVLEWA
110 120 130 140 150
RQTGVRTVVF ASSSTVYGDA DVIPTPEEEP YKPISVYGAA KAAGEVMCAT
160 170 180 190 200
YARLFGVRCL AVRYANVVGP RLRHGVIYDF IMKLRRNPNV LEVLGDGTQR
210 220 230 240 250
KSYLYVRDAV EATLAAWKKF EEMDAPFLAL NVGNVDAVRV LDIAQIVAEV
260 270 280 290 300
LGLRPEIRLV PSTPDGRGWP GDVKYMTLAV TKLMKLTGWR PTMTSAEAVK
310
KTAEDLAKEL WG
Length:312
Mass (Da):34,356
Last modified:April 3, 2007 - v1
Checksum:i66B3F2AE07D0FC0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA. Translation: ABO08311.1.

Genome annotation databases

EnsemblBacteriaiABO08311; ABO08311; Pcal_0885.
KEGGipcl:Pcal_0885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA. Translation: ABO08311.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AW9X-ray2.30A/B/C1-31[»]
A/B/C35-35[»]
A/B/C44-312[»]
3ICPX-ray2.01A1-312[»]
3KO8X-ray1.80A1-312[»]
ProteinModelPortaliA3MUJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410359.Pcal_0885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO08311; ABO08311; Pcal_0885.
KEGGipcl:Pcal_0885.

Phylogenomic databases

eggNOGiarCOG01369. Archaea.
COG0451. LUCA.
HOGENOMiHOG000167994.
KOiK01784.
OMAiDFANTIR.

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-905-MONOMER.
BRENDAi5.1.3.2. 7282.

Miscellaneous databases

EvolutionaryTraceiA3MUJ4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 11548 / VA1Imported.
  2. "Crystal Structure of UDP-galactose 4-epimerase."
    Sakuraba H., Kawai T., Yoneda K., Ohshima T.
    Submitted (JUL-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) IN COMPLEX WITH NAD.
  3. "Crystal structure of UDP-galactose 4-epimerase from the hyperthermophilic archaeon Pyrobaculum calidifontis."
    Sakuraba H., Kawai T., Yoneda K., Ohshima T.
    Arch. Biochem. Biophys. 512:126-134(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH NAD.
  4. "Structure of UDP-galactose 4-epimerase mutant."
    Sakuraba H., Kawai T., Yoneda K., Ohshima T.
    Submitted (MAR-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-31; 35-35 AND 44-312 IN COMPLEX WITH NAD, DISULFIDE BONDS.

Entry informationi

Entry nameiA3MUJ4_PYRCJ
AccessioniPrimary (citable) accession number: A3MUJ4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 16, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.