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A3MU00

- SYL_PYRCJ

UniProt

A3MU00 - SYL_PYRCJ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei641 – 6411ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPCAL410359:GIX2-710-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Pcal_0691
    OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
    Taxonomic identifieri410359 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000001431: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 946946Leucine--tRNA ligasePRO_1000009404Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi410359.Pcal_0691.

    Structurei

    3D structure databases

    ProteinModelPortaliA3MU00.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi638 – 6425"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiHAPFDYL.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3MU00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELAKFFIE VAEKWQRRWA EAKVFEPSPQ PGRPKFFITA AYPYPNGTIH    50
    IGHGRTYLVA DVMARFRRHL GYNVLFPMAF HYTGTPILTI AEVIAAGDKA 100
    VIEEYKEIYG VSDDDIKKMG DPLYLAQYFH RRSKEAMIKF GLGIDWSREF 150
    TTIDPEYQRF IQWQFEKLRK RGLIVRGRHP VGWCPRHQMP VGAHDTKDDK 200
    EPEIGQWTLI YFVDGEGLVY PTATLRPETV PGVTNIWINP DAEYVVAEFE 250
    GRKMVLSKDA AYRLSFQGNV KVIREARGRE FVGRRVLNPV TGEWVPVYEA 300
    KFVDPKVGTG VVMSVPAHAP YDYAALRDMG EVKLIPLIRV EGYGEYPAKE 350
    VVERMGIKSQ TDPALEEATR EVYSAEYTRG VVREDVVDRI APHLPEPARS 400
    MVRAVFKLYF AGRPVKEARE FISKWLAEAG LGGVMYDIMN KPVYCRCGTE 450
    IVVKVLEDQW FINYGERGWK QLARQLVEEM AIIPQEAKAQ FLATIDWLDK 500
    RACARTRGLG TPLPWSQGWV IESLSDSTIY MAFYTVIKKI RALGLRPEQL 550
    TEEFWDYVFL GQGSAAEVAK RIGVDPAALE EIRREFDYWY PLDSRNSGKD 600
    LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD 650
    KAVALYGPDP LRATLAIAAE VEQDLDFRDA EARRNSQQLM SIYNLVQRLA 700
    QSAVEREETW LDKWLISEVA HVLERAREAY EKVRLRQAAV ELLYNAEAVF 750
    SQYLSMVDKP SKSAVEAAKA WVVALEPIVP HFAEELWQIL GGEGFAATAP 800
    WPKLSPDPAA LLAKRYVDML IEDVKNIPAY KAGAKRVAIY VNGNYQWLRA 850
    AVGKDVKAAI EAGAPPQLAK RLVDFAKSMG EEVRGLVERV EQFDEYAALQ 900
    SYKRYVEKAL GVPVDIYKAD DPQAPDLGGK KKAALPLKPG IFIEVG 946
    Length:946
    Mass (Da):107,481
    Last modified:April 3, 2007 - v1
    Checksum:iF0D3BC3EC9CB671B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000561 Genomic DNA. Translation: ABO08117.1.
    RefSeqiWP_011849375.1. NC_009073.1.
    YP_001055583.1. NC_009073.1.

    Genome annotation databases

    EnsemblBacteriaiABO08117; ABO08117; Pcal_0691.
    GeneIDi4908582.
    KEGGipcl:Pcal_0691.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000561 Genomic DNA. Translation: ABO08117.1 .
    RefSeqi WP_011849375.1. NC_009073.1.
    YP_001055583.1. NC_009073.1.

    3D structure databases

    ProteinModelPortali A3MU00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 410359.Pcal_0691.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO08117 ; ABO08117 ; Pcal_0691 .
    GeneIDi 4908582.
    KEGGi pcl:Pcal_0691.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi HAPFDYL.

    Enzyme and pathway databases

    BioCyci PCAL410359:GIX2-710-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 11548 / VA1.

    Entry informationi

    Entry nameiSYL_PYRCJ
    AccessioniPrimary (citable) accession number: A3MU00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3