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A3MU00

- SYL_PYRCJ

UniProt

A3MU00 - SYL_PYRCJ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pcal_0691
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001431: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 946946Leucine--tRNA ligasePRO_1000009404Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_0691.

Structurei

3D structure databases

ProteinModelPortaliA3MU00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiHAPFDYL.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3MU00 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSELAKFFIE VAEKWQRRWA EAKVFEPSPQ PGRPKFFITA AYPYPNGTIH
60 70 80 90 100
IGHGRTYLVA DVMARFRRHL GYNVLFPMAF HYTGTPILTI AEVIAAGDKA
110 120 130 140 150
VIEEYKEIYG VSDDDIKKMG DPLYLAQYFH RRSKEAMIKF GLGIDWSREF
160 170 180 190 200
TTIDPEYQRF IQWQFEKLRK RGLIVRGRHP VGWCPRHQMP VGAHDTKDDK
210 220 230 240 250
EPEIGQWTLI YFVDGEGLVY PTATLRPETV PGVTNIWINP DAEYVVAEFE
260 270 280 290 300
GRKMVLSKDA AYRLSFQGNV KVIREARGRE FVGRRVLNPV TGEWVPVYEA
310 320 330 340 350
KFVDPKVGTG VVMSVPAHAP YDYAALRDMG EVKLIPLIRV EGYGEYPAKE
360 370 380 390 400
VVERMGIKSQ TDPALEEATR EVYSAEYTRG VVREDVVDRI APHLPEPARS
410 420 430 440 450
MVRAVFKLYF AGRPVKEARE FISKWLAEAG LGGVMYDIMN KPVYCRCGTE
460 470 480 490 500
IVVKVLEDQW FINYGERGWK QLARQLVEEM AIIPQEAKAQ FLATIDWLDK
510 520 530 540 550
RACARTRGLG TPLPWSQGWV IESLSDSTIY MAFYTVIKKI RALGLRPEQL
560 570 580 590 600
TEEFWDYVFL GQGSAAEVAK RIGVDPAALE EIRREFDYWY PLDSRNSGKD
610 620 630 640 650
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD
660 670 680 690 700
KAVALYGPDP LRATLAIAAE VEQDLDFRDA EARRNSQQLM SIYNLVQRLA
710 720 730 740 750
QSAVEREETW LDKWLISEVA HVLERAREAY EKVRLRQAAV ELLYNAEAVF
760 770 780 790 800
SQYLSMVDKP SKSAVEAAKA WVVALEPIVP HFAEELWQIL GGEGFAATAP
810 820 830 840 850
WPKLSPDPAA LLAKRYVDML IEDVKNIPAY KAGAKRVAIY VNGNYQWLRA
860 870 880 890 900
AVGKDVKAAI EAGAPPQLAK RLVDFAKSMG EEVRGLVERV EQFDEYAALQ
910 920 930 940
SYKRYVEKAL GVPVDIYKAD DPQAPDLGGK KKAALPLKPG IFIEVG
Length:946
Mass (Da):107,481
Last modified:April 3, 2007 - v1
Checksum:iF0D3BC3EC9CB671B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000561 Genomic DNA. Translation: ABO08117.1.
RefSeqiWP_011849375.1. NC_009073.1.
YP_001055583.1. NC_009073.1.

Genome annotation databases

EnsemblBacteriaiABO08117; ABO08117; Pcal_0691.
GeneIDi4908582.
KEGGipcl:Pcal_0691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000561 Genomic DNA. Translation: ABO08117.1 .
RefSeqi WP_011849375.1. NC_009073.1.
YP_001055583.1. NC_009073.1.

3D structure databases

ProteinModelPortali A3MU00.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 410359.Pcal_0691.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO08117 ; ABO08117 ; Pcal_0691 .
GeneIDi 4908582.
KEGGi pcl:Pcal_0691.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi HAPFDYL.

Enzyme and pathway databases

BioCyci PCAL410359:GIX2-710-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 11548 / VA1.

Entry informationi

Entry nameiSYL_PYRCJ
AccessioniPrimary (citable) accession number: A3MU00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3