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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pcal_0691
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094041 – 946Leucine--tRNA ligaseAdd BLAST946

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_0691

Structurei

3D structure databases

ProteinModelPortaliA3MU00
SMRiA3MU00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A3MU00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELAKFFIE VAEKWQRRWA EAKVFEPSPQ PGRPKFFITA AYPYPNGTIH
60 70 80 90 100
IGHGRTYLVA DVMARFRRHL GYNVLFPMAF HYTGTPILTI AEVIAAGDKA
110 120 130 140 150
VIEEYKEIYG VSDDDIKKMG DPLYLAQYFH RRSKEAMIKF GLGIDWSREF
160 170 180 190 200
TTIDPEYQRF IQWQFEKLRK RGLIVRGRHP VGWCPRHQMP VGAHDTKDDK
210 220 230 240 250
EPEIGQWTLI YFVDGEGLVY PTATLRPETV PGVTNIWINP DAEYVVAEFE
260 270 280 290 300
GRKMVLSKDA AYRLSFQGNV KVIREARGRE FVGRRVLNPV TGEWVPVYEA
310 320 330 340 350
KFVDPKVGTG VVMSVPAHAP YDYAALRDMG EVKLIPLIRV EGYGEYPAKE
360 370 380 390 400
VVERMGIKSQ TDPALEEATR EVYSAEYTRG VVREDVVDRI APHLPEPARS
410 420 430 440 450
MVRAVFKLYF AGRPVKEARE FISKWLAEAG LGGVMYDIMN KPVYCRCGTE
460 470 480 490 500
IVVKVLEDQW FINYGERGWK QLARQLVEEM AIIPQEAKAQ FLATIDWLDK
510 520 530 540 550
RACARTRGLG TPLPWSQGWV IESLSDSTIY MAFYTVIKKI RALGLRPEQL
560 570 580 590 600
TEEFWDYVFL GQGSAAEVAK RIGVDPAALE EIRREFDYWY PLDSRNSGKD
610 620 630 640 650
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD
660 670 680 690 700
KAVALYGPDP LRATLAIAAE VEQDLDFRDA EARRNSQQLM SIYNLVQRLA
710 720 730 740 750
QSAVEREETW LDKWLISEVA HVLERAREAY EKVRLRQAAV ELLYNAEAVF
760 770 780 790 800
SQYLSMVDKP SKSAVEAAKA WVVALEPIVP HFAEELWQIL GGEGFAATAP
810 820 830 840 850
WPKLSPDPAA LLAKRYVDML IEDVKNIPAY KAGAKRVAIY VNGNYQWLRA
860 870 880 890 900
AVGKDVKAAI EAGAPPQLAK RLVDFAKSMG EEVRGLVERV EQFDEYAALQ
910 920 930 940
SYKRYVEKAL GVPVDIYKAD DPQAPDLGGK KKAALPLKPG IFIEVG
Length:946
Mass (Da):107,481
Last modified:April 3, 2007 - v1
Checksum:iF0D3BC3EC9CB671B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA Translation: ABO08117.1

Genome annotation databases

EnsemblBacteriaiABO08117; ABO08117; Pcal_0691
KEGGipcl:Pcal_0691

Similar proteinsi

Entry informationi

Entry nameiSYL_PYRCJ
AccessioniPrimary (citable) accession number: A3MU00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health