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A3MTU7 (IF2P_PYRCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:Pcal_0638
OrganismPyrobaculum calidifontis (strain JCM 11548 / VA1) [Complete proteome] [HAMAP]
Taxonomic identifier410359 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 By similarity. HAMAP-Rule MF_00100

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 592592Probable translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_0000335533

Regions

Nucleotide binding14 – 218GTP By similarity
Nucleotide binding80 – 845GTP By similarity
Nucleotide binding134 – 1374GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
A3MTU7 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 5B7A4F3545646AD1

FASTA59265,291
        10         20         30         40         50         60 
MQQKIRSPFV VVMGHVDVGK TLLLDKIRGT SVAYREPGMI TQHIGMSLVP WPAVEKFAGP 

        70         80         90        100        110        120 
LVDRLKLRGR IWIPGFLFID TPGHAAFSNL RKRGGSVADL AILVVDITSG LEDQGVESLK 

       130        140        150        160        170        180 
LIQSRGVPFV IAANKLDRIY GWKSVENRPF LFAVEEQEWH AVATLEEQIG KLITQLANLG 

       190        200        210        220        230        240 
IDADRYDRVR DFSKQVPIVP TSAVTGEGVA DLLLVLAGVS QRFIPREKLQ VRDGPARGVV 

       250        260        270        280        290        300 
MEVKEERGLG VVADVILYDG KLRKGDVIVT AGLDGSRQAK VRMLIMPKSL EEMRDPEDKF 

       310        320        330        340        350        360 
MAVQEVEAAA GVRVVAEGLE GVVAGAPLLA VWDPKDLPEA LKSVGEEIAE IKIESDKEGV 

       370        380        390        400        410        420 
IVRADTFGTL ESIILFLRQQ GVPVRKADVG PPTHKDVVEA VLSRRKNPAY GAILAFNVKV 

       430        440        450        460        470        480 
PPEVETEAQS SGVKIIRGEI LYRIFDEYVK WSTEVKTKTV EQVLSQLTRP AKIQILPGYV 

       490        500        510        520        530        540 
FRRSDPAIVG VKVLAGTLKP GVTLAKDGRE VGKVMQIQRQ GKPVAEAVAG DEVAISIQGD 

       550        560        570        580        590 
VIVGRQIKEG DVLYVYIPDE QARQWLFRYK QYLRKDEVEA LEEYLKTRKK SA 

« Hide

References

[1]"Complete sequence of Pyrobaculum calidifontis JCM 11548."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Cozen A.E., Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 11548 / VA1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000561 Genomic DNA. Translation: ABO08064.1.
RefSeqYP_001055530.1. NC_009073.1.

3D structure databases

ProteinModelPortalA3MTU7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING410359.Pcal_0638.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO08064; ABO08064; Pcal_0638.
GeneID4908230.
KEGGpcl:Pcal_0638.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000105770.
KOK03243.
OMAIVCVMGH.
ProtClustDBPRK04004.

Enzyme and pathway databases

BioCycPCAL410359:GIX2-656-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_A. IF_2_A.
InterProIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIF2P_PYRCJ
AccessionPrimary (citable) accession number: A3MTU7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries