A3MTU7 (IF2P_PYRCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable translation initiation factor IF-2

Gene names

Name:	infB
Ordered Locus Names:	Pcal_0638

Organism

Pyrobaculum calidifontis (strain JCM 11548 / VA1) [Complete proteome] [HAMAP]

Taxonomic identifier

410359 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum › Pyrobaculum calidifontis

Protein attributes

Sequence length	592 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 By similarity. HAMAP-Rule MF_00100
Sequence similarities	Belongs to the IF-2 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	GTP-binding Nucleotide-binding
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: HAMAP translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 592	592	Probable translation initiation factor IF-2 HAMAP-Rule MF_00100		PRO_0000335533
Regions
	Nucleotide binding	14 – 21	8	GTP By similarity
	Nucleotide binding	80 – 84	5	GTP By similarity
	Nucleotide binding	134 – 137	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3MTU7 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 5B7A4F3545646AD1	FASTA	592	65,291
	10 20 30 40 50 60 MQQKIRSPFV VVMGHVDVGK TLLLDKIRGT SVAYREPGMI TQHIGMSLVP WPAVEKFAGP 70 80 90 100 110 120 LVDRLKLRGR IWIPGFLFID TPGHAAFSNL RKRGGSVADL AILVVDITSG LEDQGVESLK 130 140 150 160 170 180 LIQSRGVPFV IAANKLDRIY GWKSVENRPF LFAVEEQEWH AVATLEEQIG KLITQLANLG 190 200 210 220 230 240 IDADRYDRVR DFSKQVPIVP TSAVTGEGVA DLLLVLAGVS QRFIPREKLQ VRDGPARGVV 250 260 270 280 290 300 MEVKEERGLG VVADVILYDG KLRKGDVIVT AGLDGSRQAK VRMLIMPKSL EEMRDPEDKF 310 320 330 340 350 360 MAVQEVEAAA GVRVVAEGLE GVVAGAPLLA VWDPKDLPEA LKSVGEEIAE IKIESDKEGV 370 380 390 400 410 420 IVRADTFGTL ESIILFLRQQ GVPVRKADVG PPTHKDVVEA VLSRRKNPAY GAILAFNVKV 430 440 450 460 470 480 PPEVETEAQS SGVKIIRGEI LYRIFDEYVK WSTEVKTKTV EQVLSQLTRP AKIQILPGYV 490 500 510 520 530 540 FRRSDPAIVG VKVLAGTLKP GVTLAKDGRE VGKVMQIQRQ GKPVAEAVAG DEVAISIQGD 550 560 570 580 590 VIVGRQIKEG DVLYVYIPDE QARQWLFRYK QYLRKDEVEA LEEYLKTRKK SA

References

[1]

"Complete sequence of Pyrobaculum calidifontis JCM 11548." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Cozen A.E., Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCM 11548 / VA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000561 Genomic DNA. Translation: ABO08064.1.
RefSeq	YP_001055530.1. NC_009073.1.
3D structure databases
ProteinModelPortal	A3MTU7.
ModBase	Search...
Protein-protein interaction databases
STRING	410359.Pcal_0638.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABO08064; ABO08064; Pcal_0638.
GeneID	4908230.
KEGG	pcl:Pcal_0638.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0532.
HOGENOM	HOG000105770.
KO	K03243.
OMA	FRQSKPA.
ProtClustDB	PRK04004.
Enzyme and pathway databases
BioCyc	PCAL410359:GIX2-649-MONOMER.
Family and domain databases
Gene3D	3.40.50.10050. 1 hit.
HAMAP	MF_00100_A. IF-2_A.
InterPro	IPR000795. EF_GTP-bd_dom. IPR005225. Small_GTP-bd_dom. IPR004544. TIF_aIF-2_arc. IPR015760. TIF_IF2. IPR023115. TIF_IF2_dom3. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
PANTHER	PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfam	PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF11987. IF-2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SUPFAM	SSF52156. TIF_IF2_dom3. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00491. aIF-2. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS01176. IF2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF2P_PYRCJ

Accession

Primary (citable) accession number: A3MTU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program