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Protein

Probable translation initiation factor IF-2

Gene

infB

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218GTPUniRule annotation
Nucleotide bindingi80 – 845GTPUniRule annotation
Nucleotide bindingi134 – 1374GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-656-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Pcal_0638
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592Probable translation initiation factor IF-2PRO_0000335533Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_0638.

Structurei

3D structure databases

ProteinModelPortaliA3MTU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 226222tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 218G1By similarity
Regioni39 – 435G2By similarity
Regioni80 – 834G3By similarity
Regioni134 – 1374G4By similarity
Regioni202 – 2043G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000105770.
KOiK03243.
OMAiFRQSKPA.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A.
InterProiIPR000795. EF_GTP-bd_dom.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3MTU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQKIRSPFV VVMGHVDVGK TLLLDKIRGT SVAYREPGMI TQHIGMSLVP
60 70 80 90 100
WPAVEKFAGP LVDRLKLRGR IWIPGFLFID TPGHAAFSNL RKRGGSVADL
110 120 130 140 150
AILVVDITSG LEDQGVESLK LIQSRGVPFV IAANKLDRIY GWKSVENRPF
160 170 180 190 200
LFAVEEQEWH AVATLEEQIG KLITQLANLG IDADRYDRVR DFSKQVPIVP
210 220 230 240 250
TSAVTGEGVA DLLLVLAGVS QRFIPREKLQ VRDGPARGVV MEVKEERGLG
260 270 280 290 300
VVADVILYDG KLRKGDVIVT AGLDGSRQAK VRMLIMPKSL EEMRDPEDKF
310 320 330 340 350
MAVQEVEAAA GVRVVAEGLE GVVAGAPLLA VWDPKDLPEA LKSVGEEIAE
360 370 380 390 400
IKIESDKEGV IVRADTFGTL ESIILFLRQQ GVPVRKADVG PPTHKDVVEA
410 420 430 440 450
VLSRRKNPAY GAILAFNVKV PPEVETEAQS SGVKIIRGEI LYRIFDEYVK
460 470 480 490 500
WSTEVKTKTV EQVLSQLTRP AKIQILPGYV FRRSDPAIVG VKVLAGTLKP
510 520 530 540 550
GVTLAKDGRE VGKVMQIQRQ GKPVAEAVAG DEVAISIQGD VIVGRQIKEG
560 570 580 590
DVLYVYIPDE QARQWLFRYK QYLRKDEVEA LEEYLKTRKK SA
Length:592
Mass (Da):65,291
Last modified:April 2, 2007 - v1
Checksum:i5B7A4F3545646AD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA. Translation: ABO08064.1.
RefSeqiWP_011849322.1. NC_009073.1.
YP_001055530.1. NC_009073.1.

Genome annotation databases

EnsemblBacteriaiABO08064; ABO08064; Pcal_0638.
GeneIDi4908230.
KEGGipcl:Pcal_0638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA. Translation: ABO08064.1.
RefSeqiWP_011849322.1. NC_009073.1.
YP_001055530.1. NC_009073.1.

3D structure databases

ProteinModelPortaliA3MTU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410359.Pcal_0638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO08064; ABO08064; Pcal_0638.
GeneIDi4908230.
KEGGipcl:Pcal_0638.

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000105770.
KOiK03243.
OMAiFRQSKPA.

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-656-MONOMER.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A.
InterProiIPR000795. EF_GTP-bd_dom.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 11548 / VA1.

Entry informationi

Entry nameiIF2P_PYRCJ
AccessioniPrimary (citable) accession number: A3MTU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 19, 2008
Last sequence update: April 2, 2007
Last modified: March 3, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.