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A3MSH1

- A3MSH1_PYRCJ

UniProt

A3MSH1 - A3MSH1_PYRCJ

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Protein
Submitted name:

Polyprenyl synthetase

Gene

Pcal_0150

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441PhosphateImported
Binding sitei76 – 761PhosphateImported
Binding sitei79 – 791Acetate
Binding sitei83 – 831Acetate
Binding sitei93 – 931PhosphateImported

GO - Molecular functioni

  1. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Isoprene biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-152-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Polyprenyl synthetaseImported
Gene namesi
Ordered Locus Names:Pcal_0150Imported
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)Imported
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001431: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_0150.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DHDX-ray1.65A1-334[»]
4GP1X-ray1.94A1-334[»]
4GP2X-ray2.00A/B1-334[»]
ProteinModelPortaliA3MSH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0142.
HOGENOMiHOG000009101.
KOiK13787.
OMAiAKWGVLS.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3MSH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVVSRLHQK YGAEVEKALV RYLSIGLAED FREAVLYQVK TGGKRLRPLL
60 70 80 90 100
TLAAAEAVSG QWRPALPAAA IVELIHNYSL IYDDIIDRGD VRRGLPTVRK
110 120 130 140 150
AFGDNAAILV GIWYREAIEE AVLDTPKPTL FAKEVAEVIK AIDEGERLDI
160 170 180 190 200
LFEAAGRSDP YFVQARWREV TLDDYIKMVS LKTGALIAAA AKWGVLSVSD
210 220 230 240 250
DRGLAEAAWN FGMAAGVAFQ IIDDVLDIYG DPKKFGKEIG KDIKEHKRGN
260 270 280 290 300
AVVAVALSHL GEGERRRLLE ILAREVVEEA DVREAVALLD SVGAREEALR
310 320 330
LAARYREEAE RHLAKIPNNG TLKELLDFIV AREY
Length:334
Mass (Da):37,046
Last modified:April 3, 2007 - v1
Checksum:iEA143E3BBA183661
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000561 Genomic DNA. Translation: ABO07588.1.
RefSeqiYP_001055054.1. NC_009073.1.

Genome annotation databases

EnsemblBacteriaiABO07588; ABO07588; Pcal_0150.
GeneIDi4909904.
KEGGipcl:Pcal_0150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000561 Genomic DNA. Translation: ABO07588.1 .
RefSeqi YP_001055054.1. NC_009073.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DHD X-ray 1.65 A 1-334 [» ]
4GP1 X-ray 1.94 A 1-334 [» ]
4GP2 X-ray 2.00 A/B 1-334 [» ]
ProteinModelPortali A3MSH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 410359.Pcal_0150.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO07588 ; ABO07588 ; Pcal_0150 .
GeneIDi 4909904.
KEGGi pcl:Pcal_0150.

Phylogenomic databases

eggNOGi COG0142.
HOGENOMi HOG000009101.
KOi K13787.
OMAi AKWGVLS.

Enzyme and pathway databases

BioCyci PCAL410359:GIX2-152-MONOMER.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view ]
PANTHERi PTHR12001. PTHR12001. 1 hit.
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 11548 / VA1Imported.
  2. "Crystal Structure of Isoprenoid Synthase from Pyrobaculum Calidifontis."
    Patskovsky Y., Toro R., Bhosle R., Hillerich B., Seidel R.D., Washington E., Scott Glenn A., Chowdury S., Evans B., Hammonds J., Zencheck W.D., Imker H.J., Poulter C.D., Gerlt J.A., Almo S.C.
    Submitted (AUG-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
  3. "Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily."
    Wallrapp F.H., Pan J.J., Ramamoorthy G., Almonacid D.E., Hillerich B.S., Seidel R., Patskovsky Y., Babbitt P.C., Almo S.C., Jacobson M.P., Poulter C.D.
    Proc. Natl. Acad. Sci. U.S.A. 110:E1196-E1202(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).

Entry informationi

Entry nameiA3MSH1_PYRCJ
AccessioniPrimary (citable) accession number: A3MSH1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3