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A3MSH1

- A3MSH1_PYRCJ

UniProt

A3MSH1 - A3MSH1_PYRCJ

Protein
Submitted name:

Polyprenyl synthetase

Gene

Pcal_0150

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441PhosphateImported
    Binding sitei76 – 761PhosphateImported
    Binding sitei79 – 791Acetate
    Binding sitei83 – 831Acetate
    Binding sitei93 – 931PhosphateImported

    GO - Molecular functioni

    1. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciPCAL410359:GIX2-152-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Polyprenyl synthetaseImported
    Gene namesi
    Ordered Locus Names:Pcal_0150Imported
    OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)Imported
    Taxonomic identifieri410359 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000001431: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi410359.Pcal_0150.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DHDX-ray1.65A1-334[»]
    4GP1X-ray1.94A1-334[»]
    4GP2X-ray2.00A/B1-334[»]
    ProteinModelPortaliA3MSH1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0142.
    HOGENOMiHOG000009101.
    KOiK13787.
    OMAiAKWGVLS.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PANTHERiPTHR12001. PTHR12001. 1 hit.
    PfamiPF00348. polyprenyl_synt. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3MSH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVVSRLHQK YGAEVEKALV RYLSIGLAED FREAVLYQVK TGGKRLRPLL    50
    TLAAAEAVSG QWRPALPAAA IVELIHNYSL IYDDIIDRGD VRRGLPTVRK 100
    AFGDNAAILV GIWYREAIEE AVLDTPKPTL FAKEVAEVIK AIDEGERLDI 150
    LFEAAGRSDP YFVQARWREV TLDDYIKMVS LKTGALIAAA AKWGVLSVSD 200
    DRGLAEAAWN FGMAAGVAFQ IIDDVLDIYG DPKKFGKEIG KDIKEHKRGN 250
    AVVAVALSHL GEGERRRLLE ILAREVVEEA DVREAVALLD SVGAREEALR 300
    LAARYREEAE RHLAKIPNNG TLKELLDFIV AREY 334
    Length:334
    Mass (Da):37,046
    Last modified:April 3, 2007 - v1
    Checksum:iEA143E3BBA183661
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000561 Genomic DNA. Translation: ABO07588.1.
    RefSeqiYP_001055054.1. NC_009073.1.

    Genome annotation databases

    EnsemblBacteriaiABO07588; ABO07588; Pcal_0150.
    GeneIDi4909904.
    KEGGipcl:Pcal_0150.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000561 Genomic DNA. Translation: ABO07588.1 .
    RefSeqi YP_001055054.1. NC_009073.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DHD X-ray 1.65 A 1-334 [» ]
    4GP1 X-ray 1.94 A 1-334 [» ]
    4GP2 X-ray 2.00 A/B 1-334 [» ]
    ProteinModelPortali A3MSH1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 410359.Pcal_0150.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO07588 ; ABO07588 ; Pcal_0150 .
    GeneIDi 4909904.
    KEGGi pcl:Pcal_0150.

    Phylogenomic databases

    eggNOGi COG0142.
    HOGENOMi HOG000009101.
    KOi K13787.
    OMAi AKWGVLS.

    Enzyme and pathway databases

    BioCyci PCAL410359:GIX2-152-MONOMER.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    PANTHERi PTHR12001. PTHR12001. 1 hit.
    Pfami PF00348. polyprenyl_synt. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 11548 / VA1Imported.
    2. "Crystal Structure of Isoprenoid Synthase from Pyrobaculum Calidifontis."
      Patskovsky Y., Toro R., Bhosle R., Hillerich B., Seidel R.D., Washington E., Scott Glenn A., Chowdury S., Evans B., Hammonds J., Zencheck W.D., Imker H.J., Poulter C.D., Gerlt J.A., Almo S.C.
      Submitted (AUG-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
    3. "Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily."
      Wallrapp F.H., Pan J.J., Ramamoorthy G., Almonacid D.E., Hillerich B.S., Seidel R., Patskovsky Y., Babbitt P.C., Almo S.C., Jacobson M.P., Poulter C.D.
      Proc. Natl. Acad. Sci. U.S.A. 110:E1196-E1202(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).

    Entry informationi

    Entry nameiA3MSH1_PYRCJ
    AccessioniPrimary (citable) accession number: A3MSH1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3