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A3MQJ7 (ATPA1_BURM7) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha 1
EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha 1
F-ATPase subunit alpha 1
Gene names
Name:atpA1
Ordered Locus Names:BMA10247_3013
OrganismBurkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP]
Taxonomic identifier320389 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513ATP synthase subunit alpha 1 HAMAP MF_01346
PRO_0000339019

Regions

Nucleotide binding169 – 1768ATP By similarity

Sites

Site3731Required for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A3MQJ7 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: CE603CEBB6B09ADB

FASTA51355,926
        10         20         30         40         50         60 
MQLNPSEISE LIKSRIQGLE ASADVRNQGT VISVTDGIVR IHGLSDVMQG EMLEFPGNTF 

        70         80         90        100        110        120 
GLALNLERDS VGAVILGEYE HISEGDIVKT TGRILEVPVG PELVGRVLDA LGNPIDGKGP 

       130        140        150        160        170        180 
VNAKLTDAIE KIAPGVIWRK SVSQPVQTGL KSIDSMVPIG RGQRELIIGD RQCGKTAVAI 

       190        200        210        220        230        240 
DTIINQKGKD LICIYVAIGQ KASSIMNVVR KLEETGALEY TIVVAASASE SAAMQYLAPY 

       250        260        270        280        290        300 
AGCTMGEYFR DRGQDALIIY DDLTKQAWAY RQISLLLRRP PGREAYPGDV FYLHSRLLER 

       310        320        330        340        350        360 
AARVSEEYVE KFTNGEVKGK SGSLTALPVI ETQAGDVTAF VPTNVISITD GQIFLETDLF 

       370        380        390        400        410        420 
NAGIRPAINA GVSVSRVGGA AQTKVVKKLS GGIRTDLAQY RELAAFAQFA SDLDEATRKQ 

       430        440        450        460        470        480 
LERGRRVTEL LKQPQYQPLQ VWELAVSLFS ANNGYLDDLD VKDVLPFEKG LREYLKTSHA 

       490        500        510 
DLIKRIEDTK DLSKDDESAL HAALKDFKKS GAY

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 10247.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000548 Genomic DNA. Translation: ABO06879.1.
RefSeqYP_001082533.1. NC_009080.1.

3D structure databases

ProteinModelPortalA3MQJ7.
SMRA3MQJ7. Positions 29-509.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3MQJ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4894704.
GenomeReviewsGene locus BMA10247_3013 in contig CP000548_GR.
KEGGbmn:BMA10247_3013.
PATRIC19148358. VBIBurMal96640_5210.
TIGRBMA10247_3013.

Phylogenomic databases

HOGENOMHBG565875.
OMAGSDRDIK.
ProtClustDBPRK09281.

Enzyme and pathway databases

BioCycBMAL320389:BMA10247_3013-MONOMER.

Family and domain databases

HAMAPMF_01346. ATP_synth_alpha_bact.
[Tree]
InterProIPR020003. ATPase_a/bsu_AS.
IPR005294. ATPase_F1-cplx_asu.
IPR018118. ATPase_F1/A1-cplx_a/bsu_N.
IPR023366. ATPase_F1/A1-cplx_a_su_N.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
[Graphical view]
Gene3DG3DSA:2.40.30.20. G3DSA:2.40.30.20. 1 hit.
KOK02111.
PANTHERPTHR15184:SF3. ATPase_F1_a. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF47917. ATPase_a/b_C. 1 hit.
SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMsTIGR00962. AtpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATPA1_BURM7
AccessionPrimary (citable) accession number: A3MQJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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