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A3MNA4 (HEMH_BURM7) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:BMA10247_2211
OrganismBurkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP]
Taxonomic identifier320389 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Ferrochelatase HAMAP MF_00323
PRO_1000019279

Sites

Metal binding2261Iron By similarity
Metal binding3071Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A3MNA4 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 6F6301D1C0F66FE8

FASTA36740,518
        10         20         30         40         50         60 
MSFDSVPRHA LSMRFDLEPP SHASAAHRVA VLLVNLGTPD APTPRAVRRY LAQFLSDPRV 

        70         80         90        100        110        120 
VEIPQLVWQV ILCTLILPLR GRASAKKYAA VWLPEGSPLR VYTERQVESV KPLFAANGYR 

       130        140        150        160        170        180 
VIVDYAMRYG TPSIADVLAQ LKRAGAERVL LLPMYPQYSS STTATAFDAA FAALGRMRNQ 

       190        200        210        220        230        240 
PEVRTVRHYA DHPAYIHALA EQVRQYWAAH GRPAFDAGDK LVLSFHGVPK RTLDLGDPYH 

       250        260        270        280        290        300 
DQCQQTAALL MSALGLTTFE CRVTFQSRFG KAEWLQPYTA PTLKELGAAG VRRADVFCPG 

       310        320        330        340        350        360 
FTADCLETIE EIGIEVRDEF VHGGGKEFHR IPCLNASPAW IAALGEIAAE NLQGWPVRVA 


MAPEAVS

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 10247.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000548 Genomic DNA. Translation: ABO03971.1.
RefSeqYP_001081740.1. NC_009080.1.

3D structure databases

ProteinModelPortalA3MNA4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3MNA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4894084.
GenomeReviewsGene locus BMA10247_2211 in contig CP000548_GR.
KEGGbmn:BMA10247_2211.
PATRIC19146797. VBIBurMal96640_4434.
TIGRBMA10247_2211.

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycBMAL320389:BMA10247_2211-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_BURM7
AccessionPrimary (citable) accession number: A3MNA4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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