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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Burkholderia mallei (strain NCTC 10247)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBMAL320389:GH97-1845-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation)
Alternative name(s):
Ap4A hydrolaseUniRule annotation
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation
Diadenosine tetraphosphataseUniRule annotation
Gene namesi
Name:apaHUniRule annotation
Ordered Locus Names:BMA10247_1853
OrganismiBurkholderia mallei (strain NCTC 10247)
Taxonomic identifieri320389 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Bis(5'-nucleosyl)-tetraphosphatase, symmetricalPRO_1000012046Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA3MMA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.
OrthoDBiEOG66B3WP.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

A3MMA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNFSSSPPI AFGDLQGCHA AYRQLFDTLA PAADTPLWFA GDLVNRGPAS
60 70 80 90 100
LATLREIAAL GERAIAVLGN HDLHLLAVAA GIRTLKPGDT IGEILDAPDA
110 120 130 140 150
DDLIEWVRHR PFAHFERGML MVHAGLLPQW DAALALELAD ELQRALRASN
160 170 180 190 200
WRDTLRSLYG NDPNCWSPDL KHADRLRVAF NAFTRIRFCT PEGAMEFRAN
210 220 230 240 250
GGPAAAPAGY LPWFDAPGRK TADVTVVFGH WAALGLMLRE NLVALDSGCV
260 270 280
WGNRLSAVRL ADDPAARVVT QVACERCGAA DE
Length:282
Mass (Da):30,572
Last modified:April 3, 2007 - v1
Checksum:i665D4AA4D13EDF9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000548 Genomic DNA. Translation: ABO06890.1.
RefSeqiWP_004186146.1. NZ_CP007802.1.

Genome annotation databases

EnsemblBacteriaiABO06890; ABO06890; BMA10247_1853.
KEGGibmaz:BM44_1349.
bmn:BMA10247_1853.
PATRICi19146093. VBIBurMal96640_4088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000548 Genomic DNA. Translation: ABO06890.1.
RefSeqiWP_004186146.1. NZ_CP007802.1.

3D structure databases

ProteinModelPortaliA3MMA4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO06890; ABO06890; BMA10247_1853.
KEGGibmaz:BM44_1349.
bmn:BMA10247_1853.
PATRICi19146093. VBIBurMal96640_4088.

Phylogenomic databases

HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.
OrthoDBiEOG66B3WP.

Enzyme and pathway databases

BioCyciBMAL320389:GH97-1845-MONOMER.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 10247.

Entry informationi

Entry nameiAPAH_BURM7
AccessioniPrimary (citable) accession number: A3MMA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: November 11, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.