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A3MLY6

- A3MLY6_BURM7

UniProt

A3MLY6 - A3MLY6_BURM7

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Protein

Succinylglutamate desuccinylase

Gene
astE, BMA10247_1731
Organism
Burkholderia mallei (strain NCTC 10247)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Transforms N(2)-succinylglutamate into succinate and glutamate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotationSAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi70 – 701Zinc By similarityUniRule annotation
Metal bindingi73 – 731Zinc By similarityUniRule annotation
Metal bindingi166 – 1661Zinc By similarityUniRule annotation
Active sitei229 – 2291 By similarityUniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
  2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
  2. arginine catabolic process to succinate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Arginine metabolismUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBMAL320389:GH97-1723-MONOMER.
UniPathwayiUPA00185; UER00283.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
Gene namesi
Name:astEUniRule annotationImported
Ordered Locus Names:BMA10247_1731Imported
OrganismiBurkholderia mallei (strain NCTC 10247)Imported
Taxonomic identifieri320389 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002284: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi320389.BMA10247_1731.

Structurei

3D structure databases

ProteinModelPortaliA3MLY6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2988.
HOGENOMiHOG000280300.
KOiK05526.
OMAiDHAVRHL.
OrthoDBiEOG613070.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF017020. AstE. 1 hit.
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

Sequencei

Sequence statusi: Complete.

A3MLY6-1 [UniParc]FASTAAdd to Basket

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MTSSADSGRD AAWLDDFLAL TLAGDAPPAE AGECAARAVR WRWLGDGLLR    50
LEPADAAQRM QSVLVSAGVH GDETAPIELL STLVRDIARG ALPLRCRLLV 100
ALGNPGAMRA GERYLDDDLN RLFGGRHAQL AASREAPRAA QLEAAAALFF 150
STAGRARGAR WHIDMHTAIR TSVFEQFALL PHTGEPPTRT MFEWLGEAQI 200
AAVLLHTTKG STFSHFTAQA CGALACTLEL GKVMPFGAND LSRFAPADAA 250
VRRLVSGRRD APRGALPRAF TVVDQITKQS DALELFVAND VPNFTPFARG 300
TLLARDGDYR YAVRHEQERI VFPNPSVKPG LRAGLLVIET TRDTHAALA 349
Length:349
Mass (Da):37,622
Last modified:April 3, 2007 - v1
Checksum:i1D1F32BB7F0A1AF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000548 Genomic DNA. Translation: ABO06240.1.
RefSeqiYP_001081272.1. NC_009080.1.

Genome annotation databases

EnsemblBacteriaiABO06240; ABO06240; BMA10247_1731.
GeneIDi4891618.
KEGGibmn:BMA10247_1731.
PATRICi19145858. VBIBurMal96640_3975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000548 Genomic DNA. Translation: ABO06240.1 .
RefSeqi YP_001081272.1. NC_009080.1.

3D structure databases

ProteinModelPortali A3MLY6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320389.BMA10247_1731.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO06240 ; ABO06240 ; BMA10247_1731 .
GeneIDi 4891618.
KEGGi bmn:BMA10247_1731.
PATRICi 19145858. VBIBurMal96640_3975.

Phylogenomic databases

eggNOGi COG2988.
HOGENOMi HOG000280300.
KOi K05526.
OMAi DHAVRHL.
OrthoDBi EOG613070.

Enzyme and pathway databases

UniPathwayi UPA00185 ; UER00283 .
BioCyci BMAL320389:GH97-1723-MONOMER.

Family and domain databases

HAMAPi MF_00767. Arg_catab_AstE.
InterProi IPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view ]
Pfami PF04952. AstE_AspA. 1 hit.
[Graphical view ]
PIRSFi PIRSF017020. AstE. 1 hit.
TIGRFAMsi TIGR03242. arg_catab_astE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 10247Imported.

Entry informationi

Entry nameiA3MLY6_BURM7
AccessioniPrimary (citable) accession number: A3MLY6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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