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A3MLY6

- A3MLY6_BURM7

UniProt

A3MLY6 - A3MLY6_BURM7

Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Burkholderia mallei (strain NCTC 10247)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Transforms N(2)-succinylglutamate into succinate and glutamate.UniRule annotationSAAS annotation

    Catalytic activityi

    N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi70 – 701ZincUniRule annotation
    Metal bindingi73 – 731ZincUniRule annotation
    Metal bindingi166 – 1661ZincUniRule annotation
    Active sitei229 – 2291UniRule annotation

    GO - Molecular functioni

    1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
    2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
    2. arginine catabolic process to succinate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Arginine metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBMAL320389:GH97-1723-MONOMER.
    UniPathwayiUPA00185; UER00283.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
    Gene namesi
    Name:astEUniRule annotationImported
    Ordered Locus Names:BMA10247_1731Imported
    OrganismiBurkholderia mallei (strain NCTC 10247)Imported
    Taxonomic identifieri320389 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002284: Chromosome I

    Interactioni

    Protein-protein interaction databases

    STRINGi320389.BMA10247_1731.

    Structurei

    3D structure databases

    ProteinModelPortaliA3MLY6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2988.
    HOGENOMiHOG000280300.
    KOiK05526.
    OMAiDHAVRHL.
    OrthoDBiEOG613070.

    Family and domain databases

    HAMAPiMF_00767. Arg_catab_AstE.
    InterProiIPR007036. Aste_AspA.
    IPR016681. SuccinylGlu_desuccinylase.
    [Graphical view]
    PfamiPF04952. AstE_AspA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017020. AstE. 1 hit.
    TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3MLY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSADSGRD AAWLDDFLAL TLAGDAPPAE AGECAARAVR WRWLGDGLLR    50
    LEPADAAQRM QSVLVSAGVH GDETAPIELL STLVRDIARG ALPLRCRLLV 100
    ALGNPGAMRA GERYLDDDLN RLFGGRHAQL AASREAPRAA QLEAAAALFF 150
    STAGRARGAR WHIDMHTAIR TSVFEQFALL PHTGEPPTRT MFEWLGEAQI 200
    AAVLLHTTKG STFSHFTAQA CGALACTLEL GKVMPFGAND LSRFAPADAA 250
    VRRLVSGRRD APRGALPRAF TVVDQITKQS DALELFVAND VPNFTPFARG 300
    TLLARDGDYR YAVRHEQERI VFPNPSVKPG LRAGLLVIET TRDTHAALA 349
    Length:349
    Mass (Da):37,622
    Last modified:April 3, 2007 - v1
    Checksum:i1D1F32BB7F0A1AF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000548 Genomic DNA. Translation: ABO06240.1.
    RefSeqiYP_001081272.1. NC_009080.1.

    Genome annotation databases

    EnsemblBacteriaiABO06240; ABO06240; BMA10247_1731.
    GeneIDi4891618.
    KEGGibmn:BMA10247_1731.
    PATRICi19145858. VBIBurMal96640_3975.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000548 Genomic DNA. Translation: ABO06240.1 .
    RefSeqi YP_001081272.1. NC_009080.1.

    3D structure databases

    ProteinModelPortali A3MLY6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320389.BMA10247_1731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO06240 ; ABO06240 ; BMA10247_1731 .
    GeneIDi 4891618.
    KEGGi bmn:BMA10247_1731.
    PATRICi 19145858. VBIBurMal96640_3975.

    Phylogenomic databases

    eggNOGi COG2988.
    HOGENOMi HOG000280300.
    KOi K05526.
    OMAi DHAVRHL.
    OrthoDBi EOG613070.

    Enzyme and pathway databases

    UniPathwayi UPA00185 ; UER00283 .
    BioCyci BMAL320389:GH97-1723-MONOMER.

    Family and domain databases

    HAMAPi MF_00767. Arg_catab_AstE.
    InterProi IPR007036. Aste_AspA.
    IPR016681. SuccinylGlu_desuccinylase.
    [Graphical view ]
    Pfami PF04952. AstE_AspA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017020. AstE. 1 hit.
    TIGRFAMsi TIGR03242. arg_catab_astE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 10247Imported.

    Entry informationi

    Entry nameiA3MLY6_BURM7
    AccessioniPrimary (citable) accession number: A3MLY6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3