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A3ML78 (KDSA_BURM7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene names
Name:kdsA
Ordered Locus Names:BMA10247_1467
OrganismBurkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP]
Taxonomic identifier320389 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056

Pathway

Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056

Subcellular location

Cytoplasm By similarity HAMAP MF_00056.

Sequence similarities

Belongs to the KdsA family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-deoxy-8-phosphooctulonate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2842842-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056
PRO_1000003328

Sequences

Sequence LengthMass (Da)Tools
A3ML78 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 152D3B5E894DEFBD

FASTA28430,570
        10         20         30         40         50         60 
MNLAGFEVGL DKPFFLIAGT CVVESEQMTI DTAGRLKEIC ATLGVPFIYK SSYDKANRSS 

        70         80         90        100        110        120 
GKSFRGLGMD EGLRILAEVK RQLNVPVLTD VHEIDEIAPV AAVVDVLQTP AFLCRQTDFI 

       130        140        150        160        170        180 
RACAQSGKPV NIKKGQFLAP HDMKNVIDKA RDAARDAGLS EDRFMACERG VSFGYNNLVS 

       190        200        210        220        230        240 
DMRSLAIMRE TGAPVVFDAT HSVQLPGGQG TSSGGQREFV PVLARAALAT GVAGLFMETH 

       250        260        270        280 
PNPAEAKSDG PNAVPLGRMA ALLETLVTLD RAVKRVPFLE NDFN

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 10247.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000548 Genomic DNA. Translation: ABO06827.1.
RefSeqYP_001081014.1. NC_009080.1.

3D structure databases

ProteinModelPortalA3ML78.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3ML78.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4893367.
GenomeReviewsGene locus BMA10247_1467 in contig CP000548_GR.
KEGGbmn:BMA10247_1467.
PATRIC19145340. VBIBurMal96640_3719.
TIGRBMA10247_1467.

Phylogenomic databases

HOGENOMHBG575990.
OMACAKLNIP.
ProtClustDBPRK05198.

Enzyme and pathway databases

BioCycBMAL320389:BMA10247_1467-MONOMER.

Family and domain databases

HAMAPMF_00056. KDO8P_synth.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01627.
PANTHERPTHR21057:SF2. KDO8P_synthase. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01362. KDO8P_synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSA_BURM7
AccessionPrimary (citable) accession number: A3ML78
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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