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Reviewed, UniProtKB/Swiss-Prot A3MI87 (ILVC_BURM7)

Last modified November 25, 2008. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name: ilvC
Ordered Locus Names: BMA10247_0398
OrganismBurkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP]
Taxonomic identifier320389 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ketol-acid reductoisomerase
PRO_1000050486

Sites

Active site1071 Potential

Sequences

Sequence LengthMass (Da)Tools
A3MI87-1 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 7F06A53243A44DA0

FASTA33836,267
        10         20         30         40         50         60 
MKVFYDKDAD LSLIKGKQVT IIGYGSQGHA HALNLKDSGV NVTVGLRRGG ASWSKAENAG 

        70         80         90        100        110        120 
LAVKEVAEAV KGADVVMMLL PDEQIAAVYA QEVHANIKEG AALAFAHGFN VHYGQVIPRA 

       130        140        150        160        170        180 
DLDVIMVAPK APGHTVRGTY AQGGGVPHLI AVAQDKSGAA RDIALSYAAA NGGGRAGIIE 

       190        200        210        220        230        240 
TNFREETETD LFGEQAVLCG GTVELIKAGF ETLVEAGYAP EMAYFECLHE LKLIVDLIYE 

       250        260        270        280        290        300 
GGIANMNYSI SNNAEYGEYV TGPRVVTEET KKAMKQCLTD IQTGEYAKSF ILENKAGAPT 

       310        320        330 
LQSRRRLTAE HQIEQVGSKL RAMMPWIAKN KLVDQSKN 

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References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000548 Genomic DNA. Translation: ABO07112.1.
RefSeqYP_001079973.1.

3D structure databases

SMRA3MI87. Positions 1-327.
ModBaseSearch...

Genome annotation databases

GeneID4894061.
GenomeReviewsGene locus BMA10247_0398 in contig CP000548_GR.
KEGGbmn:BMA10247_0398.
TIGRBMA10247_0398.

Family and domain databases

HAMAPMF_00435.
[Tree]
InterProIPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013116. IlvN.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_BURM7
AccessionPrimary (citable) accession number: A3MI87
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: November 25, 2008
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents