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A3MI45 (HEM6_BURM7) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3
Gene names
Name:hemF
Ordered Locus Names:BMA10247_0356
OrganismBurkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP]
Taxonomic identifier320389 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333

Subunit structure

Homodimer By similarity. HAMAP MF_00333

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: EC

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
PRO_1000019458

Regions

Region55 – 6410Important for dimerization By similarity
Region115 – 1173Substrate binding By similarity
Region247 – 28236Important for dimerization By similarity
Region265 – 2706Substrate binding By similarity

Sites

Active site1131Proton donor By similarity
Binding site991Substrate By similarity
Site1821Important for dimerization By similarity

Sequences

Sequence LengthMass (Da)Tools
A3MI45 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 095790F8C2662CD0

FASTA30734,596
        10         20         30         40         50         60 
MTDSTYDVNR VRAYLQGLQM RIADALGAFD GTPLAADTWR RGPGERLRGG GCTRILEAGG 

        70         80         90        100        110        120 
FFERAGIGFS DVAGDALPPS ANASRPQLAG RGFEALGVSL VLHPRNPYCP TVHMNVRMLI 

       130        140        150        160        170        180 
ATKPGEAPVF WFGGGMDLTP IYGFEEDARH FHRTCRAALE PFGAELYPRF KKWCDDYFFL 

       190        200        210        220        230        240 
KHRNEARGIG GIFFDDFSEL GFERSFEMLQ SVGDAFLPSY LPIVERRRDT PYGERERAFQ 

       250        260        270        280        290        300 
AYRRGRYVEF NLVFDRGTLF GLQSGGRTES ILLSMPPTAG WRYDWHPDPG TPEARLQSEF 


LVPRDWA

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 10247.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000548 Genomic DNA. Translation: ABO07246.1.
RefSeqYP_001079931.1. NC_009080.1.

3D structure databases

ProteinModelPortalA3MI45.
SMRA3MI45. Positions 5-307.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3MI45.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4893647.
GenomeReviewsGene locus BMA10247_0356 in contig CP000548_GR.
KEGGbmn:BMA10247_0356.
PATRIC19143143. VBIBurMal96640_2641.
TIGRBMA10247_0356.

Phylogenomic databases

HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Enzyme and pathway databases

BioCycBMAL320389:BMA10247_0356-MONOMER.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM6_BURM7
AccessionPrimary (citable) accession number: A3MI45
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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