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A3MHJ7 (F16PA_BURM7) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Gene names
Name:fbp
Ordered Locus Names:BMA10247_0157
OrganismBurkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP]
Taxonomic identifier320389 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855

Subunit structure

Homotetramer By similarity. HAMAP MF_01855

Subcellular location

Cytoplasm Potential HAMAP MF_01855.

Sequence similarities

Belongs to the FBPase class 1 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855
PRO_0000364492

Regions

Region119 – 1224Substrate binding By similarity

Sites

Metal binding941Magnesium 1 By similarity
Metal binding1161Magnesium 1 By similarity
Metal binding1161Magnesium 2 By similarity
Metal binding1181Magnesium 1; via carbonyl oxygen By similarity
Metal binding1191Magnesium 2 By similarity
Metal binding2821Magnesium 2 By similarity
Binding site2101Substrate By similarity
Binding site2761Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A3MHJ7 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: B4964A195E9A89F8

FASTA33837,377
        10         20         30         40         50         60 
MSITRRTTLS KYLIEQQRET HNLPADLRLL IEVVARACKA ISYNVSKGAL GDALGTAGSE 

        70         80         90        100        110        120 
NVQGEVQKKL DILSNEILLD ANEWGGNLAA MASEEMETFF PIPANYPRGE YLLVFDPLDG 

       130        140        150        160        170        180 
SSNIDVNVSI GTIFSVLRCP DGQQATEQSF LQPGTEQVAA GYAVYGPQTV FVLTTGNGVN 

       190        200        210        220        230        240 
CFTLDREVGS WVLTQSNLRI PEDTREYAIN ASNARHWYEP VKRYIDELNA GAEGPRGENF 

       250        260        270        280        290        300 
NMRWIASMVA DVHRILNRGG IFMYPADKRT PDRPGKLRLM YEANPMSFIV EQAGGAATTG 

       310        320        330 
LKRILDVQPT GLHQRVPVIL GSKNEVERVA RYHEQAQS

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 10247.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000548 Genomic DNA. Translation: ABO04678.1.
RefSeqYP_001079733.1. NC_009080.1.

3D structure databases

ProteinModelPortalA3MHJ7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3MHJ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4892307.
GenomeReviewsGene locus BMA10247_0157 in contig CP000548_GR.
KEGGbmn:BMA10247_0157.
PATRIC19142721. VBIBurMal96640_2425.
TIGRBMA10247_0157.

Phylogenomic databases

HOGENOMHBG731261.
OMAHWEAPVQ.
ProtClustDBPRK09293.

Enzyme and pathway databases

BioCycBMAL320389:BMA10247_0157-MONOMER.

Family and domain databases

HAMAPMF_01855. FBPase_class1.
[Tree]
InterProIPR000146. FBPase_class-1/SBPase.
[Graphical view]
KOK03841.
PANTHERPTHR11556. In_FB_phphtase. 1 hit.
PfamPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFPIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSPR00115. F16BPHPHTASE.
PROSITEPS00124. FBPASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF16PA_BURM7
AccessionPrimary (citable) accession number: A3MHJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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