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A3MGM7 (A3MGM7_BURM7) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH-1 EMBL ABO02715.1
Synonyms:ispH1 HAMAP MF_00191
Ordered Locus Names:BMA10247_A2242
OrganismBurkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP] EMBL ABO02715.1
Taxonomic identifier320389 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
A3MGM7 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 6C48EAB68E5EDC18

FASTA31333,697
        10         20         30         40         50         60 
MRVILAQPRG FCAGVVRAIG IVERALQQNG APVYVRHEIV HNRHVVENLR NKGARFVEEL 

        70         80         90        100        110        120 
DEVPHGAVAI FSAHGVAQTV EQDAQARGLD VLDATCPLVT KVHVQGRQYV AAGRRLILIG 

       130        140        150        160        170        180 
HAGHPEVEGT IGQIPAEVIL VQSEAEVDTL TLPADTPVAY VTQTTLSVDD TRGIIEALQR 

       190        200        210        220        230        240 
RFTDIVGPDT RDICYATQNR QAAVRELSEQ VDVLLVVGAT NSSNSNRLRE IGTESGVPSY 

       250        260        270        280        290        300 
LVADGSEVRA EWFANARTVG LTAGASAPEE MVEDVIAALR ALGPLEVATM SGREEKVEFK 

       310 
LPAKLTQAVA REV

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NCTC 10247 EMBL ABO02715.1.
[2]Brinkac L.M., Harkins D.M., Shrivastava S., Durkin A.S., Sutton G.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NCTC 10247 EMBL ABO02715.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000547 Genomic DNA. Translation: ABO02715.1.
RefSeqYP_001079413.1. NC_009079.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA3MGM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4889536.
GenomeReviewsGene locus BMA10247_A2242 in contig CP000547_GR.
KEGGbmn:BMA10247_A2242.
PATRIC19142089. VBIBurMal96640_2113.
TIGRBMA10247_A2242.

Phylogenomic databases

HOGENOMHBG335228.
OMAHNQGKRY.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA3MGM7_BURM7
AccessionPrimary (citable) accession number: A3MGM7
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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