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A3MFQ4 (TRPC_BURM7) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Indole-3-glycerol phosphate synthase

Short name=IGPS
EC=4.1.1.48
Gene names
Name:trpC
Ordered Locus Names:BMA10247_A1913
OrganismBurkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP]
Taxonomic identifier320389 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134

Sequence similarities

Belongs to the TrpC family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionindole-3-glycerol-phosphate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134
PRO_1000018454

Sequences

Sequence LengthMass (Da)Tools
A3MFQ4 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: B72B5A0EA837CB29

FASTA26128,383
        10         20         30         40         50         60 
MSDILDKIIA VKREEIAAAL ESAPLEELKV QASARDSRDF VGALRDKHAA GHAAVIAEVK 

        70         80         90        100        110        120 
KASPSKGVLR EHFVPADIAR SYAQHGAACL SVLTDERFFQ GSARYLEQAR AACTLPVLRK 

       130        140        150        160        170        180 
DFIVDAYQLL EARAMGADAI LLIAAALDTP LMIDLEAYAH SLGLAVLVEV HNRGELDEAL 

       190        200        210        220        230        240 
KLKTPFVGIN NRNLRTFETT IDTTLGMLDA IPDDRIVVTE SGILSRADVE RMEAAGVHTF 

       250        260 
LVGEAFMRAE NPGAELARMF F 

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 10247.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000547 Genomic DNA. Translation: ABO03008.1.
RefSeqYP_001079090.1. NC_009079.1.

3D structure databases

ProteinModelPortalA3MFQ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING320389.BMA10247_A1913.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO03008; ABO03008; BMA10247_A1913.
GeneID4890926.
KEGGbmn:BMA10247_A1913.
PATRIC19141429. VBIBurMal96640_1784.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0134.
HOGENOMHOG000230463.
KOK01609.
OMARKDFMFE.
OrthoDBEOG6WT8JX.
ProtClustDBPRK00278.

Enzyme and pathway databases

BioCycBMAL320389:GH97-5432-MONOMER.
UniPathwayUPA00035; UER00043.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00134_B. IGPS_B.
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPC_BURM7
AccessionPrimary (citable) accession number: A3MFQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways