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Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Burkholderia mallei (strain NCTC 10247)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciBMAL320389:GH97-5432-MONOMER.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthaseUniRule annotation (EC:4.1.1.48UniRule annotation)
Short name:
IGPSUniRule annotation
Gene namesi
Name:trpCUniRule annotation
Ordered Locus Names:BMA10247_A1913
OrganismiBurkholderia mallei (strain NCTC 10247)
Taxonomic identifieri320389 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002284 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Indole-3-glycerol phosphate synthasePRO_1000018454Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi320389.BMA10247_A1913.

Structurei

3D structure databases

ProteinModelPortaliA3MFQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000230463.
KOiK01609.
OMAiDIAQSYA.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_B. IGPS_B.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3MFQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDILDKIIA VKREEIAAAL ESAPLEELKV QASARDSRDF VGALRDKHAA
60 70 80 90 100
GHAAVIAEVK KASPSKGVLR EHFVPADIAR SYAQHGAACL SVLTDERFFQ
110 120 130 140 150
GSARYLEQAR AACTLPVLRK DFIVDAYQLL EARAMGADAI LLIAAALDTP
160 170 180 190 200
LMIDLEAYAH SLGLAVLVEV HNRGELDEAL KLKTPFVGIN NRNLRTFETT
210 220 230 240 250
IDTTLGMLDA IPDDRIVVTE SGILSRADVE RMEAAGVHTF LVGEAFMRAE
260
NPGAELARMF F
Length:261
Mass (Da):28,383
Last modified:April 3, 2007 - v1
Checksum:iB72B5A0EA837CB29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000547 Genomic DNA. Translation: ABO03008.1.
RefSeqiYP_001079090.1. NC_009079.1.

Genome annotation databases

EnsemblBacteriaiABO03008; ABO03008; BMA10247_A1913.
GeneIDi4890926.
KEGGibmn:BMA10247_A1913.
PATRICi19141429. VBIBurMal96640_1784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000547 Genomic DNA. Translation: ABO03008.1.
RefSeqiYP_001079090.1. NC_009079.1.

3D structure databases

ProteinModelPortaliA3MFQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi320389.BMA10247_A1913.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO03008; ABO03008; BMA10247_A1913.
GeneIDi4890926.
KEGGibmn:BMA10247_A1913.
PATRICi19141429. VBIBurMal96640_1784.

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000230463.
KOiK01609.
OMAiDIAQSYA.
OrthoDBiEOG6WT8JX.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00043.
BioCyciBMAL320389:GH97-5432-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_B. IGPS_B.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 10247.

Entry informationi

Entry nameiTRPC_BURM7
AccessioniPrimary (citable) accession number: A3MFQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: February 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.