A3MFQ4 (TRPC_BURM7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BMA10247_A1913

Organism

Burkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP]

Taxonomic identifier

320389 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › Burkholderia mallei

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134		PRO_1000018454

Sequences

	Sequence		Length	Mass (Da)
	A3MFQ4 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: B72B5A0EA837CB29	FASTA	261	28,383
	10 20 30 40 50 60 MSDILDKIIA VKREEIAAAL ESAPLEELKV QASARDSRDF VGALRDKHAA GHAAVIAEVK 70 80 90 100 110 120 KASPSKGVLR EHFVPADIAR SYAQHGAACL SVLTDERFFQ GSARYLEQAR AACTLPVLRK 130 140 150 160 170 180 DFIVDAYQLL EARAMGADAI LLIAAALDTP LMIDLEAYAH SLGLAVLVEV HNRGELDEAL 190 200 210 220 230 240 KLKTPFVGIN NRNLRTFETT IDTTLGMLDA IPDDRIVVTE SGILSRADVE RMEAAGVHTF 250 260 LVGEAFMRAE NPGAELARMF F

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 10247.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000547 Genomic DNA. Translation: ABO03008.1.
RefSeq	YP_001079090.1. NC_009079.1.
3D structure databases
ProteinModelPortal	A3MFQ4.
ModBase	Search...
Protein-protein interaction databases
STRING	320389.BMA10247_A1913.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABO03008; ABO03008; BMA10247_A1913.
GeneID	4890926.
KEGG	bmn:BMA10247_A1913.
PATRIC	19141429. VBIBurMal96640_1784.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HOG000230463.
KO	K01609.
OMA	LEYAVPH.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	BMAL320389:GH97-5433-MONOMER.
UniPathway	UPA00035; UER00043.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00134_B. IGPS_B.
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BURM7

Accession

Primary (citable) accession number: A3MFQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program