A3MEC7 (A3MEC7_BURM7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Choline dehydrogenase HAMAP MF_00750
Short name=CDH HAMAP MF_00750
Short name=CHD HAMAP MF_00750
EC=1.1.99.1 HAMAP MF_00750

Gene names

Name:	betA HAMAP MF_00750
Ordered Locus Names:	BMA10247_A1428

Organism

Burkholderia mallei (strain NCTC 10247) [Complete proteome] [HAMAP] EMBL ABO02176.1

Taxonomic identifier

320389 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750 SAAS SAAS007867
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750 SAAS SAAS007867
Cofactor	FAD By similarity. HAMAP MF_00750 SAAS SAAS007867
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750 SAAS SAAS007867
Sequence similarities	Belongs to the GMC oxidoreductase family. HAMAP MF_00750

Ontologies

Keywords
Ligand	FAD HAMAP MF_00750 SAAS SAAS011533 Flavoprotein HAMAP MF_00750 SAAS SAAS011533
Molecular function	Oxidoreductase HAMAP MF_00750 SAAS SAAS007867 EMBL ABO02176.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	7 – 36	30	FAD By similarity HAMAP MF_00750
Sites
	Active site	474	1	By similarity HAMAP MF_00750

Sequences

	Sequence		Length	Mass (Da)
	A3MEC7 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: AE6B071643D1D025	FASTA	565	62,636
	10 20 30 40 50 60 MTTREFDYII CGAGSAGNVL ATRLTEDPGV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG 70 80 90 100 110 120 RRYNWAYETD PEPHMNHRRM ECGRGKGLGG SSLINGMCYI RGNALDYDNW ATHKGLEDWA 130 140 150 160 170 180 YLDCLPYFRK AETRDVGPND YHGGDGPVSV TTSKPGVNPL FEAMVEAGVQ AGYPRTDDLN 190 200 210 220 230 240 GYQQEGFGPM DRTVTPRGRR ASTARGYLDQ ARARPNLEIV THALADRILF SGKRATGVTF 250 260 270 280 290 300 LHGSARVTAH ARREVLVCSG AIASPQLLQR SGVGPGEWLR ELDIPVVLDL PGVGRNLQDH 310 320 330 340 350 360 LEMYIQFECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI RTRDDDPWPN 370 380 390 400 410 420 IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSCGRVKL KSRDPHAHPS ILFNYMAEAL 430 440 450 460 470 480 DWREFRDAIR ATREIMRQPA LDRFRGRELN PGADLKSDNE LDTFVRARAE TAFHPSCSCK 490 500 510 520 530 540 MGYDDMAVVD NEGRVHGIDG LRVVDASIMP IITTGNLNAP TIMIAEKIAD RIRKHKPLER 550 560 SNAQYYVANG APARGGKPAR APAVV

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: NCTC 10247 EMBL ABO02176.1.
[2]	Brinkac L.M., Harkins D.M., Shrivastava S., Durkin A.S., Sutton G. Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: NCTC 10247 EMBL ABO02176.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000547 Genomic DNA. Translation: ABO02176.1.
RefSeq	YP_001078613.1. NC_009079.1.
3D structure databases
ProteinModelPortal	A3MEC7.
ModBase	Search...
Protein-protein interaction databases
STRING	A3MEC7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4891088.
GenomeReviews	Gene locus BMA10247_A1428 in contig CP000547_GR.
KEGG	bmn:BMA10247_A1428.
PATRIC	19140515. VBIBurMal96640_1328.
TIGR	BMA10247_A1428.
Phylogenomic databases
HOGENOM	HBG734713.
OMA	RSTAPYY.
ProtClustDB	PRK02106.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A3MEC7_BURM7

Accession

Primary (citable) accession number: A3MEC7

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)