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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Burkholderia mallei (strain NCTC 10247)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. no protein annotated in this organism
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton acceptorUniRule annotation1
Active sitei60Proton acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpAUniRule annotation
Ordered Locus Names:BMA10247_A0531
OrganismiBurkholderia mallei (strain NCTC 10247)
Taxonomic identifieri320389 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000181751 – 271Tryptophan synthase alpha chainAdd BLAST271

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA3MBU6.
SMRiA3MBU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223815.
KOiK01695.
OMAiDYPPEEC.

Family and domain databases

CDDicd04724. Tryptophan_synthase_alpha. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
PfamiView protein in Pfam
PF00290. Trp_syntA. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiView protein in PROSITE
PS00167. TRP_SYNTHASE_ALPHA. 1 hit.

Sequencei

Sequence statusi: Complete.

A3MBU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIQNTFAA LAAQGRKGLI PFITAGDPDP AKTVELMHAL AEGGADVIEL
60 70 80 90 100
GVPFSDPMAD GPVIQRSSER ALAKGVTLHS VLDDVKRFRA RDQKTPVVLM
110 120 130 140 150
GYANPIERMG ADAFAAAARD AGVDGVLVVD YPPEESHDFA AKMRAAGIDP
160 170 180 190 200
IFLLAPTSTD DRIAAVGQVA SGYVYYVSLK GVTGAANLDV SSIAGKIPAI
210 220 230 240 250
KSRVPLPVGV GFGIRDAATA RAVAEVADAV VIGSRLVQLL EQAVPERAAA
260 270
ELAGFVAELR AAIDGAAKPA A
Length:271
Mass (Da):27,978
Last modified:April 3, 2007 - v1
Checksum:iAC4B83AA542695CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000547 Genomic DNA. Translation: ABO01893.1.
RefSeqiWP_004187543.1. NZ_CP007801.1.

Genome annotation databases

EnsemblBacteriaiABO01893; ABO01893; BMA10247_A0531.
KEGGibmaz:BM44_3232.
bmn:BMA10247_A0531.
PATRICifig|320389.8.peg.3629.

Similar proteinsi

Entry informationi

Entry nameiTRPA_BURM7
AccessioniPrimary (citable) accession number: A3MBU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families