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A3MBD3

- GCH4_BURM7

UniProt

A3MBD3 - GCH4_BURM7

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia mallei (strain NCTC 10247)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBMAL320389:GH97-3900-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:BMA10247_A0366
OrganismiBurkholderia mallei (strain NCTC 10247)
Taxonomic identifieri320389 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002284: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269GTP cyclohydrolase FolE2PRO_0000316527Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi320389.BMA10247_A0366.

Structurei

3D structure databases

ProteinModelPortaliA3MBD3.
SMRiA3MBD3. Positions 21-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3MBD3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLMNPEFAM PDVQSTVDTR QMPIQRVGVR AVRHPLTVRT AEGETQATVG
60 70 80 90 100
TWNLDVHLPA DQKGTHMSRF VALLEERGGP LTADAFRTML ATMLEKLEAR
110 120 130 140 150
AGRIEVSFPY FVNKTAPVSG VRSLLDYEVT LTGDVRDGLT RVFAKVLVPV
160 170 180 190 200
TSLCPCSKKI SQYGAHNQRS HVTIDAELAA DVPVEDLIRI AEEEASCELW
210 220 230 240 250
GLLKRPDEKF VTERAYENPK FVEDLVRDVA RRLDADERIV AYVLEAENFE
260
SIHNHSAYAL IERDKRRGA
Length:269
Mass (Da):30,188
Last modified:February 5, 2008 - v2
Checksum:i832F04704D584F29
GO

Sequence cautioni

The sequence ABO02353.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000547 Genomic DNA. Translation: ABO02353.1. Different initiation.
RefSeqiYP_001077569.1. NC_009079.1.

Genome annotation databases

EnsemblBacteriaiABO02353; ABO02353; BMA10247_A0366.
GeneIDi4889713.
KEGGibmn:BMA10247_A0366.
PATRICi19138527. VBIBurMal96640_0343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000547 Genomic DNA. Translation: ABO02353.1 . Different initiation.
RefSeqi YP_001077569.1. NC_009079.1.

3D structure databases

ProteinModelPortali A3MBD3.
SMRi A3MBD3. Positions 21-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320389.BMA10247_A0366.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO02353 ; ABO02353 ; BMA10247_A0366 .
GeneIDi 4889713.
KEGGi bmn:BMA10247_A0366.
PATRICi 19138527. VBIBurMal96640_0343.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BMAL320389:GH97-3900-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 10247.

Entry informationi

Entry nameiGCH4_BURM7
AccessioniPrimary (citable) accession number: A3MBD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3