A3MAA0 (ILVD_ACIBT) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 41.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Dihydroxy-acid dehydratase Short name=DAD EC=4.2.1.9 | ||||
| Gene names |
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| Organism | Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 400667 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex |
Protein attributes
| Sequence length | 609 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012 |
| Cofactor | Binds 1 4Fe-4S cluster Potential. |
| Pathway | Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012 |
| Sequence similarities | Belongs to the IlvD/Edd family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis |
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW dihydroxy-acid dehydratase activityInferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 609 | 609 | Dihydroxy-acid dehydratase HAMAP MF_00012 | PRO_1000089361 | |||||
Sites | |||||||||
| Metal binding | 122 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 195 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
Sequences
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References
| [1] | "New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis." Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M. Genes Dev. 21:601-614(2007) [PubMed: 17344419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17978 / NCDC KC 755. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000521 Genomic DNA. Translation: ABO13844.2. |
| RefSeq | YP_001086446.1. NC_009085.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A3MAA0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 4919011. |
| GenomeReviews | Gene locus A1S_3455 in contig CP000521_GR. |
| KEGG | acb:A1S_3455. |
| NMPDR | fig|400667.4.peg.3563. |
| PATRIC | 20723252. VBIAciBau103176_3485. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0129. |
| HOGENOM | HBG671001. |
| ProtClustDB | PRK12448. |
Family and domain databases | |
| HAMAP | MF_00012. IlvD. [Tree] |
| InterPro | IPR015928. Aconitase/3IPM_dehydase_swvl. IPR004404. DihydroxyA_deHydtase. IPR000581. DiOHA_6PGluconate_deHydtase. IPR020558. DiOHA_6PGluconate_deHydtase_CS. [Graphical view] |
| KO | K01687. |
| PANTHER | PTHR21000. ILVD_EDD_family. 1 hit. |
| Pfam | PF00920. ILVD_EDD. 1 hit. [Graphical view] |
| SUPFAM | SSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit. |
| TIGRFAMs | TIGR00110. IlvD. 1 hit. |
| PROSITE | PS00886. ILVD_EDD_1. 1 hit. PS00887. ILVD_EDD_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ILVD_ACIBT | ||||||||
| Accession | Primary (citable) accession number: A3MAA0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with