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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:A1S_3380
OrganismiAcinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)
Taxonomic identifieri400667 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001294591 – 404Nicotinate phosphoribosyltransferaseAdd BLAST404

Structurei

3D structure databases

ProteinModelPortaliA3MA25
SMRiA3MA25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000284928
KOiK00763
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

A3MA25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPIIHSLLD TDLYKFTMLQ VVLHKFPQTH SVYHFRCRNL EDTVYPLVDI
60 70 80 90 100
LDDLNEQLDH LCNLKYKEDE LQYLRKLRFI KSDFVDYLEL FQLKRRFIHA
110 120 130 140 150
SIDEEGRLDI RIEGPMVQAM MFEIFVLAIV NELYFSRIKT DEVWAEGERR
160 170 180 190 200
LQAKLELIQQ YEKAQQPNDP PFLVSDFGTR RRYSFEWQKH VVAAFHNTVP
210 220 230 240 250
NVFRGTSNVL LAKELNITPI GTMAHEFLQA FQALDVRLRD FQKAALETWV
260 270 280 290 300
QEYRGDLGIA LTDVVGMDAF LRDFDLYFAK LFDGLRHDSG DPYEWGDKAY
310 320 330 340 350
AHYRKLKIDT KTKMLTFSDG LNLPKAWELH QYFKDRFQVS FGIGTNLTND
360 370 380 390 400
MGQTPLNIVL KLVECNGQSV AKISDSPGKT MTDNDTFLAY LRQVFQIEEL

DEAI
Length:404
Mass (Da):47,283
Last modified:September 2, 2008 - v2
Checksum:iE1EAFAB576B7FE9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000521 Genomic DNA Translation: ABO13769.2

Genome annotation databases

EnsemblBacteriaiABO13769; ABO13769; A1S_3380
KEGGiacb:A1S_3380

Similar proteinsi

Entry informationi

Entry nameiPNCB_ACIBT
AccessioniPrimary (citable) accession number: A3MA25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health