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A3MA25

- PNCB_ACIBT

UniProt

A3MA25 - PNCB_ACIBT

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, A1S_3380
Organism
Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciABAU400667:GI0Q-3373-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:A1S_3380
OrganismiAcinetobacter baumannii (strain ATCC 17978 / NCDC KC 755)
Taxonomic identifieri400667 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000006737: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_1000129459Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi400667.A1S_3380.

Structurei

3D structure databases

ProteinModelPortaliA3MA25.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A3MA25-1 [UniParc]FASTAAdd to Basket

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MSPIIHSLLD TDLYKFTMLQ VVLHKFPQTH SVYHFRCRNL EDTVYPLVDI    50
LDDLNEQLDH LCNLKYKEDE LQYLRKLRFI KSDFVDYLEL FQLKRRFIHA 100
SIDEEGRLDI RIEGPMVQAM MFEIFVLAIV NELYFSRIKT DEVWAEGERR 150
LQAKLELIQQ YEKAQQPNDP PFLVSDFGTR RRYSFEWQKH VVAAFHNTVP 200
NVFRGTSNVL LAKELNITPI GTMAHEFLQA FQALDVRLRD FQKAALETWV 250
QEYRGDLGIA LTDVVGMDAF LRDFDLYFAK LFDGLRHDSG DPYEWGDKAY 300
AHYRKLKIDT KTKMLTFSDG LNLPKAWELH QYFKDRFQVS FGIGTNLTND 350
MGQTPLNIVL KLVECNGQSV AKISDSPGKT MTDNDTFLAY LRQVFQIEEL 400
DEAI 404
Length:404
Mass (Da):47,283
Last modified:September 2, 2008 - v2
Checksum:iE1EAFAB576B7FE9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000521 Genomic DNA. Translation: ABO13769.2.

Genome annotation databases

EnsemblBacteriaiABO13769; ABO13769; A1S_3380.
PATRICi20723104. VBIAciBau103176_3411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000521 Genomic DNA. Translation: ABO13769.2 .

3D structure databases

ProteinModelPortali A3MA25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400667.A1S_3380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO13769 ; ABO13769 ; A1S_3380 .
PATRICi 20723104. VBIAciBau103176_3411.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci ABAU400667:GI0Q-3373-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis."
    Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M.
    Genes Dev. 21:601-614(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17978 / NCDC KC 755.

Entry informationi

Entry nameiPNCB_ACIBT
AccessioniPrimary (citable) accession number: A3MA25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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