Skip Header

Contribute Send feedback
Read comments (?) or add your own

A3M9I8 (AROB_ACIBT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:A1S_3187
OrganismAcinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]
Taxonomic identifier400667 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3603603-dehydroquinate synthase HAMAP MF_00110
PRO_1000094441

Sequences

Sequence LengthMass (Da)Tools
A3M9I8 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: FDB24C4C7DA11EAD

FASTA36039,492
        10         20         30         40         50         60 
MQTLHVELGE RRYPIFIGSQ LDPKQLLEPY IHGQQVMIVS NVTVAPLYLS HYQEALESLG 

        70         80         90        100        110        120 
KTVATCILPD GEKYKDIQHL NLIFDALLEA GFNRDCTVLA LGGGVIGDMA GFASACFQRG 

       130        140        150        160        170        180 
VYFVQVPTTL LSQVDSSVGG KTGINHPLGK NMLGAFQQPQ VVLADMAQLN TLPERELSAG 

       190        200        210        220        230        240 
LAEVIKYALL GDEDFLVWLE ENMDGLVARD ADLLAEAVYR SCAHKARIVA NDEKEQGERA 

       250        260        270        280        290        300 
LLNLGHTFGH AIESYLGYGT WLHGEAVATG MVMAADLSQR LGWISNEDVA RTKKIIQRAN 

       310        320        330        340        350        360 
LPISCPQIPL DDFLGYMAHD KKVLNGQLRL VLLKQLGQAV ITKNFDVELM KQAILANQHG

« Hide

References

[1]"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis."
Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M.
Genes Dev. 21:601-614(2007) [PubMed: 17344419] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17978 / NCDC KC 755.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000521 Genomic DNA. Translation: ABO13582.2.
RefSeqYP_001086184.1. NC_009085.1.

3D structure databases

ProteinModelPortalA3M9I8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3M9I8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4919217.
GenomeReviewsGene locus A1S_3187 in contig CP000521_GR.
KEGGacb:A1S_3187.
NMPDRfig|400667.4.peg.3293.
PATRIC20722718. VBIAciBau103176_3226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_ACIBT
AccessionPrimary (citable) accession number: A3M9I8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: December 14, 2011
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents