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A3M8D6 (UPPP_ACIBT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:A1S_2768
OrganismAcinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]
Taxonomic identifier400667 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000134675

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane249 – 26921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A3M8D6 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 0062C1C3A356D3D6

FASTA27229,566
        10         20         30         40         50         60 
MENFEVIKAL FLGFVEGLTE FLPISSTGHL ILFGHIIDFH SDGGRVFEVV IQLGAILAVC 

        70         80         90        100        110        120 
WLYRQKIINL IKGFFSGDVE SRHFAISVLI AFFPAVIIGV LAVDFIKSVL FSPIVVAIAL 

       130        140        150        160        170        180 
IVGALIIFWV ESKQFEHKTD DATKITFKQA LLVGLAQCVA MIPGTSRSGA TIVGGMFAGL 

       190        200        210        220        230        240 
SRKAATEFSF FLAMPTMLGA ATFDLIKNAD VLTSDNMVNI GVGFVAAFIA ALLVVKALVL 

       250        260        270 
FVERHTLRVF AWYRIVLGVI ILIAAMFFNL SA 

« Hide

References

[1]"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis."
Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M.
Genes Dev. 21:601-614(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17978 / NCDC KC 755.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000521 Genomic DNA. Translation: ABO13180.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING400667.A1S_2768.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO13180; ABO13180; A1S_2768.
PATRIC20721848. VBIAciBau103176_2814.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycABAU400667:GI0Q-2756-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_ACIBT
AccessionPrimary (citable) accession number: A3M8D6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families