A3M8D6 (UPPP_ACIBT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	A1S_2768

Organism

Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]

Taxonomic identifier

400667 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex › Acinetobacter baumannii

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000134675
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	109 – 129	21	Helical; Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Transmembrane	186 – 206	21	Helical; Potential
	Transmembrane	222 – 242	21	Helical; Potential
	Transmembrane	249 – 269	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A3M8D6 [UniParc]. Last modified September 2, 2008. Version 2. Checksum: 0062C1C3A356D3D6	FASTA	272	29,566
	10 20 30 40 50 60 MENFEVIKAL FLGFVEGLTE FLPISSTGHL ILFGHIIDFH SDGGRVFEVV IQLGAILAVC 70 80 90 100 110 120 WLYRQKIINL IKGFFSGDVE SRHFAISVLI AFFPAVIIGV LAVDFIKSVL FSPIVVAIAL 130 140 150 160 170 180 IVGALIIFWV ESKQFEHKTD DATKITFKQA LLVGLAQCVA MIPGTSRSGA TIVGGMFAGL 190 200 210 220 230 240 SRKAATEFSF FLAMPTMLGA ATFDLIKNAD VLTSDNMVNI GVGFVAAFIA ALLVVKALVL 250 260 270 FVERHTLRVF AWYRIVLGVI ILIAAMFFNL SA

References

[1]

"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis." Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M. Genes Dev. 21:601-614(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17978 / NCDC KC 755.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000521 Genomic DNA. Translation: ABO13180.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	400667.A1S_2768.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	20721848. VBIAciBau103176_2814.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	ABAU400667:GI0Q-2771-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_ACIBT

Accession

Primary (citable) accession number: A3M8D6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 2, 2008
Last modified:	May 1, 2013
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program