A3M663 (OTC_ACIBT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	A1S_1980

Organism

Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]

Taxonomic identifier

400667 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm By similarity HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000137083
Regions
	Region	53 – 57	5	Carbamoyl phosphate binding By similarity
	Region	258 – 261	4	Ornithine binding By similarity
Sites
	Binding site	104	1	Carbamoyl phosphate By similarity
	Binding site	131	1	Carbamoyl phosphate By similarity
	Site	28	1	Important for structural integrity By similarity
	Site	144	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3M663 [UniParc]. Last modified September 2, 2008. Version 2. Checksum: C91DFB750CA7C404	FASTA	306	34,557
	10 20 30 40 50 60 MALRHFLTLR DLSTLELNRI LERASELKKM QQSNKVYQPF VGKVLGMIFE KSSTRTRISF 70 80 90 100 110 120 EAGINQFGGS AIFLSPRDTQ LGRGEPIEDS ARVISSMLDI VMIRTFGHDI VERFASYSKV 130 140 150 160 170 180 PVINGLTDDH HPCQLLADLQ TYIEHRGSIE GKTVAWIGDG NNMCNSYIEA AHMMGFKLKI 190 200 210 220 230 240 ASPKGYEPKP EFLAEFGHCV ELFDNAEDAA VNADLIVTDV WASMGQEEEQ KLREKAFADF 250 260 270 280 290 300 QVNEKLMGLA HPDCLFMHCL PAHRGEEISE TMLDHKNAVV WDEAENRLHA QKALMEFLLN ENLKKA

References

[1]

"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis." Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M. Genes Dev. 21:601-614(2007) [PubMed: 17344419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17978 / NCDC KC 755.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000521 Genomic DNA. Translation: ABO12407.2.
RefSeq	YP_001085009.2. NC_009085.1.
3D structure databases
ProteinModelPortal	A3M663.
ModBase	Search...
Protein-protein interaction databases
STRING	A3M663.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4918829.
GenomeReviews	Gene locus A1S_1980 in contig CP000521_GR.
KEGG	acb:A1S_1980.
NMPDR	fig|400667.4.peg.2070.
PATRIC	20720238. VBIAciBau103176_2026.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
ProtClustDB	PRK00779.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_ACIBT

Accession

Primary (citable) accession number: A3M663

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program