A3M5C7 (AROC_ACIBT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	A1S_1694

Organism

Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]

Taxonomic identifier

400667 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Chorismate synthase HAMAP MF_00300		PRO_0000322381

Sequences

	Sequence		Length	Mass (Da)
	A3M5C7 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 6EC0BA8A243EE418	FASTA	363	39,001
	10 20 30 40 50 60 MAGNSIGQLF RVTTCGESHG VGLMAIVDGV PPGLALTEED LQKDLDRRKP GTSKFATQRK 70 80 90 100 110 120 EPDQVEIISG VFEGKTTGTP IGLLIRNTDQ KSKDYGNIAQ TFRPGHADYT YTQKYGFRDY 130 140 150 160 170 180 RGGGRSSARE TAMRVAAGAI AKKYLAEKFG VLIRGHVTQI GNEVAEKLDW NEVPNNPFFC 190 200 210 220 230 240 GDVDAVPRFE ALVTSLREQG TSCGAKLEIL AEKVPVGWGE PVFDRLDADI AHAMMSINAV 250 260 270 280 290 300 KGVEIGDGFA VAGQFGHETR DELTSHGFLA NHAGGILGGI SSGQTIRVAI ALKPTASITT 310 320 330 340 350 360 PGKTINLNRE DTDVLTKGRH DPCVGVRATP IAEAMLAIVL MDHFLRHRAQ NADVVPPFAP IEP

References

[1]

"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis." Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M. Genes Dev. 21:601-614(2007) [PubMed: 17344419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17978 / NCDC KC 755.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000521 Genomic DNA. Translation: ABO12121.2.
RefSeq	YP_001084723.2. NC_009085.1.
3D structure databases
ProteinModelPortal	A3M5C7.
ModBase	Search...
Protein-protein interaction databases
STRING	A3M5C7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4919480.
GenomeReviews	Gene locus A1S_1694 in contig CP000521_GR.
KEGG	acb:A1S_1694.
NMPDR	fig|400667.4.peg.1777.
PATRIC	20719658. VBIAciBau103176_1736.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
ProtClustDB	PRK05382.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ACIBT

Accession

Primary (citable) accession number: A3M5C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	December 14, 2011
This is version 33 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program