Dihydroorotase - Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755)

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Reviewed, UniProtKB/Swiss-Prot A3M3K3 (PYRC_ACIBT)

Last modified September 22, 2009. Version 27. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Dihydroorotase
      Short name=DHOase
    EC=3.5.2.3

Gene names

Name:	pyrC
Ordered Locus Names:	A1S_1066

Organism

Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H₂O = N-carbamoyl-L-aspartate. HAMAP MF_00219
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the DHOase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

344

Dihydroorotase HAMAP MF_00219

PRO_1000100034

Sites

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1; via carbamate group By similarity

Metal binding

1

Zinc 2; via carbamate group By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 1 By similarity

Amino acid modifications

Modified residue

1

N6-carboxylysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

A3M3K3-1 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 88039E5E51339AC2
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344

38,724

        10         20         30         40         50         60 
MNSITLLQPD DWHAHLRDGL ALKRTVPDLA KQFARAICMP NLVPPVKTVE EALAYRERIL 

        70         80         90        100        110        120 
AHVPEGNNFD PRMVLYFTDH TSPDEVRKIK ESEHVNAIKL YPAGATTNSD NGVSDIRKVY 

       130        140        150        160        170        180 
AVIEQLEEHQ VPLLLHGEVT HNHVDIFDRE KRFLDEVLSP LLKQFPKLKV VLEHITTSDA 

       190        200        210        220        230        240 
AHFVLEQDRN VAATITPQHL LFNRNDMLVG GIKPHFYCLP ILKRQTHQTT LLEVATSGNP 

       250        260        270        280        290        300 
KFFLGTDSAP HAQNAKENAC GCAGCYSAPN AIELYAQAFD QVGKLERLEG FASHFGADFY 

       310        320        330        340 
GLPRNTSTIT LVKEDNLVPE SFDYLDNQKI IPLHAGKTLQ WRKV

References

[1]

"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis."
Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M.
Genes Dev. 21:601-614(2007) [PubMed: 17344419] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
	CP000521 Genomic DNA. Translation: ABO11497.2.
RefSeq	YP_001084099.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3M3K3.
Genome annotation databases
GeneID	4918999.
GenomeReviews	Gene locus A1S_1066 in contig CP000521_GR.
KEGG	acb:A1S_1066.
NMPDR	fig\|400667.4.peg.1093.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00219. [Tree]
InterPro	IPR006992. Amidohydro_2. IPR004721. DHOdimr. IPR002195. Dihydroorotase_CS. [Graphical view]
Pfam	PF04909. Amidohydro_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00856. pyrC_dimer. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRC_ACIBT

Accession

Primary (citable) accession number: A3M3K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 2, 2008
Last modified:	September 22, 2009
This is version 27 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents