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A3M365 (BETB_ACIBT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:A1S_0927
OrganismAcinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]
Taxonomic identifier400667 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex ›

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000133937

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

Sequences

Sequence LengthMass (Da)Tools
A3M365 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 0258A0E0B54B5F69

FASTA49053,134
        10         20         30         40         50         60 
MSDVQVHQLY IHGRYVEATS GKTFNSINPA NGEIIATLQQ ASEQDIEAAV KSAQQGQKIW 

        70         80         90        100        110        120 
AAMTAMERSR ILRRAVDILR ERNDELARLE TLDTGKAYSE TSTVDIVTGA DVLEYYAGLA 

       130        140        150        160        170        180 
TAIQGEQVPL RESSFFYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSET 

       190        200        210        220        230        240 
TPLTALKLAE IYTEAGLPDG VFNVVQGAGR EIGQWLTEHP VIEKISFTGG VETGKKVMAS 

       250        260        270        280        290        300 
AAGSTLKEVT MELGGKSPLI ICEDADLNRA ADIAVMANFF SSGQVCTNGT RVFVPKSLLV 

       310        320        330        340        350        360 
DFEKAVVERV KRIRIGDPMA EDTNFGPLTS FPHMEKVLSF IESGKQQGAK VLIGGGRATE 

       370        380        390        400        410        420 
GELAKGAYVL PTVFSDCTDQ MAIVQEEIFG PVMSILSYET EEEVIQRAND TTFGLAAGVV 

       430        440        450        460        470        480 
TQDISRAHRI IHQIEAGICW INTWGESPAE MPVGGYKQSG VGRENGLTTL GHYTRIKSIQ 

       490 
VELGDYQSIF

« Hide

References

[1]"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis."
Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M.
Genes Dev. 21:601-614(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17978 / NCDC KC 755.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000521 Genomic DNA. Translation: ABO11359.2.
RefSeqYP_001083961.2. NC_009085.1.

3D structure databases

ProteinModelPortalA3M365.
ModBaseSearch...

Protein-protein interaction databases

STRING400667.A1S_0927.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4917099.
KEGGacb:A1S_0927.
PATRIC20718051. VBIAciBau103176_0940.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycABAU400667:GI0Q-950-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_ACIBT
AccessionPrimary (citable) accession number: A3M365
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 1, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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