Reviewed, UniProtKB/Swiss-Prot A3M365 (BETB_ACIBT)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	A1S_0927

Organism

Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]

Taxonomic identifier

400667 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_1000133937
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3M365-1 [UniParc]. Last modified September 2, 2008. Version 2. Checksum: 0258A0E0B54B5F69	FASTA	490	53,134
	10 20 30 40 50 60 MSDVQVHQLY IHGRYVEATS GKTFNSINPA NGEIIATLQQ ASEQDIEAAV KSAQQGQKIW 70 80 90 100 110 120 AAMTAMERSR ILRRAVDILR ERNDELARLE TLDTGKAYSE TSTVDIVTGA DVLEYYAGLA 130 140 150 160 170 180 TAIQGEQVPL RESSFFYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSET 190 200 210 220 230 240 TPLTALKLAE IYTEAGLPDG VFNVVQGAGR EIGQWLTEHP VIEKISFTGG VETGKKVMAS 250 260 270 280 290 300 AAGSTLKEVT MELGGKSPLI ICEDADLNRA ADIAVMANFF SSGQVCTNGT RVFVPKSLLV 310 320 330 340 350 360 DFEKAVVERV KRIRIGDPMA EDTNFGPLTS FPHMEKVLSF IESGKQQGAK VLIGGGRATE 370 380 390 400 410 420 GELAKGAYVL PTVFSDCTDQ MAIVQEEIFG PVMSILSYET EEEVIQRAND TTFGLAAGVV 430 440 450 460 470 480 TQDISRAHRI IHQIEAGICW INTWGESPAE MPVGGYKQSG VGRENGLTTL GHYTRIKSIQ 490 VELGDYQSIF

References

[1]

"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis." Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M. Genes Dev. 21:601-614(2007) [PubMed: 17344419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000521 Genomic DNA. Translation: ABO11359.2.
RefSeq	YP_001083961.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3M365.
Genome annotation databases
GeneID	4917099.
GenomeReviews	Gene locus A1S_0927 in contig CP000521_GR.
KEGG	acb:A1S_0927.
NMPDR	fig|400667.4.peg.951.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
Family and domain databases
HAMAP	MF_00804. BADH. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_ACIBT

Accession

Primary (citable) accession number: A3M365

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 2, 2008
Last modified:	February 9, 2010
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)