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A3M361 (MQO_ACIBT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene names
Name:mqo
Ordered Locus Names:A1S_0923
OrganismAcinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]
Taxonomic identifier400667 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212

Cofactor

FAD By similarity. HAMAP MF_00212

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212

Sequence similarities

Belongs to the MQO family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionmalate dehydrogenase (menaquinone) activity

Inferred from electronic annotation. Source: EC

malate dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 546546Probable malate:quinone oxidoreductase HAMAP MF_00212
PRO_1000099864

Sequences

Sequence LengthMass (Da)Tools
A3M361 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 2AA186835981B9E2

FASTA54660,435
        10         20         30         40         50         60 
MKKFLKYLLV LIILILIAGI VFLFRPIASK QVQTAKDEPV VDAVLVGGGI MSATLGTYFT 

        70         80         90        100        110        120 
ELEPNWQIRM FERLDQVAQE SSNGFNNAGT GHSGFMEMNY TEEKNGKMEI AKAEKVASQF 

       130        140        150        160        170        180 
EVAKQFWSYQ VKQGVLAEPK TFINPVPHIA FVWGDNVKFL EKRYAAMIQS PLFKGMKFTE 

       190        200        210        220        230        240 
DPAVIKQWAP LVMTDRDPTQ KVAATRMEVG SDVNYGSITK QLVNHLNQNP NFKLQTSTEV 

       250        260        270        280        290        300 
TGISQNDDKT WTVSFKNLKT GKTDHVKTRF VFIGAGGAAV KLLQLTGLPE AKQYAGFPVG 

       310        320        330        340        350        360 
GEFLITDNPA ITAQHTAKVY GRAELGAPPM SVPHIDTRYI DGKKYVLFGP FATYSNKFLK 

       370        380        390        400        410        420 
NGSQLDLLAS TNKSNVLPMT TVGLENLDLV KYLVSQVMMS DEDRLNELRK YYPDAKAEDW 

       430        440        450        460        470        480 
RLSQGGQRVQ IIKKEPGKPA TLQFGTEIFA SKDGAVTALL GASPGASTSP YIMLNLLEKA 

       490        500        510        520        530        540 
FPQQTEGKWN QKLHEIVVSY KQDLSKDPVL LDKVRQYTSS TLGLNYTSPF KAANDETAAA 


PVAKAN

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References

[1]"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis."
Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M.
Genes Dev. 21:601-614(2007) [PubMed: 17344419] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17978 / NCDC KC 755.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000521 Genomic DNA. Translation: ABO11355.2.
RefSeqYP_001083957.2. NC_009085.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA3M361.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4919130.
GenomeReviewsGene locus A1S_0923 in contig CP000521_GR.
KEGGacb:A1S_0923.
NMPDRfig|400667.4.peg.947.
PATRIC20718043. VBIAciBau103176_0936.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0579.
HOGENOMHBG289663.
ProtClustDBPRK05257.

Family and domain databases

HAMAPMF_00212. MQO.
[Tree]
InterProIPR006231. Malate_quinone_OxRdtase.
[Graphical view]
KOK00116.
PANTHERPTHR13847:SF14. PTHR13847:SF14. 1 hit.
PfamPF06039. Mqo. 1 hit.
[Graphical view]
TIGRFAMsTIGR01320. Mal_quin_oxido. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMQO_ACIBT
AccessionPrimary (citable) accession number: A3M361
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: December 14, 2011
This is version 35 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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