lldD

Functionⁱ

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityⁱ

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactorⁱ

FMNUniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	24	SubstrateUniRule annotation	1
Binding siteⁱ	106	FMNUniRule annotation	1
Binding siteⁱ	127	FMNUniRule annotation	1
Binding siteⁱ	129	SubstrateUniRule annotation	1
Binding siteⁱ	155	FMNUniRule annotation	1
Binding siteⁱ	164	SubstrateUniRule annotation	1
Binding siteⁱ	251	FMNUniRule annotation	1
Active siteⁱ	275	Proton acceptorUniRule annotation	1
Binding siteⁱ	278	SubstrateUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	306 – 330	FMNUniRule annotationAdd BLAST		25

GO - Molecular functionⁱ

FMN binding Source: InterPro
lactate dehydrogenase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lactate metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	Flavoprotein, FMN

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesⁱ	Name:lldDUniRule annotation Ordered Locus Names:A1S_0069
Organismⁱ	Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)
Taxonomic identifierⁱ	400667 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex › Acinetobacter baumannii

Subcellular locationⁱ

Cell inner membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01559
; Peripheral membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01559

GO - Cellular componentⁱ

plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000383407	1 – 383	L-lactate dehydrogenaseAdd BLAST		383

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A3M0X0
SMRⁱ	A3M0X0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 380	FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST		380

Sequence similaritiesⁱ

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000217464
KEGG Orthology (KO) More...KOⁱ	K00101
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00L7

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Dⁱ	3.20.20.701 hit
HAMAPⁱ	MF_01559 L_lact_dehydr, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR012133 Alpha-hydoxy_acid_DH_FMN IPR000262 FMN-dep_DH IPR037396 FMN_HAD IPR008259 FMN_hydac_DH_AS IPR020920 LldD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01070 FMN_dh, 1 hit
PIRSFⁱ	PIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEⁱ	View protein in PROSITE PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A3M0X0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIISSGNDYR AAAQRRLPPF LFHYIDGGAY AEYTLKRNVQ DLSEIALRQR 
        60         70         80         90        100
VLNDMSALSL ETKLFNETLS MPVALAPVGL TGMYARRGEV QAAMAADKKG 
       110        120        130        140        150
IPFTLSTVSV CPIEEVAPAI NRPMWFQLYV LRDRGFMRNA LERAKAAGCS 
       160        170        180        190        200
TLVFTVDMPV PGARYRDAHS GMSGPNAAMR RYMQSVFHPH WSWNVGLMGR 
       210        220        230        240        250
PHDLGNISKY LGKPTGLEDY IGWLGSNFDP SISWKDLEWI REFWDGPMVI 
       260        270        280        290        300
KGILDPEDAK DAVRFGADGI VVSNHGGRQL DGVMSSARAL PAIADAVKGD 
       310        320        330        340        350
LAILADSGIR NGLDVVRMLA LGADTVLLGR AFVYALAAAG GQGVSNLLDL 
       360        370        380 
IDKEMRVAMT LTGAKSISDI NADCLVQAIK QGL

Length:383

Mass (Da):41,648

Last modified:September 2, 2008 - v2

Checksum:ⁱ5F274546464F785C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000521 Genomic DNA Translation: ABO10564.2

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP000521 Genomic DNA Translation: ABO10564.2

Genome annotation databases

EnsemblBacteriaⁱ	ABO10564; ABO10564; A1S_0069
KEGGⁱ	acb:A1S_0069

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A3M0X0	B7H2H0 B7IBS4 B2I061 B0V6L1 V5RDS8 D0CET8 A0A062IPQ3 N9J0C2 A0A009G8E4 A0A1C4HDW8 +17	Acinetobacter baumannii (strain AB307-0294) Acinetobacter baumannii (strain AB0057) Acinetobacter baumannii (strain ACICU) Acinetobacter baumannii (strain AYE) Acinetobacter baumannii Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81) Acinetobacter baumannii 233846 Acinetobacter baumannii NIPH 601 Acinetobacter baumannii 118362 Acinetobacter calcoaceticus And more	383	UniRef100_B7H2H0	Cluster: L-lactate dehydrogenase	28

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A3M0X0	Q6FFS1 A0A2D7VHJ1 A0A009YMK2 N9D1M5 N9S7P4 A0A2L0HWN3 A0A1Y3CVD8 A0A077L263 A0A2A5PE64 N8Y9R6 +307	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) Acinetobacter sp. Acinetobacter sp. 479375 Acinetobacter ursingii DSM 16037 = CIP 107286 Acinetobacter ursingii NIPH 706 Acinetobacter sp. ACNIH2 Acinetobacter sp. ANC 4169 Acinetobacter guillouiae (Acinetobacter genomosp. 11) Acinetobacter sp. YT-02 Acinetobacter gerneri DSM 14967 = CIP 107464 And more	384	UniRef90_Q6FFS1	Cluster: L-lactate dehydrogenase	318

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A3M0X0	B4SMK1 A0A2J0UP17 M5CZY6 A0A1D8Y5Y9 UPI00030DA2AD A0A2G7R9K8 A0A0U5I4K8 A0A239QAI8 A0A1I6JKB3 UPI00044B928A +3557	Stenotrophomonas maltophilia (strain R551-3) Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia) Stenotrophomonas maltophilia RA8 Stenotrophomonas sp. LM091 Stenotrophomonas sp. WS40 Stenotrophomonas sp. CC120222-04 Stenotrophomonas sp. RIT309 Stenotrophomonas maltophilia JV3 Stenotrophomonas sp. YR399 Stenotrophomonas acidaminiphila And more	379	UniRef50_B4SMK1	Cluster: L-lactate dehydrogenase	3,568

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000521 Genomic DNA Translation: ABO10564.2

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP000521 Genomic DNA Translation: ABO10564.2

3D structure databases

ProteinModelPortalⁱ	A3M0X0
SMRⁱ	A3M0X0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABO10564; ABO10564; A1S_0069
KEGGⁱ	acb:A1S_0069

Phylogenomic databases

HOGENOMⁱ	HOG000217464
KEGG Orthology (KO) More...KOⁱ	K00101
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00L7

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Dⁱ	3.20.20.701 hit
HAMAPⁱ	MF_01559 L_lact_dehydr, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR012133 Alpha-hydoxy_acid_DH_FMN IPR000262 FMN-dep_DH IPR037396 FMN_HAD IPR008259 FMN_hydac_DH_AS IPR020920 LldD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01070 FMN_dh, 1 hit
PIRSFⁱ	PIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEⁱ	View protein in PROSITE PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LLDD_ACIBT
Accessionⁱ	A3M0X0Primary (citable) accession number: A3M0X0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
	Last sequence update:	September 2, 2008
	Last modified:	December 20, 2017
	This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - A3M0X0 (LLDD_ACIBT)

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L-lactate dehydrogenase

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Functionⁱ

Catalytic activityⁱ

Cofactorⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A3M0X0 (LLDD_ACIBT)

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L-lactate dehydrogenase

lldD

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ