UniProtKB - A3M0X0 (LLDD_ACIBT)
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Protein
L-lactate dehydrogenase
Gene
lldD
Organism
Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)
Status
Functioni
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation
Catalytic activityi
(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation
Cofactori
FMNUniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 24 | SubstrateUniRule annotation | 1 | |
Binding sitei | 106 | FMNUniRule annotation | 1 | |
Binding sitei | 127 | FMNUniRule annotation | 1 | |
Binding sitei | 129 | SubstrateUniRule annotation | 1 | |
Binding sitei | 155 | FMNUniRule annotation | 1 | |
Binding sitei | 164 | SubstrateUniRule annotation | 1 | |
Binding sitei | 251 | FMNUniRule annotation | 1 | |
Active sitei | 275 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 278 | SubstrateUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 306 – 330 | FMNUniRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- FMN binding Source: InterPro
- lactate dehydrogenase activity Source: InterPro
GO - Biological processi
- lactate metabolic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Flavoprotein, FMN |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:lldDUniRule annotation Ordered Locus Names:A1S_0069 |
Organismi | Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) |
Taxonomic identifieri | 400667 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex › |
Subcellular locationi
- Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation
GO - Cellular componenti
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000383407 | 1 – 383 | L-lactate dehydrogenaseAdd BLAST | 383 |
Structurei
3D structure databases
ProteinModelPortali | A3M0X0 |
SMRi | A3M0X0 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 380 | FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST | 380 |
Sequence similaritiesi
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000217464 |
KOi | K00101 |
OrthoDBi | POG091H00L7 |
Family and domain databases
CDDi | cd02809 alpha_hydroxyacid_oxid_FMN, 1 hit |
Gene3Di | 3.20.20.701 hit |
HAMAPi | MF_01559 L_lact_dehydr, 1 hit |
InterProi | View protein in InterPro IPR013785 Aldolase_TIM IPR012133 Alpha-hydoxy_acid_DH_FMN IPR000262 FMN-dep_DH IPR037396 FMN_HAD IPR008259 FMN_hydac_DH_AS IPR020920 LldD |
Pfami | View protein in Pfam PF01070 FMN_dh, 1 hit |
PIRSFi | PIRSF000138 Al-hdrx_acd_dh, 1 hit |
PROSITEi | View protein in PROSITE PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A3M0X0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIISSGNDYR AAAQRRLPPF LFHYIDGGAY AEYTLKRNVQ DLSEIALRQR
60 70 80 90 100
VLNDMSALSL ETKLFNETLS MPVALAPVGL TGMYARRGEV QAAMAADKKG
110 120 130 140 150
IPFTLSTVSV CPIEEVAPAI NRPMWFQLYV LRDRGFMRNA LERAKAAGCS
160 170 180 190 200
TLVFTVDMPV PGARYRDAHS GMSGPNAAMR RYMQSVFHPH WSWNVGLMGR
210 220 230 240 250
PHDLGNISKY LGKPTGLEDY IGWLGSNFDP SISWKDLEWI REFWDGPMVI
260 270 280 290 300
KGILDPEDAK DAVRFGADGI VVSNHGGRQL DGVMSSARAL PAIADAVKGD
310 320 330 340 350
LAILADSGIR NGLDVVRMLA LGADTVLLGR AFVYALAAAG GQGVSNLLDL
360 370 380
IDKEMRVAMT LTGAKSISDI NADCLVQAIK QGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000521 Genomic DNA Translation: ABO10564.2 |
Genome annotation databases
EnsemblBacteriai | ABO10564; ABO10564; A1S_0069 |
KEGGi | acb:A1S_0069 |
Similar proteinsi
Entry informationi
Entry namei | LLDD_ACIBT | |
Accessioni | A3M0X0Primary (citable) accession number: A3M0X0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | September 2, 2008 | |
Last modified: | December 20, 2017 | |
This is version 64 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |