Reviewed, UniProtKB/Swiss-Prot A3M0W5 (G6PI_ACIBT)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	A1S_0064

Organism

Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [Complete proteome] [HAMAP]

Taxonomic identifier

400667 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000125684
Sites
	Active site	391	1	By similarity
	Active site	519	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3M0W5-1 [UniParc]. Last modified September 2, 2008. Version 2. Checksum: 7244CF6A6965DB92	FASTA	556	62,710
	10 20 30 40 50 60 MSKSIEKFPK ELVSPIAQLH SLVEKNSKLH IKELFAAEQD RFQNYSVKFD QLVFDYSKHR 70 80 90 100 110 120 ITKSVLEQLF ALAKTKQLTH WIERLFSQDK VNCTEQRAAM HWALRLPSEY SKFPELTKQV 130 140 150 160 170 180 HTQLQRMYAL VEKIHAGQYR GATGEVIQDV VNIGVGGSDL GPQMVTHALC DFKVKTAKPL 190 200 210 220 230 240 NVHFVSTMDG SQLSDLLHQL RPETTLFIIS SKSFGTIDTL SNAQTVRQWL EKALGKHDRV 250 260 270 280 290 300 VKSHFIGVST KAEKMTEWGI APENQLLLWD WVGGRYSLWS CIGFPIALTI GIDGFQQLLA 310 320 330 340 350 360 GAHAVDEHFQ NTSFEQNIPV LMALLGIWNN NFLNIQTHAV LPYDGRLKYF AAYLQQLEME 370 380 390 400 410 420 SNGKSVQRDG QKVELDTCPI VWGEVGPNAQ HAFYQLLHQG TQAVSCDFIA PIQRYNADHF 430 440 450 460 470 480 TYVENAEALI EQHHLALSNC LAQSRLLAFG NEALDSAELK NLPIYKQYEG NQPSSTLLLK 490 500 510 520 530 540 ELNPYSLGML IALYEHKVFV QSVIWNINPF DQWGVEKGKQ IADQLLPILN GAQNDLSALD 550 ASTRGLIKIL LGKVDG

References

[1]

"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis." Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M. Genes Dev. 21:601-614(2007) [PubMed: 17344419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000521 Genomic DNA. Translation: ABO10559.2.
RefSeq	YP_001083161.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3M0W5.
Genome annotation databases
GeneID	4917782.
GenomeReviews	Gene locus A1S_0064 in contig CP000521_GR.
KEGG	acb:A1S_0064.
NMPDR	fig|400667.4.peg.92.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG352954.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ACIBT

Accession

Primary (citable) accession number: A3M0W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 2, 2008
Last modified:	January 19, 2010
This is version 27 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)