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Protein

Hexokinase

Gene

HXK1

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:HXK1Imported
ORF Names:PICST_85453Imported
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258: Chromosome 8

Interactioni

Protein-protein interaction databases

STRINGi4924.PICST_85453.

Structurei

3D structure databases

ProteinModelPortaliA3M060.
SMRiA3M060. Positions 18-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000162670.
InParanoidiA3M060.
KOiK00844.
OMAiDICQSKY.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3M060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLGPKPPQ HRKGSLHDVP EALLKELEQL ESVFNVSAET LRKITDHFVL
60 70 80 90 100
ELEKGLSKKG GNIPMIPGWV LDFPTGKETG DYLAIDLGGT NLRVVLVKLG
110 120 130 140 150
GNRDFDTTQS KYPLPATMRT AKSEELWDFI AGCLKKFVED EYPEGVTEPL
160 170 180 190 200
PLGFTFSYPA SQSSINEGFL QRWTKGFDID GVEGRDVVPM LQEAIKKENV
210 220 230 240 250
PIEVVALIND TTGTLVASAY TDPETKMGLI FGTGCNGAYY DVCGEIPKLE
260 270 280 290 300
GQFHGDVAGE SLMAINCEYG AFDNELAVLP RSKFDHQIDA ESPRPGQQAF
310 320 330 340 350
EKMISGYYLG EVLRLALLDL SAKGIFFKDQ DLSKLNQPFI LDTSFPARIE
360 370 380 390 400
EDPYENLSDV QDLFQQELGI QTTDAERSVI RRLAEVIGER SARLSVCGIA
410 420 430 440 450
AICKKRGYKT AHAAADGSVF NKYPGFKERA AKGLRDIFQW ETKEDPIIIV
460 470 480
PAEDGSGVGA AVIAALTEKR LREGKSVGAK KN
Length:482
Mass (Da):52,998
Last modified:July 24, 2007 - v2
Checksum:i830C08A264BCEFDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000502 Genomic DNA. Translation: ABN68660.2.
RefSeqiXP_001386689.2. XM_001386652.1.

Genome annotation databases

GeneIDi4840806.
KEGGipic:PICST_85453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000502 Genomic DNA. Translation: ABN68660.2.
RefSeqiXP_001386689.2. XM_001386652.1.

3D structure databases

ProteinModelPortaliA3M060.
SMRiA3M060. Positions 18-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4924.PICST_85453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4840806.
KEGGipic:PICST_85453.

Phylogenomic databases

HOGENOMiHOG000162670.
InParanoidiA3M060.
KOiK00844.
OMAiDICQSKY.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545Imported.

Entry informationi

Entry nameiA3M060_PICST
AccessioniPrimary (citable) accession number: A3M060
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: July 24, 2007
Last modified: March 4, 2015
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.