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A3LYZ4

- NTE1_PICST

UniProt

A3LYZ4 - NTE1_PICST

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Protein
Lysophospholipase NTE1
Gene
NTE1, PICST_33358
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1272 – 12721 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi689 – 820132cNMP 1
Add
BLAST
Nucleotide bindingi816 – 965150cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:PICST_33358
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545Cytoplasmic By similarity
Add
BLAST
Transmembranei46 – 6621Helical; Reviewed prediction
Add
BLAST
Topological domaini67 – 8115Lumenal By similarity
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 15461444Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15461546Lysophospholipase NTE1
PRO_0000295329Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4924.PICST_33358.

Structurei

3D structure databases

ProteinModelPortaliA3LYZ4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1239 – 1403165Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1270 – 12745GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi342 – 35514His-rich
Add
BLAST
Compositional biasi495 – 646152Ser-rich
Add
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3LYZ4-1 [UniParc]FASTAAdd to Basket

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MKDSTEALNS IAFAVDTTLS SILPSSLAPP SAPPATSSFL KSIWYAFWWL     50
WSMVVFKIMN IILLYIPSKI MNALSINFEI TLNLSSILVA LSAIITVCFL 100
VVRYKYLTGY SKDTSDRKTK GKVNPSASNI NLKNQSLDYV DQKKGHRRTT 150
NYLDEFLSAI KVFGYLEKSV FHELTKNMTT QKLSHDEILY LDEKLGFSIV 200
VEGVMQVYTR ITENSNVSGG FDPDDDNELN YEKDDVLIIG NQRYQLLNEV 250
KSGAPLSSLV SVLDLLKPVD SEDSTSDMLH SFNISDDDNI SKIPEISPIS 300
LPFQGIHAGA KDDSVPPSPI IRPSKTKQLY PEIVARPKSR PHKEHTGHHL 350
HHVHHSGATI AIIPYSAFQR VQSKYPKATS HIVTMVLARL YKVTFNTIHD 400
YLGLTKEIME SEVKLNTTSS VRGANLPGYL FDGLLDKIYG ANGINEASLS 450
RKSDFQRASS VNLNKQKTTL CDAKSSRYVL LDSRLKSTHP GDLLSSVPLS 500
RRSDYYQTHS HPLSADDPLV RSAFPSSKTL SSLSSPTSNL KRASSNLKFE 550
NIRDRSFSDD REETEETSLR IAVVESIFKI LGISEKSTAM RNLSSFNSGR 600
SSVSSSIVGL SNLMSADDKF DTNAARVRFD SYNGFSSTAT SISRSSTPIK 650
FYNTINQNQL HNHHMGDSVS GINISTLSRQ HQANRNSSPT EFNFANVKSD 700
FAKCLEIKSY GPNTTIVEQG SFNSGLYYVI DGSLDVLYRP SNHGEPSSNR 750
EDNLKKLYSV KSGGVAGYLS SVVGFRSLVT IRTSKKRGVI VAHISKSDYS 800
KLMDRYYFLQ LPVATKLKKL LSPQILTIDY ALEWCHIPAG GVLCSQGDLA 850
NGFHIVLSGR FRVVRNKSDR YQGNTSDDDI LGFSDTSMDC SPSSDINNED 900
LEVLGEYGHG ESIGEVEVLT ASRRTNSLIA VRDSETARIP RTLFEMLSLS 950
NPSIMVKVSR IVASKVVYKD VLDQSSRNST LIPSSTASHI SNDYKTITIL 1000
PTVSGLPVRE FADKLVSALK AIGRNVIALD QASTLTHLGR HAFDERLAQL 1050
KLSGYFAYLE EEYETIVYIC DTPLKSNWTS TCISQGDCIL LLADAEDDVV 1100
ATGIGDYERL LINLKTMART DLCLLHPEKY VEPGSTSIWL KNRIWVQGHH 1150
HIEMEIIRKK DENSVKKRPN IISELASKIG SKTNPSIKST LEDVRLKAIS 1200
SFVKLNTSFV HSDRYKAVQP HKNDFLRLAR ILSNEAVGLV LGGGGSRGIS 1250
HVGIVTALER HGIPVDLIGG TSIGSLVGGL YAKDYNIVSI YGRAKKFSKR 1300
VASLWRSVFD LTYPVTSYIT GYEFNRGIWK IFGFTEIEDF WIRYFCNTTN 1350
ITNSTMDIHE SGYSWRFIRA SMSLAGLLPP IAFQGCMLLD GGYLDNLPVS 1400
EMKKKGAKYI IAVDVGSADD RTPMNYGDTL SGFWVLFNRW NPFSKHPNVP 1450
NMMDIQMRLA YVASVNALEA AKKTNGVIYL RPPIDNYATL DFAKFDEIYH 1500
VGLNYADKLF SSWSKNGKLP AIAGMVDKAK IKSGDDKKVL YRRNSI 1546
Length:1,546
Mass (Da):171,904
Last modified:July 24, 2007 - v2
Checksum:i844221F7DC95189F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000501 Genomic DNA. Translation: ABN68251.2.
RefSeqiXP_001386280.2. XM_001386243.1.

Genome annotation databases

GeneIDi4840528.
KEGGipic:PICST_33358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000501 Genomic DNA. Translation: ABN68251.2 .
RefSeqi XP_001386280.2. XM_001386243.1.

3D structure databases

ProteinModelPortali A3LYZ4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4924.PICST_33358.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4840528.
KEGGi pic:PICST_33358.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Entry informationi

Entry nameiNTE1_PICST
AccessioniPrimary (citable) accession number: A3LYZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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