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A3LYZ4

- NTE1_PICST

UniProt

A3LYZ4 - NTE1_PICST

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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1272 – 12721By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi689 – 820132cNMP 1Add
BLAST
Nucleotide bindingi816 – 965150cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:PICST_33358
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545CytoplasmicBy similarityAdd
BLAST
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Topological domaini67 – 8115LumenalBy similarityAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 15461444CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15461546Lysophospholipase NTE1PRO_0000295329Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4924.PICST_33358.

Structurei

3D structure databases

ProteinModelPortaliA3LYZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1239 – 1403165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1270 – 12745GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi342 – 35514His-richAdd
BLAST
Compositional biasi495 – 646152Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiA3LYZ4.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3LYZ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDSTEALNS IAFAVDTTLS SILPSSLAPP SAPPATSSFL KSIWYAFWWL
60 70 80 90 100
WSMVVFKIMN IILLYIPSKI MNALSINFEI TLNLSSILVA LSAIITVCFL
110 120 130 140 150
VVRYKYLTGY SKDTSDRKTK GKVNPSASNI NLKNQSLDYV DQKKGHRRTT
160 170 180 190 200
NYLDEFLSAI KVFGYLEKSV FHELTKNMTT QKLSHDEILY LDEKLGFSIV
210 220 230 240 250
VEGVMQVYTR ITENSNVSGG FDPDDDNELN YEKDDVLIIG NQRYQLLNEV
260 270 280 290 300
KSGAPLSSLV SVLDLLKPVD SEDSTSDMLH SFNISDDDNI SKIPEISPIS
310 320 330 340 350
LPFQGIHAGA KDDSVPPSPI IRPSKTKQLY PEIVARPKSR PHKEHTGHHL
360 370 380 390 400
HHVHHSGATI AIIPYSAFQR VQSKYPKATS HIVTMVLARL YKVTFNTIHD
410 420 430 440 450
YLGLTKEIME SEVKLNTTSS VRGANLPGYL FDGLLDKIYG ANGINEASLS
460 470 480 490 500
RKSDFQRASS VNLNKQKTTL CDAKSSRYVL LDSRLKSTHP GDLLSSVPLS
510 520 530 540 550
RRSDYYQTHS HPLSADDPLV RSAFPSSKTL SSLSSPTSNL KRASSNLKFE
560 570 580 590 600
NIRDRSFSDD REETEETSLR IAVVESIFKI LGISEKSTAM RNLSSFNSGR
610 620 630 640 650
SSVSSSIVGL SNLMSADDKF DTNAARVRFD SYNGFSSTAT SISRSSTPIK
660 670 680 690 700
FYNTINQNQL HNHHMGDSVS GINISTLSRQ HQANRNSSPT EFNFANVKSD
710 720 730 740 750
FAKCLEIKSY GPNTTIVEQG SFNSGLYYVI DGSLDVLYRP SNHGEPSSNR
760 770 780 790 800
EDNLKKLYSV KSGGVAGYLS SVVGFRSLVT IRTSKKRGVI VAHISKSDYS
810 820 830 840 850
KLMDRYYFLQ LPVATKLKKL LSPQILTIDY ALEWCHIPAG GVLCSQGDLA
860 870 880 890 900
NGFHIVLSGR FRVVRNKSDR YQGNTSDDDI LGFSDTSMDC SPSSDINNED
910 920 930 940 950
LEVLGEYGHG ESIGEVEVLT ASRRTNSLIA VRDSETARIP RTLFEMLSLS
960 970 980 990 1000
NPSIMVKVSR IVASKVVYKD VLDQSSRNST LIPSSTASHI SNDYKTITIL
1010 1020 1030 1040 1050
PTVSGLPVRE FADKLVSALK AIGRNVIALD QASTLTHLGR HAFDERLAQL
1060 1070 1080 1090 1100
KLSGYFAYLE EEYETIVYIC DTPLKSNWTS TCISQGDCIL LLADAEDDVV
1110 1120 1130 1140 1150
ATGIGDYERL LINLKTMART DLCLLHPEKY VEPGSTSIWL KNRIWVQGHH
1160 1170 1180 1190 1200
HIEMEIIRKK DENSVKKRPN IISELASKIG SKTNPSIKST LEDVRLKAIS
1210 1220 1230 1240 1250
SFVKLNTSFV HSDRYKAVQP HKNDFLRLAR ILSNEAVGLV LGGGGSRGIS
1260 1270 1280 1290 1300
HVGIVTALER HGIPVDLIGG TSIGSLVGGL YAKDYNIVSI YGRAKKFSKR
1310 1320 1330 1340 1350
VASLWRSVFD LTYPVTSYIT GYEFNRGIWK IFGFTEIEDF WIRYFCNTTN
1360 1370 1380 1390 1400
ITNSTMDIHE SGYSWRFIRA SMSLAGLLPP IAFQGCMLLD GGYLDNLPVS
1410 1420 1430 1440 1450
EMKKKGAKYI IAVDVGSADD RTPMNYGDTL SGFWVLFNRW NPFSKHPNVP
1460 1470 1480 1490 1500
NMMDIQMRLA YVASVNALEA AKKTNGVIYL RPPIDNYATL DFAKFDEIYH
1510 1520 1530 1540
VGLNYADKLF SSWSKNGKLP AIAGMVDKAK IKSGDDKKVL YRRNSI
Length:1,546
Mass (Da):171,904
Last modified:July 24, 2007 - v2
Checksum:i844221F7DC95189F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000501 Genomic DNA. Translation: ABN68251.2.
RefSeqiXP_001386280.2. XM_001386243.1.

Genome annotation databases

GeneIDi4840528.
KEGGipic:PICST_33358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000501 Genomic DNA. Translation: ABN68251.2 .
RefSeqi XP_001386280.2. XM_001386243.1.

3D structure databases

ProteinModelPortali A3LYZ4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4924.PICST_33358.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4840528.
KEGGi pic:PICST_33358.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
InParanoidi A3LYZ4.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Entry informationi

Entry nameiNTE1_PICST
AccessioniPrimary (citable) accession number: A3LYZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3