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A3LYZ4

- NTE1_PICST

UniProt

A3LYZ4 - NTE1_PICST

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1272 – 12721By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi689 – 820132cNMP 1Add
    BLAST
    Nucleotide bindingi816 – 965150cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    ORF Names:PICST_33358
    OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
    Taxonomic identifieri322104 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
    ProteomesiUP000002258: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15461546Lysophospholipase NTE1PRO_0000295329Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4924.PICST_33358.

    Structurei

    3D structure databases

    ProteinModelPortaliA3LYZ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545CytoplasmicBy similarityAdd
    BLAST
    Topological domaini67 – 8115LumenalBy similarityAdd
    BLAST
    Topological domaini103 – 15461444CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1239 – 1403165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1270 – 12745GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi342 – 35514His-richAdd
    BLAST
    Compositional biasi495 – 646152Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OMAiSPWTQTC.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 4 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 2 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3LYZ4-1 [UniParc]FASTAAdd to Basket

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    MKDSTEALNS IAFAVDTTLS SILPSSLAPP SAPPATSSFL KSIWYAFWWL     50
    WSMVVFKIMN IILLYIPSKI MNALSINFEI TLNLSSILVA LSAIITVCFL 100
    VVRYKYLTGY SKDTSDRKTK GKVNPSASNI NLKNQSLDYV DQKKGHRRTT 150
    NYLDEFLSAI KVFGYLEKSV FHELTKNMTT QKLSHDEILY LDEKLGFSIV 200
    VEGVMQVYTR ITENSNVSGG FDPDDDNELN YEKDDVLIIG NQRYQLLNEV 250
    KSGAPLSSLV SVLDLLKPVD SEDSTSDMLH SFNISDDDNI SKIPEISPIS 300
    LPFQGIHAGA KDDSVPPSPI IRPSKTKQLY PEIVARPKSR PHKEHTGHHL 350
    HHVHHSGATI AIIPYSAFQR VQSKYPKATS HIVTMVLARL YKVTFNTIHD 400
    YLGLTKEIME SEVKLNTTSS VRGANLPGYL FDGLLDKIYG ANGINEASLS 450
    RKSDFQRASS VNLNKQKTTL CDAKSSRYVL LDSRLKSTHP GDLLSSVPLS 500
    RRSDYYQTHS HPLSADDPLV RSAFPSSKTL SSLSSPTSNL KRASSNLKFE 550
    NIRDRSFSDD REETEETSLR IAVVESIFKI LGISEKSTAM RNLSSFNSGR 600
    SSVSSSIVGL SNLMSADDKF DTNAARVRFD SYNGFSSTAT SISRSSTPIK 650
    FYNTINQNQL HNHHMGDSVS GINISTLSRQ HQANRNSSPT EFNFANVKSD 700
    FAKCLEIKSY GPNTTIVEQG SFNSGLYYVI DGSLDVLYRP SNHGEPSSNR 750
    EDNLKKLYSV KSGGVAGYLS SVVGFRSLVT IRTSKKRGVI VAHISKSDYS 800
    KLMDRYYFLQ LPVATKLKKL LSPQILTIDY ALEWCHIPAG GVLCSQGDLA 850
    NGFHIVLSGR FRVVRNKSDR YQGNTSDDDI LGFSDTSMDC SPSSDINNED 900
    LEVLGEYGHG ESIGEVEVLT ASRRTNSLIA VRDSETARIP RTLFEMLSLS 950
    NPSIMVKVSR IVASKVVYKD VLDQSSRNST LIPSSTASHI SNDYKTITIL 1000
    PTVSGLPVRE FADKLVSALK AIGRNVIALD QASTLTHLGR HAFDERLAQL 1050
    KLSGYFAYLE EEYETIVYIC DTPLKSNWTS TCISQGDCIL LLADAEDDVV 1100
    ATGIGDYERL LINLKTMART DLCLLHPEKY VEPGSTSIWL KNRIWVQGHH 1150
    HIEMEIIRKK DENSVKKRPN IISELASKIG SKTNPSIKST LEDVRLKAIS 1200
    SFVKLNTSFV HSDRYKAVQP HKNDFLRLAR ILSNEAVGLV LGGGGSRGIS 1250
    HVGIVTALER HGIPVDLIGG TSIGSLVGGL YAKDYNIVSI YGRAKKFSKR 1300
    VASLWRSVFD LTYPVTSYIT GYEFNRGIWK IFGFTEIEDF WIRYFCNTTN 1350
    ITNSTMDIHE SGYSWRFIRA SMSLAGLLPP IAFQGCMLLD GGYLDNLPVS 1400
    EMKKKGAKYI IAVDVGSADD RTPMNYGDTL SGFWVLFNRW NPFSKHPNVP 1450
    NMMDIQMRLA YVASVNALEA AKKTNGVIYL RPPIDNYATL DFAKFDEIYH 1500
    VGLNYADKLF SSWSKNGKLP AIAGMVDKAK IKSGDDKKVL YRRNSI 1546
    Length:1,546
    Mass (Da):171,904
    Last modified:July 24, 2007 - v2
    Checksum:i844221F7DC95189F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000501 Genomic DNA. Translation: ABN68251.2.
    RefSeqiXP_001386280.2. XM_001386243.1.

    Genome annotation databases

    GeneIDi4840528.
    KEGGipic:PICST_33358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000501 Genomic DNA. Translation: ABN68251.2 .
    RefSeqi XP_001386280.2. XM_001386243.1.

    3D structure databases

    ProteinModelPortali A3LYZ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4924.PICST_33358.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4840528.
    KEGGi pic:PICST_33358.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OMAi SPWTQTC.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 4 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 2 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

    Entry informationi

    Entry nameiNTE1_PICST
    AccessioniPrimary (citable) accession number: A3LYZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3