A3LYE4 (3DHQ_PICST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catabolic 3-dehydroquinase
Short name=cDHQase
EC=4.2.1.10

Alternative name(s):
3-dehydroquinate dehydratase

Gene names

Name:	DQD1
ORF Names:	PICST_62322

Organism

Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) [Complete proteome]

Taxonomic identifier

322104 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Scheffersomyces › Scheffersomyces stipitis

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway By similarity. HAMAP-Rule MF_03136
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_03136
Pathway	Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2. HAMAP-Rule MF_03136
Subunit structure	Homododecamer By similarity. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another By similarity. HAMAP-Rule MF_03136
Sequence similarities	Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Quinate metabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	quinate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Catabolic 3-dehydroquinase HAMAP-Rule MF_03136		PRO_0000402375
Regions
	Region	105 – 106	2	Substrate binding By similarity
Sites
	Active site	24	1	Proton acceptor By similarity
	Active site	104	1	Proton donor By similarity
	Binding site	78	1	Substrate By similarity
	Binding site	84	1	Substrate By similarity
	Binding site	91	1	Substrate By similarity
	Binding site	115	1	Substrate By similarity
	Site	19	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3LYE4 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: B4D7A3A474A841D5	FASTA	146	16,019
	10 20 30 40 50 60 MVKKVLLING PNLNLLGTRE PEKYGTTSLK DIEQAAQNQA TAKQDGSEVL VYQNNTEGFI 70 80 90 100 110 120 IDRIHLAKQE GVGFIIINAG AYTHTSVGIR DALLGTAIPF IEVHITNVHQ REPFRHQSYL 130 140 SDKAVAVICG LGVYGYTASV EYALNY

References

[1]

"Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis." Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A., Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S., Passoth V., Richardson P.M. Nat. Biotechnol. 25:319-326(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000500 Genomic DNA. Translation: ABN67969.1.
RefSeq	XP_001385998.1. XM_001385961.1.
3D structure databases
ProteinModelPortal	A3LYE4.
SMR	A3LYE4. Positions 2-145.
ModBase	Search...
Protein-protein interaction databases
STRING	4924.PICST_62322.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4840232.
KEGG	pic:PICST_62322.
Phylogenomic databases
eggNOG	COG0757.
HOGENOM	HOG000217278.
KO	K03786.
OMA	RREPGHY.
OrthoDB	EOG4W6S5K.
Enzyme and pathway databases
UniPathway	UPA00088; UER00178.
Family and domain databases
Gene3D	3.40.50.9100. 1 hit.
HAMAP	MF_00169. AroQ.
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
PANTHER	PTHR21272. PTHR21272. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
TIGRFAMs	TIGR01088. aroQ. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

3DHQ_PICST

Accession

Primary (citable) accession number: A3LYE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 30, 2010
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program