A3LV51 (KAD1_PICST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase 1
Short name=AK 1
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase 1
Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	ADK1
ORF Names:	PICST_65737

Organism

Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) [Complete proteome]

Taxonomic identifier

322104 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Scheffersomyces

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	Adenylate kinase 1		PRO_0000365684
Regions
	Nucleotide binding	40 – 48	9	ATP By similarity
	Nucleotide binding	63 – 92	30	AMP By similarity
Sites
	Binding site	64	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3LV51 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: DD22482D812FE26A	FASTA	249	27,533
	10 20 30 40 50 60 MTVEDLKATV AKLQERIQYL EKKAGLVPDV PKSVRMVLIG PPGAGKGTQA PNLKEKFCAC 70 80 90 100 110 120 HLATGDMLRA QVAAKTALGV EAKKIMDQGG LVSDEIMVNM IKSELENNKE CANGFILDGF 130 140 150 160 170 180 PRTIPQAEKL DSMLVDRKTP LENAIELKID DELLVARITG RLVHPASGRS YHKLFNPPKK 190 200 210 220 230 240 NMIDDITGEP LVQRSDDNEA ALKKRLVTYH KQTEPIVDYY RKTGIWSGID ASQKPATVWT DILKCLGQK

References

[1]

"Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis." Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A., Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S., Passoth V., Richardson P.M. Nat. Biotechnol. 25:319-326(2007) [PubMed: 17334359] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000499 Genomic DNA. Translation: ABN66715.1.
RefSeq	XP_001384744.1. XM_001384707.1.
3D structure databases
ProteinModelPortal	A3LV51.
SMR	A3LV51. Positions 32-248.
ModBase	Search...
Protein-protein interaction databases
STRING	A3LV51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4839339.
GenomeReviews	Gene locus ADK1 in contig CP000499_GR.
KEGG	pic:PICST_65737.
Phylogenomic databases
eggNOG	fuNOG05172.
HOGENOM	HBG630208.
OMA	HEEFHPP.
OrthoDB	EOG4X0R28.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_PICST

Accession

Primary (citable) accession number: A3LV51

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program