Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A3LUT4

- PMIP_PICST

UniProt

A3LUT4 - PMIP_PICST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi595 – 5951Zinc; catalyticPROSITE-ProRule annotation
Active sitei596 – 5961PROSITE-ProRule annotation
Metal bindingi599 – 5991Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi602 – 6021Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:PICST_89481
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258: Chromosome 5

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
BLAST
Chaini30 – 812783Mitochondrial intermediate peptidasePRO_0000338593Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4924.PICST_89481.

Structurei

3D structure databases

ProteinModelPortaliA3LUT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
InParanoidiA3LUT4.
KOiK01410.
OMAiVTEMNIE.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3LUT4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLSRQLLRS TPFLTRAKPV SGKVSHFRSR TDLKGGSSNS SKSPDSVGDG
60 70 80 90 100
ASAHLRHIFD DQKYFNSFTK SAAETSGKVS SLPAIFSFRR SGLFCNDNLS
110 120 130 140 150
TPHGLIDFSK NSLREAKSLV ESMLHDVKSD PAGRLSYINK LDQLSDILCR
160 170 180 190 200
VIDVAEFIRV AHPSQKWVNA AQQTHEIMFE YMNQLNTNVE LYQNLRDILS
210 220 230 240 250
DSSVTAQLTE EEIQVGEYLK QDFERSGIHM NPSARNNFVA ITQEISLLGS
260 270 280 290 300
RFNNEIHNLK SYWCEIPRYE FEQLEDSNLK KEILGYQSKA PPSKHSSQTI
310 320 330 340 350
SIPLVGHIPF TILTTCSIES IRREIWISLH NSSDEQIATL NNFLKYRATL
360 370 380 390 400
AKMLGYKSFS HYQLEHKMAK NPENVVTFLT NLQKSLREKG VTEEIKKLYQ
410 420 430 440 450
YRDDSTISQV QKASTEDIID GVKPWDRDYL LEKLQKASNK NLEELENINE
460 470 480 490 500
YLSVGTIVAG LSELFKSIYN VEFVPVATLK GETWDQNQVR KVAVVDDSTK
510 520 530 540 550
KKLGFLYLDF WSPKVLPSHF TIVCSRKLNL DIKSETKDKM RQLVQLDEDE
560 570 580 590 600
TSQLPVISLI CNFQKSNDGH IGRFAGVENE KPTLLSLNQV DTVFHEMGHA
610 620 630 640 650
MHSMIGRTDL HNLSGTRCAT DFVELPSVLM ESFSKDPRVL CKIAKHYETG
660 670 680 690 700
EPLSPKLLAQ HQTQKVMLDE CETYMQSKMA MLDQVLHSED VVRTISEDFA
710 720 730 740 750
NFDSTPIYHS LESKLKVFAD TWSTWHGKFP HLFSYGAVYY SYLLDRAIAE
760 770 780 790 800
KIWNGLFAHD PWSREAGEKY KNSILKWGGT RDPWECLADA LENDELSKGD
810
SRAMEIIGKD SL
Length:812
Mass (Da):92,517
Last modified:July 24, 2007 - v2
Checksum:i54B0D82CDCD7BB7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000499 Genomic DNA. Translation: ABN66647.2.
RefSeqiXP_001384676.2. XM_001384639.1.

Genome annotation databases

GeneIDi4839065.
KEGGipic:PICST_89481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000499 Genomic DNA. Translation: ABN66647.2 .
RefSeqi XP_001384676.2. XM_001384639.1.

3D structure databases

ProteinModelPortali A3LUT4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4924.PICST_89481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4839065.
KEGGi pic:PICST_89481.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
InParanoidi A3LUT4.
KOi K01410.
OMAi VTEMNIE.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Entry informationi

Entry nameiPMIP_PICST
AccessioniPrimary (citable) accession number: A3LUT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3