Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A3LUT4

- PMIP_PICST

UniProt

A3LUT4 - PMIP_PICST

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi595 – 5951Zinc; catalyticPROSITE-ProRule annotation
    Active sitei596 – 5961PROSITE-ProRule annotation
    Metal bindingi599 – 5991Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi602 – 6021Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:PICST_89481
    OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
    Taxonomic identifieri322104 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
    ProteomesiUP000002258: Chromosome 5

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
    BLAST
    Chaini30 – 812783Mitochondrial intermediate peptidasePRO_0000338593Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4924.PICST_89481.

    Structurei

    3D structure databases

    ProteinModelPortaliA3LUT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    HOGENOMiHOG000076521.
    KOiK01410.
    OMAiVTEMNIE.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A3LUT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSRQLLRS TPFLTRAKPV SGKVSHFRSR TDLKGGSSNS SKSPDSVGDG    50
    ASAHLRHIFD DQKYFNSFTK SAAETSGKVS SLPAIFSFRR SGLFCNDNLS 100
    TPHGLIDFSK NSLREAKSLV ESMLHDVKSD PAGRLSYINK LDQLSDILCR 150
    VIDVAEFIRV AHPSQKWVNA AQQTHEIMFE YMNQLNTNVE LYQNLRDILS 200
    DSSVTAQLTE EEIQVGEYLK QDFERSGIHM NPSARNNFVA ITQEISLLGS 250
    RFNNEIHNLK SYWCEIPRYE FEQLEDSNLK KEILGYQSKA PPSKHSSQTI 300
    SIPLVGHIPF TILTTCSIES IRREIWISLH NSSDEQIATL NNFLKYRATL 350
    AKMLGYKSFS HYQLEHKMAK NPENVVTFLT NLQKSLREKG VTEEIKKLYQ 400
    YRDDSTISQV QKASTEDIID GVKPWDRDYL LEKLQKASNK NLEELENINE 450
    YLSVGTIVAG LSELFKSIYN VEFVPVATLK GETWDQNQVR KVAVVDDSTK 500
    KKLGFLYLDF WSPKVLPSHF TIVCSRKLNL DIKSETKDKM RQLVQLDEDE 550
    TSQLPVISLI CNFQKSNDGH IGRFAGVENE KPTLLSLNQV DTVFHEMGHA 600
    MHSMIGRTDL HNLSGTRCAT DFVELPSVLM ESFSKDPRVL CKIAKHYETG 650
    EPLSPKLLAQ HQTQKVMLDE CETYMQSKMA MLDQVLHSED VVRTISEDFA 700
    NFDSTPIYHS LESKLKVFAD TWSTWHGKFP HLFSYGAVYY SYLLDRAIAE 750
    KIWNGLFAHD PWSREAGEKY KNSILKWGGT RDPWECLADA LENDELSKGD 800
    SRAMEIIGKD SL 812
    Length:812
    Mass (Da):92,517
    Last modified:July 24, 2007 - v2
    Checksum:i54B0D82CDCD7BB7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000499 Genomic DNA. Translation: ABN66647.2.
    RefSeqiXP_001384676.2. XM_001384639.1.

    Genome annotation databases

    GeneIDi4839065.
    KEGGipic:PICST_89481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000499 Genomic DNA. Translation: ABN66647.2 .
    RefSeqi XP_001384676.2. XM_001384639.1.

    3D structure databases

    ProteinModelPortali A3LUT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4924.PICST_89481.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4839065.
    KEGGi pic:PICST_89481.

    Phylogenomic databases

    eggNOGi COG0339.
    HOGENOMi HOG000076521.
    KOi K01410.
    OMAi VTEMNIE.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

    Entry informationi

    Entry nameiPMIP_PICST
    AccessioniPrimary (citable) accession number: A3LUT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3