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A3LUT4

- PMIP_PICST

UniProt

A3LUT4 - PMIP_PICST

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Protein
Mitochondrial intermediate peptidase
Gene
OCT1, PICST_89481
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi595 – 5951Zinc; catalytic By similarity
Active sitei596 – 5961 By similarity
Metal bindingi599 – 5991Zinc; catalytic By similarity
Metal bindingi602 – 6021Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:PICST_89481
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258: Chromosome 5

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929Mitochondrion Reviewed prediction
Add
BLAST
Chaini30 – 812783Mitochondrial intermediate peptidase
PRO_0000338593Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4924.PICST_89481.

Structurei

3D structure databases

ProteinModelPortaliA3LUT4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
KOiK01410.
OMAiVTEMNIE.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3LUT4-1 [UniParc]FASTAAdd to Basket

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MRLSRQLLRS TPFLTRAKPV SGKVSHFRSR TDLKGGSSNS SKSPDSVGDG    50
ASAHLRHIFD DQKYFNSFTK SAAETSGKVS SLPAIFSFRR SGLFCNDNLS 100
TPHGLIDFSK NSLREAKSLV ESMLHDVKSD PAGRLSYINK LDQLSDILCR 150
VIDVAEFIRV AHPSQKWVNA AQQTHEIMFE YMNQLNTNVE LYQNLRDILS 200
DSSVTAQLTE EEIQVGEYLK QDFERSGIHM NPSARNNFVA ITQEISLLGS 250
RFNNEIHNLK SYWCEIPRYE FEQLEDSNLK KEILGYQSKA PPSKHSSQTI 300
SIPLVGHIPF TILTTCSIES IRREIWISLH NSSDEQIATL NNFLKYRATL 350
AKMLGYKSFS HYQLEHKMAK NPENVVTFLT NLQKSLREKG VTEEIKKLYQ 400
YRDDSTISQV QKASTEDIID GVKPWDRDYL LEKLQKASNK NLEELENINE 450
YLSVGTIVAG LSELFKSIYN VEFVPVATLK GETWDQNQVR KVAVVDDSTK 500
KKLGFLYLDF WSPKVLPSHF TIVCSRKLNL DIKSETKDKM RQLVQLDEDE 550
TSQLPVISLI CNFQKSNDGH IGRFAGVENE KPTLLSLNQV DTVFHEMGHA 600
MHSMIGRTDL HNLSGTRCAT DFVELPSVLM ESFSKDPRVL CKIAKHYETG 650
EPLSPKLLAQ HQTQKVMLDE CETYMQSKMA MLDQVLHSED VVRTISEDFA 700
NFDSTPIYHS LESKLKVFAD TWSTWHGKFP HLFSYGAVYY SYLLDRAIAE 750
KIWNGLFAHD PWSREAGEKY KNSILKWGGT RDPWECLADA LENDELSKGD 800
SRAMEIIGKD SL 812
Length:812
Mass (Da):92,517
Last modified:July 24, 2007 - v2
Checksum:i54B0D82CDCD7BB7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000499 Genomic DNA. Translation: ABN66647.2.
RefSeqiXP_001384676.2. XM_001384639.1.

Genome annotation databases

GeneIDi4839065.
KEGGipic:PICST_89481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000499 Genomic DNA. Translation: ABN66647.2 .
RefSeqi XP_001384676.2. XM_001384639.1.

3D structure databases

ProteinModelPortali A3LUT4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4924.PICST_89481.

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4839065.
KEGGi pic:PICST_89481.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
KOi K01410.
OMAi VTEMNIE.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Entry informationi

Entry nameiPMIP_PICST
AccessioniPrimary (citable) accession number: A3LUT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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