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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59ATPPROSITE-ProRule annotation1
Active sitei174Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 41ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
ORF Names:PICST_89025
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
Proteomesi
  • UP000002258 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129501 – 431Serine/threonine-protein kinase SSN3Add BLAST431

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi322104.XP_001384590.2.

Structurei

3D structure databases

ProteinModelPortaliA3LUB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 355Protein kinasePROSITE-ProRule annotationAdd BLAST329

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi407 – 424Asn-richAdd BLAST18

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0666. Eukaryota.
ENOG410XPPA. LUCA.
HOGENOMiHOG000233024.
InParanoidiA3LUB9.
KOiK02208.
OMAiVSQDDND.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3LUB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNSILTLG PFKHRKDLTR ESVLSTYQII GYIAAGTYGK VYKAKLKNTA
60 70 80 90 100
SAEQLFAIKK FKSDNHSSNR SHHNHDINGN EIVHYTGISQ SAIREMSLCR
110 120 130 140 150
ELNNKNITKL VDIILENKSI YMIFEFCEHD LLQIIHYHSH PEVKPIPQAT
160 170 180 190 200
VKSLIWQILN GVTFLHQNWI FHRDLKPANI MVSSSGVVKI GDLGLARKFN
210 220 230 240 250
NPLQSLYTGD KVVVTIWYRA PELLLGARHY TPAIDLWAVG CILAELLSLR
260 270 280 290 300
PIFKGEEAKI DINNKKSVPF QKNQFQKIVE VLGTPSMKNW PALNKYPEFI
310 320 330 340 350
SFQQQLTTNY PPNLVNWYKM IGSSNKQCLE LLKGLLEYDP LVRLTADNAL
360 370 380 390 400
VHPYFLELPK VQENAFEGLN LKYPKRRIYT DDNDIISNQA INQNFKRHGG
410 420 430
AYDDQHNNSN NNTNNSLNAN NANNVPRKRA R
Length:431
Mass (Da):49,251
Last modified:July 24, 2007 - v2
Checksum:i2A3FA1E2D2D696CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000498 Genomic DNA. Translation: ABN66561.2.
RefSeqiXP_001384590.2. XM_001384553.1.

Genome annotation databases

EnsemblFungiiABN66561; ABN66561; PICST_89025.
GeneIDi4838657.
KEGGipic:PICST_89025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000498 Genomic DNA. Translation: ABN66561.2.
RefSeqiXP_001384590.2. XM_001384553.1.

3D structure databases

ProteinModelPortaliA3LUB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322104.XP_001384590.2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiABN66561; ABN66561; PICST_89025.
GeneIDi4838657.
KEGGipic:PICST_89025.

Phylogenomic databases

eggNOGiKOG0666. Eukaryota.
ENOG410XPPA. LUCA.
HOGENOMiHOG000233024.
InParanoidiA3LUB9.
KOiK02208.
OMAiVSQDDND.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSN3_PICST
AccessioniPrimary (citable) accession number: A3LUB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.