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A3LR11 (A3LR11_PICST) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding77 – 793NADP By similarity
Nucleotide binding311 – 3166NADP By similarity
Region96 – 1027Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2531Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2761Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site791Substrate By similarity PIRSR PIRSR000108-2
Binding site841NADP By similarity
Binding site1111Substrate By similarity PIRSR PIRSR000108-2
Binding site1341Substrate By similarity PIRSR PIRSR000108-2
Binding site2611NADP By similarity
Binding site3291NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1411Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2131Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A3LR11 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 1CEE1D70594A6B86

FASTA41046,099
        10         20         30         40         50         60 
MAISKITVKN PIVEMDGDEQ TRIIWQFIKD KLILPYLNID LKYYDLGIEY RDQTDDKVTT 

        70         80         90        100        110        120 
DAAKAILEYG VGVKCATITP DEARVKEFNL KKMWLSPNGT LRNILGGTVF REPIVIDNIP 

       130        140        150        160        170        180 
RIVPQWEKPI IIGRHAFGDQ YKATDIIVPQ AGEVSLIFKP ADGSPAQEYP VYNFQGAGVA 

       190        200        210        220        230        240 
LAMYNTDESI TDFAESSFRL ALERKLNLFS STKNTILKKY DGRFKDIFEG LYASKYQKLF 

       250        260        270        280        290        300 
EAEGIWYEHR LIDDMVAQML KSKGGYIIAM KNYDGDVQSD IVAQGFGSLG LMTSVLMTPD 

       310        320        330        340        350        360 
GKAFEAEAAH GTVTRHYRQH QQGKETSTNS IASIFAWTRG LIQRGKLDKT PEVSEFAEKL 

       370        380        390        400        410 
EQATIETVSK DNIMTKDLSL AQGKTERSSY VTTEEFIDAV AARLNKNLGY 

« Hide

References

[1]"Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis."
Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A., Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S., Passoth V., Richardson P.M.
Nat. Biotechnol. 25:319-326(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000497 Genomic DNA. Translation: ABN65656.1.
RefSeqXP_001383685.1. XM_001383648.1.

3D structure databases

ProteinModelPortalA3LR11.
SMRA3LR11. Positions 2-409.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4924.PICST_43870.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4838320.
KEGGpic:PICST_43870.

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAANTIRRN.
OrthoDBEOG7G4QQD.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA3LR11_PICST
AccessionPrimary (citable) accession number: A3LR11
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 13, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)