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Protein

Isocitrate dehydrogenase [NADP]

Gene

IDP2

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791SubstrateUniRule annotation
Binding sitei84 – 841NADPUniRule annotation
Binding sitei111 – 1111SubstrateUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Sitei141 – 1411Critical for catalysisUniRule annotation
Sitei213 – 2131Critical for catalysisUniRule annotation
Metal bindingi253 – 2531Magnesium or manganeseUniRule annotation
Binding sitei261 – 2611NADPUniRule annotation
Metal bindingi276 – 2761Magnesium or manganeseUniRule annotation
Binding sitei329 – 3291NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 793NADPUniRule annotation
Nucleotide bindingi311 – 3166NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:IDP2Imported
ORF Names:PICST_43870Imported
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258 Componenti: Chromosome 3

Interactioni

Protein-protein interaction databases

STRINGi322104.XP_001383685.1.

Structurei

3D structure databases

ProteinModelPortaliA3LR11.
SMRiA3LR11. Positions 2-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 1027Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
InParanoidiA3LR11.
KOiK00031.
OMAiPQWEKPI.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3LR11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISKITVKN PIVEMDGDEQ TRIIWQFIKD KLILPYLNID LKYYDLGIEY
60 70 80 90 100
RDQTDDKVTT DAAKAILEYG VGVKCATITP DEARVKEFNL KKMWLSPNGT
110 120 130 140 150
LRNILGGTVF REPIVIDNIP RIVPQWEKPI IIGRHAFGDQ YKATDIIVPQ
160 170 180 190 200
AGEVSLIFKP ADGSPAQEYP VYNFQGAGVA LAMYNTDESI TDFAESSFRL
210 220 230 240 250
ALERKLNLFS STKNTILKKY DGRFKDIFEG LYASKYQKLF EAEGIWYEHR
260 270 280 290 300
LIDDMVAQML KSKGGYIIAM KNYDGDVQSD IVAQGFGSLG LMTSVLMTPD
310 320 330 340 350
GKAFEAEAAH GTVTRHYRQH QQGKETSTNS IASIFAWTRG LIQRGKLDKT
360 370 380 390 400
PEVSEFAEKL EQATIETVSK DNIMTKDLSL AQGKTERSSY VTTEEFIDAV
410
AARLNKNLGY
Length:410
Mass (Da):46,099
Last modified:April 3, 2007 - v1
Checksum:i1CEE1D70594A6B86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000497 Genomic DNA. Translation: ABN65656.1.
RefSeqiXP_001383685.1. XM_001383648.1.

Genome annotation databases

GeneIDi4838320.
KEGGipic:PICST_43870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000497 Genomic DNA. Translation: ABN65656.1.
RefSeqiXP_001383685.1. XM_001383648.1.

3D structure databases

ProteinModelPortaliA3LR11.
SMRiA3LR11. Positions 2-409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322104.XP_001383685.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4838320.
KEGGipic:PICST_43870.

Phylogenomic databases

HOGENOMiHOG000019858.
InParanoidiA3LR11.
KOiK00031.
OMAiPQWEKPI.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545Imported.

Entry informationi

Entry nameiA3LR11_PICST
AccessioniPrimary (citable) accession number: A3LR11
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 24, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.