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A3LR11

- A3LR11_PICST

UniProt

A3LR11 - A3LR11_PICST

Protein

Isocitrate dehydrogenase [NADP]

Gene

IDP2

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791SubstrateUniRule annotation
    Binding sitei84 – 841NADPUniRule annotation
    Binding sitei111 – 1111SubstrateUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Sitei141 – 1411Critical for catalysisUniRule annotation
    Sitei213 – 2131Critical for catalysisUniRule annotation
    Metal bindingi253 – 2531Magnesium or manganese
    Binding sitei261 – 2611NADPUniRule annotation
    Metal bindingi276 – 2761Magnesium or manganese
    Binding sitei329 – 3291NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi77 – 793NADPUniRule annotation
    Nucleotide bindingi311 – 3166NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:IDP2Imported
    ORF Names:PICST_43870Imported
    OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
    Taxonomic identifieri322104 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
    ProteomesiUP000002258: Chromosome 3

    Interactioni

    Protein-protein interaction databases

    STRINGi4924.PICST_43870.

    Structurei

    3D structure databases

    ProteinModelPortaliA3LR11.
    SMRiA3LR11. Positions 2-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni96 – 1027Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiQTRIIWQ.
    OrthoDBiEOG7G4QQD.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3LR11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAISKITVKN PIVEMDGDEQ TRIIWQFIKD KLILPYLNID LKYYDLGIEY    50
    RDQTDDKVTT DAAKAILEYG VGVKCATITP DEARVKEFNL KKMWLSPNGT 100
    LRNILGGTVF REPIVIDNIP RIVPQWEKPI IIGRHAFGDQ YKATDIIVPQ 150
    AGEVSLIFKP ADGSPAQEYP VYNFQGAGVA LAMYNTDESI TDFAESSFRL 200
    ALERKLNLFS STKNTILKKY DGRFKDIFEG LYASKYQKLF EAEGIWYEHR 250
    LIDDMVAQML KSKGGYIIAM KNYDGDVQSD IVAQGFGSLG LMTSVLMTPD 300
    GKAFEAEAAH GTVTRHYRQH QQGKETSTNS IASIFAWTRG LIQRGKLDKT 350
    PEVSEFAEKL EQATIETVSK DNIMTKDLSL AQGKTERSSY VTTEEFIDAV 400
    AARLNKNLGY 410
    Length:410
    Mass (Da):46,099
    Last modified:April 3, 2007 - v1
    Checksum:i1CEE1D70594A6B86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000497 Genomic DNA. Translation: ABN65656.1.
    RefSeqiXP_001383685.1. XM_001383648.1.

    Genome annotation databases

    GeneIDi4838320.
    KEGGipic:PICST_43870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000497 Genomic DNA. Translation: ABN65656.1 .
    RefSeqi XP_001383685.1. XM_001383648.1.

    3D structure databases

    ProteinModelPortali A3LR11.
    SMRi A3LR11. Positions 2-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4924.PICST_43870.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4838320.
    KEGGi pic:PICST_43870.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi QTRIIWQ.
    OrthoDBi EOG7G4QQD.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545Imported.

    Entry informationi

    Entry nameiA3LR11_PICST
    AccessioniPrimary (citable) accession number: A3LR11
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3