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A3LR11

- A3LR11_PICST

UniProt

A3LR11 - A3LR11_PICST

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Protein

Isocitrate dehydrogenase [NADP]

Gene

IDP2

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791SubstrateUniRule annotation
Binding sitei84 – 841NADPUniRule annotation
Binding sitei111 – 1111SubstrateUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Sitei141 – 1411Critical for catalysisUniRule annotation
Sitei213 – 2131Critical for catalysisUniRule annotation
Metal bindingi253 – 2531Magnesium or manganese
Binding sitei261 – 2611NADPUniRule annotation
Metal bindingi276 – 2761Magnesium or manganese
Binding sitei329 – 3291NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 793NADPUniRule annotation
Nucleotide bindingi311 – 3166NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:IDP2Imported
ORF Names:PICST_43870Imported
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258: Chromosome 3

Interactioni

Protein-protein interaction databases

STRINGi4924.PICST_43870.

Structurei

3D structure databases

ProteinModelPortaliA3LR11.
SMRiA3LR11. Positions 2-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 1027Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
InParanoidiA3LR11.
KOiK00031.
OMAiQTRIIWQ.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3LR11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAISKITVKN PIVEMDGDEQ TRIIWQFIKD KLILPYLNID LKYYDLGIEY
60 70 80 90 100
RDQTDDKVTT DAAKAILEYG VGVKCATITP DEARVKEFNL KKMWLSPNGT
110 120 130 140 150
LRNILGGTVF REPIVIDNIP RIVPQWEKPI IIGRHAFGDQ YKATDIIVPQ
160 170 180 190 200
AGEVSLIFKP ADGSPAQEYP VYNFQGAGVA LAMYNTDESI TDFAESSFRL
210 220 230 240 250
ALERKLNLFS STKNTILKKY DGRFKDIFEG LYASKYQKLF EAEGIWYEHR
260 270 280 290 300
LIDDMVAQML KSKGGYIIAM KNYDGDVQSD IVAQGFGSLG LMTSVLMTPD
310 320 330 340 350
GKAFEAEAAH GTVTRHYRQH QQGKETSTNS IASIFAWTRG LIQRGKLDKT
360 370 380 390 400
PEVSEFAEKL EQATIETVSK DNIMTKDLSL AQGKTERSSY VTTEEFIDAV
410
AARLNKNLGY
Length:410
Mass (Da):46,099
Last modified:April 3, 2007 - v1
Checksum:i1CEE1D70594A6B86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000497 Genomic DNA. Translation: ABN65656.1.
RefSeqiXP_001383685.1. XM_001383648.1.

Genome annotation databases

GeneIDi4838320.
KEGGipic:PICST_43870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000497 Genomic DNA. Translation: ABN65656.1 .
RefSeqi XP_001383685.1. XM_001383648.1.

3D structure databases

ProteinModelPortali A3LR11.
SMRi A3LR11. Positions 2-409.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4924.PICST_43870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4838320.
KEGGi pic:PICST_43870.

Phylogenomic databases

HOGENOMi HOG000019858.
InParanoidi A3LR11.
KOi K00031.
OMAi QTRIIWQ.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545Imported.

Entry informationi

Entry nameiA3LR11_PICST
AccessioniPrimary (citable) accession number: A3LR11
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3