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A3LR11

- A3LR11_PICST

UniProt

A3LR11 - A3LR11_PICST

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Protein
Isocitrate dehydrogenase [NADP]
Gene
IDP2, PICST_43870
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Substrate By similarityUniRule annotation
Binding sitei84 – 841NADP By similarityUniRule annotation
Binding sitei111 – 1111Substrate By similarityUniRule annotation
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Sitei141 – 1411Critical for catalysis By similarity
Sitei213 – 2131Critical for catalysis By similarityUniRule annotation
Metal bindingi253 – 2531Magnesium or manganese By similarityUniRule annotation
Binding sitei261 – 2611NADP By similarityUniRule annotation
Metal bindingi276 – 2761Magnesium or manganese By similarityUniRule annotation
Binding sitei329 – 3291NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 793NADP By similarityUniRule annotation
Nucleotide bindingi311 – 3166NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:IDP2Imported
ORF Names:PICST_43870Imported
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258: Chromosome 3

Interactioni

Protein-protein interaction databases

STRINGi4924.PICST_43870.

Structurei

3D structure databases

ProteinModelPortaliA3LR11.
SMRiA3LR11. Positions 2-409.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 1027Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiQTRIIWQ.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3LR11-1 [UniParc]FASTAAdd to Basket

« Hide

MAISKITVKN PIVEMDGDEQ TRIIWQFIKD KLILPYLNID LKYYDLGIEY    50
RDQTDDKVTT DAAKAILEYG VGVKCATITP DEARVKEFNL KKMWLSPNGT 100
LRNILGGTVF REPIVIDNIP RIVPQWEKPI IIGRHAFGDQ YKATDIIVPQ 150
AGEVSLIFKP ADGSPAQEYP VYNFQGAGVA LAMYNTDESI TDFAESSFRL 200
ALERKLNLFS STKNTILKKY DGRFKDIFEG LYASKYQKLF EAEGIWYEHR 250
LIDDMVAQML KSKGGYIIAM KNYDGDVQSD IVAQGFGSLG LMTSVLMTPD 300
GKAFEAEAAH GTVTRHYRQH QQGKETSTNS IASIFAWTRG LIQRGKLDKT 350
PEVSEFAEKL EQATIETVSK DNIMTKDLSL AQGKTERSSY VTTEEFIDAV 400
AARLNKNLGY 410
Length:410
Mass (Da):46,099
Last modified:April 3, 2007 - v1
Checksum:i1CEE1D70594A6B86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000497 Genomic DNA. Translation: ABN65656.1.
RefSeqiXP_001383685.1. XM_001383648.1.

Genome annotation databases

GeneIDi4838320.
KEGGipic:PICST_43870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000497 Genomic DNA. Translation: ABN65656.1 .
RefSeqi XP_001383685.1. XM_001383648.1.

3D structure databases

ProteinModelPortali A3LR11.
SMRi A3LR11. Positions 2-409.
ModBasei Search...

Protein-protein interaction databases

STRINGi 4924.PICST_43870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4838320.
KEGGi pic:PICST_43870.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi QTRIIWQ.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Entry informationi

Entry nameiA3LR11_PICST
AccessioniPrimary (citable) accession number: A3LR11
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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