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A3LQ22

- A3LQ22_PICST

UniProt

A3LQ22 - A3LQ22_PICST

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene
PICST_41120
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Enzyme regulationi

Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3 By similarity.UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
ORF Names:PICST_41120Imported
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258: Chromosome 2

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi4924.PICST_41120.

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

KOiK11427.
OMAiDVLIINN.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A3LQ22-1 [UniParc]FASTAAdd to Basket

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VKTLTASNVW TQDEIEHFHT CIVHNATRTG MGHLIEQKSI AELNNAVTQL     50
MSRFYWTKGE MTFLENHLGA GVAELCHEIP LRAKHGIVQM KSVRDLEVTI 100
AEKKVVNLTD SSMEDTTEDD NLAYCIQHDL SRETLEALFP DWSLSETLDR 150
IVFQAGPLDS IALTTGEKQI IKDSIKKQKS LESVQFNFPC RSKDYLVEKF 200
KEFEFVSSRK TKFKSLSERL LYEAKWVLYS SGETFTTTRR SRKRALEESF 250
ETMEKEALVS IYTKPAPKQE MTPEELEERE RRREALKESR RLANERKALL 300
RKQRKEDLER RKAAGLIKAK PKSDITHSIK DLLAGSEHFQ SVIGDKKKVE 350
EGQKRKRIQA VHYRPEIEPK KPSKLKVRHR QAEKSKIKLA LKLKKQQEHN 400
KRKPKKEPKK KKKTVEEESL ATPETEEFIK EEIDEDEEEE EEEDTYSPFD 450
PVDLNSDSFV PLHGRQFYAE EIYVDKPHVP ELKFVEVTEE SENSLISSST 500
LTETKRIMTT NDDDIVYEDC LAADIIRSHI KNYRDLPISF PPLLDPSSSE 550
RKIYPTNKVR IRFLLYPQHC ESFILAAPKT NELDPVYEII KLFMIHYALF 600
FSHSSEIRRI ITEEYCQKIE HSIEENDFSD FMFVVDKWNA LMLKLSPNEE 650
AVQSIVQSGK EDINAGLRSY LSEQEIRVPT SEDLKLQAFL EAVILEDLSP 700
TFQLIKEEPS DAEKQEFVPK HLGDVEAPKN VSDELKDMKP DDYNLIFFTR 750
LKEKTEISRF ATQQILLRIY SRIVSTDSRK LRSYKAFTAE VYGELLPSFT 800
SEVLEKVNLL PNQKFYDLGS GVGNTTFQAA LEFGASMSGG CELMEHASKL 850
TKLQEGLLQK HMAVLGLKKL NFNFALSQSF VDNDPVRDAA SDCEVLIINN 900
YLFDGNLNAE VGRLLCGLKP GTKIISLRNF ISPRYRATGD TIFDFFKVEK 950
HEMSDFLSVS WTANKVPYYI STVQDRILPE YLGKDESPDS DRSTPTLKSE 1000
NGSSENLAGS LTPFTATPEP DMFKDLSCVL GDEDDILLH 1039
Length:1,039
Mass (Da):119,382
Last modified:July 24, 2007 - v2
Checksum:i37D9E081E7B24A97
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000496 Genomic DNA. Translation: ABN64600.2.
RefSeqiXP_001382629.2. XM_001382592.1.

Genome annotation databases

GeneIDi4837176.
KEGGipic:PICST_41120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000496 Genomic DNA. Translation: ABN64600.2 .
RefSeqi XP_001382629.2. XM_001382592.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4924.PICST_41120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4837176.
KEGGi pic:PICST_41120.

Phylogenomic databases

KOi K11427.
OMAi DVLIINN.
OrthoDBi EOG7KH9VN.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Entry informationi

Entry nameiA3LQ22_PICST
AccessioniPrimary (citable) accession number: A3LQ22
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi