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Protein

DNA ligase

Gene

PICST_56005

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:PICST_56005Imported
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258 Componenti: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi322104.XP_001382465.2.

Structurei

3D structure databases

ProteinModelPortaliA3LP53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiA3LP53.
KOiK10747.
OMAiKSASTHN.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3LP53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRQQSIGR FFGSAMSVDS LLSQTVNKSP KNQKSESLTD EQNKREAFQV
60 70 80 90 100
SQQESEKDQE QKPDTDPSES EPEKDKTEEI KEASELIKLS EKEHEKHVGE
110 120 130 140 150
KLSAKIPYSK LTDVLDKIEA ESSRLKITAI VSEFFLEILK QSTVDKLVKI
160 170 180 190 200
VYLFINRLGP DYEPDLELGL GETILIKAIS ECYGRPSTKI KKDYQEVGDL
210 220 230 240 250
GLVAQKSRSG QPTMFKPAPL DVDQVFENLT KIAKSTGKDS QAKKISLINK
260 270 280 290 300
MLTACNAKSS EAKFLIRSLE GKLRIGLAEK TVLIGLAQAF VNYEAKDSKR
310 320 330 340 350
INPEKLTQSE DVVREAFSQI PNYEILIRNA YEYGIFNLLD HCQLTPGIPL
360 370 380 390 400
KPMLAKPTKS ISEVLDRFQG EEFTCEYKYD GERAQVHLLH DGTVRIYSRN
410 420 430 440 450
SEDMSERYPD LISIMKDFIK TQEGQAPSMI LDCEAVAWDR VANKILPFQV
460 470 480 490 500
LSTRKRKDVD EKDITVHICL FAFDILYFDN EPLITKSLKE RRQVMEENLT
510 520 530 540 550
PMDGKFQFAT AKNSSNLDEL QQFLDQSVKD SCEGLMVKML NGKESYYEPS
560 570 580 590 600
KRSRNWLKLK KDYLAGVGDS LDLVVIGAYI GRGKRTGNYG GFLLASYNQD
610 620 630 640 650
TGEYETTCKI GTGFSDEDLA SLHTKLKPTE ISVPKPYYVY DTTNSNAKPD
660 670 680 690 700
VWFEPTTIFE VLTADLSLSP IYKAAHQEYG KGISLRFPRF LRIRDDKGIE
710
DATSSTQVSE FYERQASVN
Length:719
Mass (Da):81,417
Last modified:July 24, 2007 - v2
Checksum:i7A08F415B801CBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000496 Genomic DNA. Translation: ABN64436.2.
RefSeqiXP_001382465.2. XM_001382428.1.

Genome annotation databases

GeneIDi4837358.
KEGGipic:PICST_56005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000496 Genomic DNA. Translation: ABN64436.2.
RefSeqiXP_001382465.2. XM_001382428.1.

3D structure databases

ProteinModelPortaliA3LP53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322104.XP_001382465.2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4837358.
KEGGipic:PICST_56005.

Phylogenomic databases

InParanoidiA3LP53.
KOiK10747.
OMAiKSASTHN.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545Imported.

Entry informationi

Entry nameiA3LP53_PICST
AccessioniPrimary (citable) accession number: A3LP53
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: July 24, 2007
Last modified: July 22, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.