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Protein

DNA ligase

Gene

PICST_56005

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:PICST_56005Imported
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
Proteomesi
  • UP000002258 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi322104.XP_001382465.2

Structurei

3D structure databases

ProteinModelPortaliA3LP53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini461 – 598DNA_LIGASE_A3InterPro annotationAdd BLAST138

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili73 – 93Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
InParanoidiA3LP53
KOiK10747
OMAiWIKYKRD
OrthoDBiEOG092C0FHN

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A3LP53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRQQSIGR FFGSAMSVDS LLSQTVNKSP KNQKSESLTD EQNKREAFQV
60 70 80 90 100
SQQESEKDQE QKPDTDPSES EPEKDKTEEI KEASELIKLS EKEHEKHVGE
110 120 130 140 150
KLSAKIPYSK LTDVLDKIEA ESSRLKITAI VSEFFLEILK QSTVDKLVKI
160 170 180 190 200
VYLFINRLGP DYEPDLELGL GETILIKAIS ECYGRPSTKI KKDYQEVGDL
210 220 230 240 250
GLVAQKSRSG QPTMFKPAPL DVDQVFENLT KIAKSTGKDS QAKKISLINK
260 270 280 290 300
MLTACNAKSS EAKFLIRSLE GKLRIGLAEK TVLIGLAQAF VNYEAKDSKR
310 320 330 340 350
INPEKLTQSE DVVREAFSQI PNYEILIRNA YEYGIFNLLD HCQLTPGIPL
360 370 380 390 400
KPMLAKPTKS ISEVLDRFQG EEFTCEYKYD GERAQVHLLH DGTVRIYSRN
410 420 430 440 450
SEDMSERYPD LISIMKDFIK TQEGQAPSMI LDCEAVAWDR VANKILPFQV
460 470 480 490 500
LSTRKRKDVD EKDITVHICL FAFDILYFDN EPLITKSLKE RRQVMEENLT
510 520 530 540 550
PMDGKFQFAT AKNSSNLDEL QQFLDQSVKD SCEGLMVKML NGKESYYEPS
560 570 580 590 600
KRSRNWLKLK KDYLAGVGDS LDLVVIGAYI GRGKRTGNYG GFLLASYNQD
610 620 630 640 650
TGEYETTCKI GTGFSDEDLA SLHTKLKPTE ISVPKPYYVY DTTNSNAKPD
660 670 680 690 700
VWFEPTTIFE VLTADLSLSP IYKAAHQEYG KGISLRFPRF LRIRDDKGIE
710
DATSSTQVSE FYERQASVN
Length:719
Mass (Da):81,417
Last modified:July 24, 2007 - v2
Checksum:i7A08F415B801CBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000496 Genomic DNA Translation: ABN64436.2
RefSeqiXP_001382465.2, XM_001382428.1

Genome annotation databases

EnsemblFungiiABN64436; ABN64436; PICST_56005
GeneIDi4837358
KEGGipic:PICST_56005

Similar proteinsi

Entry informationi

Entry nameiA3LP53_PICST
AccessioniPrimary (citable) accession number: A3LP53
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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