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Protein

Mitogen-activated protein kinase HOG1

Gene

HOG1

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotation1
Active sitei144Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase HOG1 (EC:2.7.11.24)
Short name:
MAP kinase HOG1
Gene namesi
Name:HOG1
ORF Names:PICST_54431
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
Proteomesi
  • UP000002258 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002897001 – 385Mitogen-activated protein kinase HOG1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphothreonineBy similarity1
Modified residuei176PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-174 and Tyr-176, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi322104.XP_001382848.2

Structurei

3D structure databases

ProteinModelPortaliA3LN91
SMRiA3LN91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 305Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi174 – 176TXYBy similarity3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
InParanoidiA3LN91
KOiK04441
OMAiDVIDTIC
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR038783 MAPK_Sty1/Hog1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24055:SF247 PTHR24055:SF247, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A3LN91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDGEFTRT QIFGTVFEIT NRYTDLNPVG MGAFGLVCSA VDKLTGQNVA
60 70 80 90 100
VKKIMKPFST SVLAKRTYRE LKLLKHLKHE NLITLDDIFL SPLEDIYFVN
110 120 130 140 150
ELQGTDLHRL LTSRPLEKQF IQYFTYQILR GLKYIHSAGV IHRDLKPSNI
160 170 180 190 200
LINENCDLKI CDFGLARIQD PQMTGYVSTR YYRAPEIMLT WQKYDTEVDL
210 220 230 240 250
WSVGCILAEM IEGKPLFPGK DHVHQFSIIT ELLGSPPPDV IDTICSENTL
260 270 280 290 300
RFVQSLPHRD PIPFNERFAQ CTHVEPEAID LLAKMLIFDP KKRISAASAL
310 320 330 340 350
THPYMEPYHD PTDEPICETK FDWSFNDADL PVDTWRVMMY SEILDFHQIG
360 370 380
GVGEEAGQSV TQEEIAHIQQ DGIQAPQQPQ EQQVE
Length:385
Mass (Da):44,024
Last modified:July 24, 2007 - v2
Checksum:i7F3EB9BB7AD80556
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000496 Genomic DNA Translation: ABN64819.2
RefSeqiXP_001382848.2, XM_001382811.1

Genome annotation databases

EnsemblFungiiABN64819; ABN64819; PICST_54431
GeneIDi4837018
KEGGipic:PICST_54431

Similar proteinsi

Entry informationi

Entry nameiHOG1_PICST
AccessioniPrimary (citable) accession number: A3LN91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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