A3LMD4 (A3LMD4_PSEAI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 2 HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase 2 HAMAP MF_01123
Acyl-activating enzyme 2 HAMAP MF_01123

Gene names

Name:	acsA2 HAMAP MF_01123
ORF Names:	PA2G_06062 EMBL EAZ62615.1

Organism

Pseudomonas aeruginosa 2192 EMBL EAZ62615.1

Taxonomic identifier

350703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	651 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123
PTM	Acetylation HAMAP MF_01123
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	517	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	609	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	A3LMD4 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 991802723539AD23	FASTA	651	71,763
	10 20 30 40 50 60 MSAASLYPVH PEAVARTFTD EATYKTMYQQ SVVNPDGFWR EQAQRIDWIK PFEKVKQTSF 70 80 90 100 110 120 DDHHVDIKWF ADGTLNVSHN CLDRHLAERG DQVAIIWEGD DPADHQEITY RQLHEQVCKF 130 140 150 160 170 180 ANALRGQDVH RGDVVTIYMP MIPEAVVAML ACTRIGAIHS VVFGGFSPEA LAGRIIDCKS 190 200 210 220 230 240 KVVITADEGV RGGKRTPLKA NVDDALTNPE TSSVQKIIVC KRTGAEIKWN QHRDVWYDDL 250 260 270 280 290 300 MKVAGSTCAP KEMGAEDPLF ILYTSGSTGK PKGVLHTTGG YLVYASLTHE RVFDYRPGEV 310 320 330 340 350 360 YWCTADIGWV TGHTYIVYGP LANGATTILF EGVPNYPDVT RVAKIIDKHK VNILYTAPTA 370 380 390 400 410 420 IRAMMAEGKA AVAGADGSSL RLLGSVGEPI NPEAWQWYYE TVGQSRCPIV DTWWQTETGA 430 440 450 460 470 480 CLMTPLPGAH AMKPGSAAKP FFGVVPALVD NLGNLIEGAA EGNLVILDSW PGQARTLFGD 490 500 510 520 530 540 HDRFVDTYFK TFKGMYFTGD GARRDEDGYY WITGRVDDVL NVSGHRMGTA EVESAMVAHP 550 560 570 580 590 600 KVAEAAVVGM QHDIKGQGIY VYVTLNSGVE PSEALRQELK QWVRREIGPI ATPDVIQWAP 610 620 630 640 650 GLPKTRSGKI MRRILRKIAA AEYDTLGDIS TLADPGVVQH LIETHRSMQA A

References

[1]

"Dynamics of Pseudomonas aeruginosa genome evolution." Mathee K., Narasimhan G., Valdes C., Qiu X., Matewish J.M., Koehrsen M., Rokas A., Yandava C.N., Engels R., Zeng E., Olavarietta R., Doud M., Smith R.S., Montgomery P., White J.R., Godfrey P.A., Kodira C., Birren B., Galagan J.E., Lory S. Proc. Natl. Acad. Sci. U.S.A. 105:3100-3105(2008) [PubMed: 18287045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 2192 EMBL EAZ62615.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH482384 Genomic DNA. Translation: EAZ62615.1.
3D structure databases
ProteinModelPortal	A3LMD4.
SMR	A3LMD4. Positions 16-647.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	25562723. VBIPseAer126331_6349.
Phylogenomic databases
OMA	DYWWHEE.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A3LMD4_PSEAI

Accession

Primary (citable) accession number: A3LMD4

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)