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A3KPF5

- PDI15_ARATH

UniProt

A3KPF5 - PDI15_ARATH

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Protein

Protein disulfide isomerase-like 1-5

Gene

PDIL1-5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061NucleophileBy similarity
Active sitei447 – 4471NucleophileBy similarity
Active sitei450 – 4501NucleophileBy similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: TAIR

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. protein folding Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciARA:AT1G52260-MONOMER.
ReactomeiREACT_187630. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase-like 1-5 (EC:5.3.4.1)
Short name:
AtPDIL1-5
Alternative name(s):
Protein disulfide isomerase 3
Short name:
AtPDI3
Protein disulfide isomerase-like 3-1
Short name:
AtPDIL3-1
Gene namesi
Name:PDIL1-5
Synonyms:PDI3, PDIL3-1
Ordered Locus Names:At1g52260
ORF Names:F19K6.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G52260.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 537508Protein disulfide isomerase-like 1-5PRO_0000400020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi447 ↔ 450Redox-activePROSITE-ProRule annotation
Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA3KPF5.
PRIDEiA3KPF5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevestigatoriA3KPF5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G52260.1-P.

Structurei

3D structure databases

ProteinModelPortaliA3KPF5.
SMRiA3KPF5. Positions 79-528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 184127Thioredoxin 1PROSITE-ProRule annotationAdd
BLAST
Domaini380 – 526147Thioredoxin 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi534 – 5374Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000241706.
InParanoidiA3KPF5.
KOiK09580.
OMAiSANEHTK.
PhylomeDBiA3KPF5.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3KPF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLIPKPISK VSTFTFILLI LLSFTIIIAY SSPDSNVESN EPGFDSDLDQ
60 70 80 90 100
LLAVDEQLQE DRPEQQSEAE TVSKAQRIVL ELNGDYTKRV IDGNEFVMVL
110 120 130 140 150
GYAPWCARSA ELMPRFAEAA TALKEIGSSV LMAKIDGDRY SKIASELEIK
160 170 180 190 200
GFPTLLLFVN GTSLTYNGGS SAEDIVIWVQ KKTGAPIITL NTVDEAPRFL
210 220 230 240 250
DKYHTFVLGL FEKFEGSEHN EFVKAAKSDD EIQFIETRDS DVAKLLFPDL
260 270 280 290 300
KSNNVFIGLV KPEAERYTVY DGSYKMEKIL EFLGSNKFPL FTKLTETNTV
310 320 330 340 350
WVYSSPVKLQ VMLFSKADDF QKLAQPLEDI ARKFKSKLMF IYVDITNENL
360 370 380 390 400
AMPFLILFGI EAGNKTVVAA FDNNLNSKYL LESDPSPNSI EEFCSGLAHG
410 420 430 440 450
TVSRYYRSEP VPDNENASIV TVVGKTFDGL VLNSRENVLL EVHTPWCVNC
460 470 480 490 500
EALSKQIEKL AKHFKGFENL VFARIDASAN EHTKLQVDDK YPIILLYKSG
510 520 530
EKEKPLKLST KLSAKDIAVF INEELLKPKN GSAKDEL
Length:537
Mass (Da):60,158
Last modified:April 3, 2007 - v1
Checksum:i6380842BE6CFB1C4
GO

Sequence cautioni

The sequence AAG51554.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC037424 Genomic DNA. Translation: AAG51554.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32775.1.
BT030322 mRNA. Translation: ABO09885.1.
PIRiF96562.
RefSeqiNP_175636.2. NM_104105.2.
UniGeneiAt.49972.

Genome annotation databases

EnsemblPlantsiAT1G52260.1; AT1G52260.1; AT1G52260.
GeneIDi841656.
KEGGiath:AT1G52260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC037424 Genomic DNA. Translation: AAG51554.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE32775.1 .
BT030322 mRNA. Translation: ABO09885.1 .
PIRi F96562.
RefSeqi NP_175636.2. NM_104105.2.
UniGenei At.49972.

3D structure databases

ProteinModelPortali A3KPF5.
SMRi A3KPF5. Positions 79-528.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G52260.1-P.

Proteomic databases

PaxDbi A3KPF5.
PRIDEi A3KPF5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G52260.1 ; AT1G52260.1 ; AT1G52260 .
GeneIDi 841656.
KEGGi ath:AT1G52260.

Organism-specific databases

TAIRi AT1G52260.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000241706.
InParanoidi A3KPF5.
KOi K09580.
OMAi SANEHTK.
PhylomeDBi A3KPF5.

Enzyme and pathway databases

BioCyci ARA:AT1G52260-MONOMER.
Reactomei REACT_187630. XBP1(S) activates chaperone genes.

Gene expression databases

Genevestigatori A3KPF5.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
    Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
    Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. "Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana."
    Lu D.-P., Christopher D.A.
    Mol. Genet. Genomics 280:199-210(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
    d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
    BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPDI15_ARATH
AccessioniPrimary (citable) accession number: A3KPF5
Secondary accession number(s): Q9C818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3