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A3KPF5

- PDI15_ARATH

UniProt

A3KPF5 - PDI15_ARATH

Protein

Protein disulfide isomerase-like 1-5

Gene

PDIL1-5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.By similarity

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei106 – 1061NucleophileBy similarity
    Active sitei447 – 4471NucleophileBy similarity
    Active sitei450 – 4501NucleophileBy similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: TAIR

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. protein folding Source: GOC

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciARA:AT1G52260-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide isomerase-like 1-5 (EC:5.3.4.1)
    Short name:
    AtPDIL1-5
    Alternative name(s):
    Protein disulfide isomerase 3
    Short name:
    AtPDI3
    Protein disulfide isomerase-like 3-1
    Short name:
    AtPDIL3-1
    Gene namesi
    Name:PDIL1-5
    Synonyms:PDI3, PDIL3-1
    Ordered Locus Names:At1g52260
    ORF Names:F19K6.17
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G52260.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: TAIR
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 537508Protein disulfide isomerase-like 1-5PRO_0000400020Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi447 ↔ 450Redox-activePROSITE-ProRule annotation
    Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiA3KPF5.
    PRIDEiA3KPF5.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    GenevestigatoriA3KPF5.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G52260.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliA3KPF5.
    SMRiA3KPF5. Positions 61-528.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 184127Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini380 – 526147Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi534 – 5374Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000241706.
    InParanoidiA3KPF5.
    KOiK09580.
    OMAiSANEHTK.
    PhylomeDBiA3KPF5.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A3KPF5-1 [UniParc]FASTAAdd to Basket

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    MSLIPKPISK VSTFTFILLI LLSFTIIIAY SSPDSNVESN EPGFDSDLDQ    50
    LLAVDEQLQE DRPEQQSEAE TVSKAQRIVL ELNGDYTKRV IDGNEFVMVL 100
    GYAPWCARSA ELMPRFAEAA TALKEIGSSV LMAKIDGDRY SKIASELEIK 150
    GFPTLLLFVN GTSLTYNGGS SAEDIVIWVQ KKTGAPIITL NTVDEAPRFL 200
    DKYHTFVLGL FEKFEGSEHN EFVKAAKSDD EIQFIETRDS DVAKLLFPDL 250
    KSNNVFIGLV KPEAERYTVY DGSYKMEKIL EFLGSNKFPL FTKLTETNTV 300
    WVYSSPVKLQ VMLFSKADDF QKLAQPLEDI ARKFKSKLMF IYVDITNENL 350
    AMPFLILFGI EAGNKTVVAA FDNNLNSKYL LESDPSPNSI EEFCSGLAHG 400
    TVSRYYRSEP VPDNENASIV TVVGKTFDGL VLNSRENVLL EVHTPWCVNC 450
    EALSKQIEKL AKHFKGFENL VFARIDASAN EHTKLQVDDK YPIILLYKSG 500
    EKEKPLKLST KLSAKDIAVF INEELLKPKN GSAKDEL 537
    Length:537
    Mass (Da):60,158
    Last modified:April 3, 2007 - v1
    Checksum:i6380842BE6CFB1C4
    GO

    Sequence cautioni

    The sequence AAG51554.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC037424 Genomic DNA. Translation: AAG51554.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE32775.1.
    BT030322 mRNA. Translation: ABO09885.1.
    PIRiF96562.
    RefSeqiNP_175636.2. NM_104105.2.
    UniGeneiAt.49972.

    Genome annotation databases

    EnsemblPlantsiAT1G52260.1; AT1G52260.1; AT1G52260.
    GeneIDi841656.
    KEGGiath:AT1G52260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC037424 Genomic DNA. Translation: AAG51554.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE32775.1 .
    BT030322 mRNA. Translation: ABO09885.1 .
    PIRi F96562.
    RefSeqi NP_175636.2. NM_104105.2.
    UniGenei At.49972.

    3D structure databases

    ProteinModelPortali A3KPF5.
    SMRi A3KPF5. Positions 61-528.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G52260.1-P.

    Proteomic databases

    PaxDbi A3KPF5.
    PRIDEi A3KPF5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G52260.1 ; AT1G52260.1 ; AT1G52260 .
    GeneIDi 841656.
    KEGGi ath:AT1G52260.

    Organism-specific databases

    TAIRi AT1G52260.

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000241706.
    InParanoidi A3KPF5.
    KOi K09580.
    OMAi SANEHTK.
    PhylomeDBi A3KPF5.

    Enzyme and pathway databases

    BioCyci ARA:AT1G52260-MONOMER.

    Gene expression databases

    Genevestigatori A3KPF5.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Arabidopsis ORF clones."
      Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
      Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
      Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    5. "Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana."
      Lu D.-P., Christopher D.A.
      Mol. Genet. Genomics 280:199-210(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
      d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
      BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPDI15_ARATH
    AccessioniPrimary (citable) accession number: A3KPF5
    Secondary accession number(s): Q9C818
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2010
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3