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A3KPF5 (PDI15_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein disulfide isomerase-like 1-5

Short name=AtPDIL1-5
EC=5.3.4.1
Alternative name(s):
Protein disulfide isomerase 3
Short name=AtPDI3
Protein disulfide isomerase-like 3-1
Short name=AtPDIL3-1
Gene names
Name:PDIL1-5
Synonyms:PDI3, PDIL3-1
Ordered Locus Names:At1g52260
ORF Names:F19K6.17
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds By similarity.

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location

Endoplasmic reticulum lumen Probable.

Tissue specificity

Widely expressed. Ref.5

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 2 thioredoxin domains.

Sequence caution

The sequence AAG51554.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 537508Protein disulfide isomerase-like 1-5
PRO_0000400020

Regions

Domain58 – 184127Thioredoxin 1
Domain380 – 526147Thioredoxin 2
Motif534 – 5374Prevents secretion from ER By similarity

Sites

Active site1061Nucleophile By similarity
Active site4471Nucleophile By similarity
Active site4501Nucleophile By similarity

Amino acid modifications

Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation4161N-linked (GlcNAc...) Potential
Glycosylation5301N-linked (GlcNAc...) Potential
Disulfide bond447 ↔ 450Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
A3KPF5 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 6380842BE6CFB1C4

FASTA53760,158
        10         20         30         40         50         60 
MSLIPKPISK VSTFTFILLI LLSFTIIIAY SSPDSNVESN EPGFDSDLDQ LLAVDEQLQE 

        70         80         90        100        110        120 
DRPEQQSEAE TVSKAQRIVL ELNGDYTKRV IDGNEFVMVL GYAPWCARSA ELMPRFAEAA 

       130        140        150        160        170        180 
TALKEIGSSV LMAKIDGDRY SKIASELEIK GFPTLLLFVN GTSLTYNGGS SAEDIVIWVQ 

       190        200        210        220        230        240 
KKTGAPIITL NTVDEAPRFL DKYHTFVLGL FEKFEGSEHN EFVKAAKSDD EIQFIETRDS 

       250        260        270        280        290        300 
DVAKLLFPDL KSNNVFIGLV KPEAERYTVY DGSYKMEKIL EFLGSNKFPL FTKLTETNTV 

       310        320        330        340        350        360 
WVYSSPVKLQ VMLFSKADDF QKLAQPLEDI ARKFKSKLMF IYVDITNENL AMPFLILFGI 

       370        380        390        400        410        420 
EAGNKTVVAA FDNNLNSKYL LESDPSPNSI EEFCSGLAHG TVSRYYRSEP VPDNENASIV 

       430        440        450        460        470        480 
TVVGKTFDGL VLNSRENVLL EVHTPWCVNC EALSKQIEKL AKHFKGFENL VFARIDASAN 

       490        500        510        520        530 
EHTKLQVDDK YPIILLYKSG EKEKPLKLST KLSAKDIAVF INEELLKPKN GSAKDEL 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Arabidopsis ORF clones."
Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[5]"Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana."
Lu D.-P., Christopher D.A.
Mol. Genet. Genomics 280:199-210(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC037424 Genomic DNA. Translation: AAG51554.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32775.1.
BT030322 mRNA. Translation: ABO09885.1.
PIRF96562.
RefSeqNP_175636.2. NM_104105.2.
UniGeneAt.49972.

3D structure databases

ProteinModelPortalA3KPF5.
SMRA3KPF5. Positions 79-528.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT1G52260.1-P.

Proteomic databases

PaxDbA3KPF5.
PRIDEA3KPF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G52260.1; AT1G52260.1; AT1G52260.
GeneID841656.
KEGGath:AT1G52260.

Organism-specific databases

TAIRAT1G52260.

Phylogenomic databases

eggNOGCOG0526.
HOGENOMHOG000241706.
InParanoidA3KPF5.
KOK09580.
OMASANEHTK.
PhylomeDBA3KPF5.
ProtClustDBCLSN2680753.

Enzyme and pathway databases

BioCycARA:AT1G52260-MONOMER.

Gene expression databases

GenevestigatorA3KPF5.

Family and domain databases

Gene3D3.40.30.10. 3 hits.
InterProIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMSSF52833. SSF52833. 4 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDI15_ARATH
AccessionPrimary (citable) accession number: A3KPF5
Secondary accession number(s): Q9C818
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names