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Protein

Protein disulfide isomerase-like 1-5

Gene

PDIL1-5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106NucleophileBy similarity1
Active sitei447NucleophileBy similarity1
Active sitei450NucleophileBy similarity1

GO - Molecular functioni

  • protein disulfide isomerase activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-ATH-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase-like 1-5 (EC:5.3.4.1)
Short name:
AtPDIL1-5
Alternative name(s):
Protein disulfide isomerase 3
Short name:
AtPDI3
Protein disulfide isomerase-like 3-1
Short name:
AtPDIL3-1
Gene namesi
Name:PDIL1-5
Synonyms:PDI3, PDIL3-1
Ordered Locus Names:At1g52260
ORF Names:F19K6.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G52260
TAIRilocus:2018134 AT1G52260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000040002030 – 537Protein disulfide isomerase-like 1-5Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi447 ↔ 450Redox-activePROSITE-ProRule annotation
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA3KPF5
PRIDEiA3KPF5

PTM databases

iPTMnetiA3KPF5

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ExpressionAtlasiA3KPF5 baseline and differential
GenevisibleiA3KPF5 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G52260.1

Structurei

3D structure databases

ProteinModelPortaliA3KPF5
SMRiA3KPF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 184Thioredoxin 1PROSITE-ProRule annotationAdd BLAST127
Domaini380 – 526Thioredoxin 2PROSITE-ProRule annotationAdd BLAST147

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi534 – 537Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
HOGENOMiHOG000241706
InParanoidiA3KPF5
KOiK09580
OMAiKFEGPDY
OrthoDBiEOG093608OJ
PhylomeDBiA3KPF5

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 2 hits
SUPFAMiSSF52833 SSF52833, 4 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS51352 THIOREDOXIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3KPF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLIPKPISK VSTFTFILLI LLSFTIIIAY SSPDSNVESN EPGFDSDLDQ
60 70 80 90 100
LLAVDEQLQE DRPEQQSEAE TVSKAQRIVL ELNGDYTKRV IDGNEFVMVL
110 120 130 140 150
GYAPWCARSA ELMPRFAEAA TALKEIGSSV LMAKIDGDRY SKIASELEIK
160 170 180 190 200
GFPTLLLFVN GTSLTYNGGS SAEDIVIWVQ KKTGAPIITL NTVDEAPRFL
210 220 230 240 250
DKYHTFVLGL FEKFEGSEHN EFVKAAKSDD EIQFIETRDS DVAKLLFPDL
260 270 280 290 300
KSNNVFIGLV KPEAERYTVY DGSYKMEKIL EFLGSNKFPL FTKLTETNTV
310 320 330 340 350
WVYSSPVKLQ VMLFSKADDF QKLAQPLEDI ARKFKSKLMF IYVDITNENL
360 370 380 390 400
AMPFLILFGI EAGNKTVVAA FDNNLNSKYL LESDPSPNSI EEFCSGLAHG
410 420 430 440 450
TVSRYYRSEP VPDNENASIV TVVGKTFDGL VLNSRENVLL EVHTPWCVNC
460 470 480 490 500
EALSKQIEKL AKHFKGFENL VFARIDASAN EHTKLQVDDK YPIILLYKSG
510 520 530
EKEKPLKLST KLSAKDIAVF INEELLKPKN GSAKDEL
Length:537
Mass (Da):60,158
Last modified:April 3, 2007 - v1
Checksum:i6380842BE6CFB1C4
GO

Sequence cautioni

The sequence AAG51554 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC037424 Genomic DNA Translation: AAG51554.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32775.1
BT030322 mRNA Translation: ABO09885.1
PIRiF96562
RefSeqiNP_175636.2, NM_104105.3
UniGeneiAt.49972

Genome annotation databases

EnsemblPlantsiAT1G52260.1; AT1G52260.1; AT1G52260
GeneIDi841656
GrameneiAT1G52260.1; AT1G52260.1; AT1G52260
KEGGiath:AT1G52260

Similar proteinsi

Entry informationi

Entry nameiPDI15_ARATH
AccessioniPrimary (citable) accession number: A3KPF5
Secondary accession number(s): Q9C818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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