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A3KPA3

- NAA60_DANRE

UniProt

A3KPA3 - NAA60_DANRE

Protein

N-alpha-acetyltransferase 60

Gene

naa60

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. H4 histone acetyltransferase activity Source: UniProtKB
    2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. chromosome segregation Source: UniProtKB
    3. histone H4 acetylation Source: UniProtKB
    4. N-terminal peptidyl-methionine acetylation Source: UniProtKB
    5. nucleosome assembly Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Chromosome partition

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
    Alternative name(s):
    N-acetyltransferase 15
    NatF catalytic subunit
    Gene namesi
    Name:naa60
    Synonyms:nat15
    ORF Names:zgc:163109
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 3

    Organism-specific databases

    ZFINiZDB-GENE-041111-143. nat15.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321569Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA3KPA3.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000081428.

    Structurei

    3D structure databases

    ProteinModelPortaliA3KPA3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG276305.
    GeneTreeiENSGT00390000008314.
    HOGENOMiHOG000280717.
    HOVERGENiHBG061680.
    InParanoidiA3KPA3.
    OMAiTVKQLCG.
    OrthoDBiEOG7M0NT7.
    PhylomeDBiA3KPA3.
    TreeFamiTF323980.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3KPA3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDVVPTTAL SEIQLRLLCH DDIDRIKVLC GEWFPIEYPD SWYHDITSNK    50
    KFFSLAATFR GGIVGMIVAE IKSRTKVHKE DGDILASSFP VDTQVAYILS 100
    LGVVKEFRKH GIGSLLLDSL KEHISTTAQD HCKAIYLHVL TTNNTAIHFY 150
    ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI FDYIHHIGSA 200
    LASLSPCSIP QRIYRQAQNL LRSFLPWSGI SSKSGIEYSR TM 242
    Length:242
    Mass (Da):27,601
    Last modified:April 3, 2007 - v1
    Checksum:i8FC6B77734949A09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134236 mRNA. Translation: AAI34237.1.
    RefSeqiNP_001076341.1. NM_001082872.1.
    UniGeneiDr.159507.

    Genome annotation databases

    EnsembliENSDART00000086994; ENSDARP00000081428; ENSDARG00000061185.
    GeneIDi570640.
    KEGGidre:570640.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134236 mRNA. Translation: AAI34237.1 .
    RefSeqi NP_001076341.1. NM_001082872.1.
    UniGenei Dr.159507.

    3D structure databases

    ProteinModelPortali A3KPA3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000081428.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000086994 ; ENSDARP00000081428 ; ENSDARG00000061185 .
    GeneIDi 570640.
    KEGGi dre:570640.

    Organism-specific databases

    CTDi 570640.
    ZFINi ZDB-GENE-041111-143. nat15.

    Phylogenomic databases

    eggNOGi NOG276305.
    GeneTreei ENSGT00390000008314.
    HOGENOMi HOG000280717.
    HOVERGENi HBG061680.
    InParanoidi A3KPA3.
    OMAi TVKQLCG.
    OrthoDBi EOG7M0NT7.
    PhylomeDBi A3KPA3.
    TreeFami TF323980.

    Miscellaneous databases

    NextBioi 20890227.
    PROi A3KPA3.

    Gene expression databases

    Bgeei A3KPA3.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiNAA60_DANRE
    AccessioniPrimary (citable) accession number: A3KPA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3