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A3KPA3 (NAA60_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-alpha-acetyltransferase 60

EC=2.3.1.48
EC=2.3.1.88
Alternative name(s):
N-acetyltransferase 15
NatF catalytic subunit
Gene names
Name:naa60
Synonyms:nat15
ORF Names:zgc:163109
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.

Catalytic activity

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Golgi apparatus membrane By similarity.

Sequence similarities

Belongs to the acetyltransferase family. NAA60 subfamily.

Contains 1 N-acetyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242N-alpha-acetyltransferase 60
PRO_0000321569

Regions

Domain13 – 182170N-acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
A3KPA3 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 8FC6B77734949A09

FASTA24227,601
        10         20         30         40         50         60 
MTDVVPTTAL SEIQLRLLCH DDIDRIKVLC GEWFPIEYPD SWYHDITSNK KFFSLAATFR 

        70         80         90        100        110        120 
GGIVGMIVAE IKSRTKVHKE DGDILASSFP VDTQVAYILS LGVVKEFRKH GIGSLLLDSL 

       130        140        150        160        170        180 
KEHISTTAQD HCKAIYLHVL TTNNTAIHFY ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY 

       190        200        210        220        230        240 
INGGHPPWTI FDYIHHIGSA LASLSPCSIP QRIYRQAQNL LRSFLPWSGI SSKSGIEYSR 


TM 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC134236 mRNA. Translation: AAI34237.1.
RefSeqNP_001076341.1. NM_001082872.1.
UniGeneDr.159507.

3D structure databases

ProteinModelPortalA3KPA3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000081428.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000086994; ENSDARP00000081428; ENSDARG00000061185.
GeneID570640.
KEGGdre:570640.

Organism-specific databases

CTD570640.
ZFINZDB-GENE-041111-143. nat15.

Phylogenomic databases

eggNOGNOG276305.
GeneTreeENSGT00390000008314.
HOGENOMHOG000280717.
HOVERGENHBG061680.
InParanoidA3KPA3.
OMATVKQLCG.
OrthoDBEOG7M0NT7.
PhylomeDBA3KPA3.
TreeFamTF323980.

Gene expression databases

BgeeA3KPA3.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20890227.
PROA3KPA3.

Entry information

Entry nameNAA60_DANRE
AccessionPrimary (citable) accession number: A3KPA3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families