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A3KPA3

- NAA60_DANRE

UniProt

A3KPA3 - NAA60_DANRE

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Protein
N-alpha-acetyltransferase 60
Gene
naa60, nat15, zgc:163109
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.

Catalytic activityi

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: UniProtKB
  2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

GO - Biological processi

  1. N-terminal peptidyl-methionine acetylation Source: UniProtKB
  2. cell proliferation Source: UniProtKB
  3. chromosome segregation Source: UniProtKB
  4. histone H4 acetylation Source: UniProtKB
  5. nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
Alternative name(s):
N-acetyltransferase 15
NatF catalytic subunit
Gene namesi
Name:naa60
Synonyms:nat15
ORF Names:zgc:163109
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-041111-143. nat15.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242N-alpha-acetyltransferase 60
PRO_0000321569Add
BLAST

Expressioni

Gene expression databases

BgeeiA3KPA3.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000081428.

Structurei

3D structure databases

ProteinModelPortaliA3KPA3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 182170N-acetyltransferase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG276305.
GeneTreeiENSGT00390000008314.
HOGENOMiHOG000280717.
HOVERGENiHBG061680.
InParanoidiA3KPA3.
OMAiTVKQLCG.
OrthoDBiEOG7M0NT7.
PhylomeDBiA3KPA3.
TreeFamiTF323980.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3KPA3-1 [UniParc]FASTAAdd to Basket

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MTDVVPTTAL SEIQLRLLCH DDIDRIKVLC GEWFPIEYPD SWYHDITSNK    50
KFFSLAATFR GGIVGMIVAE IKSRTKVHKE DGDILASSFP VDTQVAYILS 100
LGVVKEFRKH GIGSLLLDSL KEHISTTAQD HCKAIYLHVL TTNNTAIHFY 150
ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI FDYIHHIGSA 200
LASLSPCSIP QRIYRQAQNL LRSFLPWSGI SSKSGIEYSR TM 242
Length:242
Mass (Da):27,601
Last modified:April 3, 2007 - v1
Checksum:i8FC6B77734949A09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC134236 mRNA. Translation: AAI34237.1.
RefSeqiNP_001076341.1. NM_001082872.1.
UniGeneiDr.159507.

Genome annotation databases

EnsembliENSDART00000086994; ENSDARP00000081428; ENSDARG00000061185.
GeneIDi570640.
KEGGidre:570640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC134236 mRNA. Translation: AAI34237.1 .
RefSeqi NP_001076341.1. NM_001082872.1.
UniGenei Dr.159507.

3D structure databases

ProteinModelPortali A3KPA3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000081428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000086994 ; ENSDARP00000081428 ; ENSDARG00000061185 .
GeneIDi 570640.
KEGGi dre:570640.

Organism-specific databases

CTDi 570640.
ZFINi ZDB-GENE-041111-143. nat15.

Phylogenomic databases

eggNOGi NOG276305.
GeneTreei ENSGT00390000008314.
HOGENOMi HOG000280717.
HOVERGENi HBG061680.
InParanoidi A3KPA3.
OMAi TVKQLCG.
OrthoDBi EOG7M0NT7.
PhylomeDBi A3KPA3.
TreeFami TF323980.

Miscellaneous databases

NextBioi 20890227.
PROi A3KPA3.

Gene expression databases

Bgeei A3KPA3.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNAA60_DANRE
AccessioniPrimary (citable) accession number: A3KPA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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