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Protein

N-alpha-acetyltransferase 60

Gene

naa60

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
Alternative name(s):
N-acetyltransferase 15
NatF catalytic subunit
Gene namesi
Name:naa60
Synonyms:nat15
ORF Names:zgc:163109
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-041111-143. nat15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321569Add
BLAST

Expressioni

Gene expression databases

BgeeiA3KPA3.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000081428.

Structurei

3D structure databases

ProteinModelPortaliA3KPA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG276305.
GeneTreeiENSGT00390000008314.
HOGENOMiHOG000280717.
HOVERGENiHBG061680.
InParanoidiA3KPA3.
OMAiTVKQLCG.
OrthoDBiEOG7M0NT7.
PhylomeDBiA3KPA3.
TreeFamiTF323980.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3KPA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVVPTTAL SEIQLRLLCH DDIDRIKVLC GEWFPIEYPD SWYHDITSNK
60 70 80 90 100
KFFSLAATFR GGIVGMIVAE IKSRTKVHKE DGDILASSFP VDTQVAYILS
110 120 130 140 150
LGVVKEFRKH GIGSLLLDSL KEHISTTAQD HCKAIYLHVL TTNNTAIHFY
160 170 180 190 200
ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI FDYIHHIGSA
210 220 230 240
LASLSPCSIP QRIYRQAQNL LRSFLPWSGI SSKSGIEYSR TM
Length:242
Mass (Da):27,601
Last modified:April 3, 2007 - v1
Checksum:i8FC6B77734949A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134236 mRNA. Translation: AAI34237.1.
RefSeqiNP_001076341.1. NM_001082872.1.
UniGeneiDr.159507.

Genome annotation databases

EnsembliENSDART00000086994; ENSDARP00000081428; ENSDARG00000061185.
GeneIDi570640.
KEGGidre:570640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134236 mRNA. Translation: AAI34237.1.
RefSeqiNP_001076341.1. NM_001082872.1.
UniGeneiDr.159507.

3D structure databases

ProteinModelPortaliA3KPA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000081428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000086994; ENSDARP00000081428; ENSDARG00000061185.
GeneIDi570640.
KEGGidre:570640.

Organism-specific databases

CTDi570640.
ZFINiZDB-GENE-041111-143. nat15.

Phylogenomic databases

eggNOGiNOG276305.
GeneTreeiENSGT00390000008314.
HOGENOMiHOG000280717.
HOVERGENiHBG061680.
InParanoidiA3KPA3.
OMAiTVKQLCG.
OrthoDBiEOG7M0NT7.
PhylomeDBiA3KPA3.
TreeFamiTF323980.

Miscellaneous databases

NextBioi20890227.
PROiA3KPA3.

Gene expression databases

BgeeiA3KPA3.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNAA60_DANRE
AccessioniPrimary (citable) accession number: A3KPA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 3, 2007
Last modified: January 7, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.