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Protein
Submitted name:

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

Gene

skp2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-DRE-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DRE-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DRE-5689880 Ub-specific processing proteases
R-DRE-69231 Cyclin D associated events in G1
R-DRE-8939902 Regulation of RUNX2 expression and activity
R-DRE-8951664 Neddylation
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
S-phase kinase-associated protein 2, E3 ubiquitin protein ligaseImported
Submitted name:
Skp2 proteinImported
Gene namesi
Name:skp2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-030219-158 skp2

Expressioni

Gene expression databases

BgeeiENSDARG00000004937

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092527

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 131F-boxInterPro annotationAdd BLAST47

Phylogenomic databases

eggNOGiKOG2120 Eukaryota
ENOG410Z2W2 LUCA
GeneTreeiENSGT00390000007918
HOGENOMiHOG000247037
HOVERGENiHBG047488
KOiK03875
OMAiEIWGIRC
OrthoDBiEOG091G0EYN
TreeFamiTF352582

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 5 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

A3KP53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNERVFQEL SENLEGSLCR SQRTKWKKRP SCSSGLDTEN TPNELIQQWS
60 70 80 90 100
PPHKKALTTA KGKENEENLF VLARRPRKRR ESSANLCWDS LPDELLLGIF
110 120 130 140 150
SRLSLQDLLR TSRVCKRWHR LAFDESLWHS VDLVGKAQLD AELGQVLSAG
160 170 180 190 200
VLRLRCPHTC IGQPSFKSTP SLRVQHLDFS NCTVETSVLE DVLSRCKHLQ
210 220 230 240 250
NLSLEGLVLS DNIIYSLAQN PEIIRLNLCG CSGFSPESLT EMLTACTRIE
260 270 280 290 300
EMNVSWCDFS NLHIQAIASN IPSSVSQLNI SGYRQNLTME DVKAIVKRCP
310 320 330 340 350
NITDLDLSDS VLVTTDSFPV LQQLSSLRHL GLSRCYQIHP ASLIDFEKFL
360 370 380 390 400
NLQTLEVFGL IQDSYLPILC KSLPHIQINT QPFSTVARPT SSSRKDRTLW
410
GMHCRLVYKH
Length:410
Mass (Da):46,433
Last modified:April 3, 2007 - v1
Checksum:i5DE47B0D549E3361
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470072 Genomic DNA No translation available.
BC134165 mRNA Translation: AAI34166.1
RefSeqiNP_001076306.1, NM_001082837.2
UniGeneiDr.72345

Genome annotation databases

EnsembliENSDART00000101751; ENSDARP00000092527; ENSDARG00000004937
GeneIDi563708
KEGGidre:563708

Similar proteinsi

Entry informationi

Entry nameiA3KP53_DANRE
AccessioniPrimary (citable) accession number: A3KP53
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health