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Protein

Protein strawberry notch homolog 1

Gene

SBNO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein strawberry notch homolog 1
Alternative name(s):
Monocyte protein 3
Short name:
MOP-3
Gene namesi
Name:SBNO1
Synonyms:MOP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139697.11
HGNCiHGNC:22973 SBNO1
neXtProtiNX_A3KN83

Pathology & Biotechi

Organism-specific databases

DisGeNETi55206
OpenTargetsiENSG00000139697
PharmGKBiPA134967986

Polymorphism and mutation databases

BioMutaiSBNO1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003145551 – 1393Protein strawberry notch homolog 1Add BLAST1393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148PhosphoserineCombined sources1
Modified residuei149N6-acetyllysineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei413N6-acetyllysineCombined sources1
Modified residuei692PhosphoserineBy similarity1
Modified residuei693PhosphoserineBy similarity1
Modified residuei697PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1
Modified residuei768PhosphoserineBy similarity1
Modified residuei794PhosphoserineCombined sources1
Modified residuei815PhosphoserineCombined sources1
Modified residuei1222N6-acetyllysineCombined sources1
Modified residuei1386PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiA3KN83
MaxQBiA3KN83
PaxDbiA3KN83
PRIDEiA3KN83

PTM databases

iPTMnetiA3KN83
PhosphoSitePlusiA3KN83

Expressioni

Gene expression databases

BgeeiENSG00000139697
CleanExiHS_SBNO1
GenevisibleiA3KN83 HS

Organism-specific databases

HPAiHPA042388

Interactioni

Protein-protein interaction databases

BioGridi120502, 20 interactors
IntActiA3KN83, 2 interactors
STRINGi9606.ENSP00000387361

Structurei

3D structure databases

ProteinModelPortaliA3KN83
SMRiA3KN83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili843 – 870Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi784 – 793Poly-Lys10

Sequence similaritiesi

Belongs to the SBNO family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1513 Eukaryota
ENOG410XQ7Q LUCA
GeneTreeiENSGT00390000016591
HOGENOMiHOG000043949
HOVERGENiHBG108461
InParanoidiA3KN83
OMAiRMWINDM
OrthoDBiEOG091G00L4
PhylomeDBiA3KN83
TreeFamiTF313526

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR026937 SBNO_Helicase_C_dom
IPR026741 SNO
PANTHERiPTHR12706 PTHR12706, 1 hit
PfamiView protein in Pfam
PF13871 Helicase_C_4, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A3KN83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEPGQDLLL AALSESGISP NDLFDIDGGD AGLATPMPTP SVQQSVPLSA
60 70 80 90 100
LELGLETEAA VPVKQEPETV PTPALLNVRQ QPPSTTTFVL NQINHLPPLG
110 120 130 140 150
STIVMTKTPP VTTNRQTITL TKFIQTTAST RPSVSAPTVR NAMTSAPSKD
160 170 180 190 200
QVQLKDLLKN NSLNELMKLK PPANIAQPVA TAATDVSNGT VKKESSNKEG
210 220 230 240 250
ARMWINDMKM RSFSPTMKVP VVKEDDEPEE EDEEEMGHAE TYAEYMPIKL
260 270 280 290 300
KIGLRHPDAV VETSSLSSVT PPDVWYKTSI SEETIDNGWL SALQLEAITY
310 320 330 340 350
AAQQHETFLP NGDRAGFLIG DGAGVGKGRT IAGIIYENYL LSRKRALWFS
360 370 380 390 400
VSNDLKYDAE RDLRDIGAKN ILVHSLNKFK YGKISSKHNG SVKKGVIFAT
410 420 430 440 450
YSSLIGESQS GGKYKTRLKQ LLHWCGDDFD GVIVFDECHK AKNLCPVGSS
460 470 480 490 500
KPTKTGLAVL ELQNKLPKAR VVYASATGAS EPRNMAYMNR LGIWGEGTPF
510 520 530 540 550
REFSDFIQAV ERRGVGAMEI VAMDMKLRGM YIARQLSFTG VTFKIEEVLL
560 570 580 590 600
SQSYVKMYNK AVKLWVIARE RFQQAADLID AEQRMKKSMW GQFWSAHQRF
610 620 630 640 650
FKYLCIASKV KRVVQLAREE IKNGKCVVIG LQSTGEARTL EALEEGGGEL
660 670 680 690 700
NDFVSTAKGV LQSLIEKHFP APDRKKLYSL LGIDLTAPSN NSSPRDSPCK
710 720 730 740 750
ENKIKKRKGE EITREAKKAR KVGGLTGSSS DDSGSESDAS DNEESDYESS
760 770 780 790 800
KNMSSGDDDD FNPFLDESNE DDENDPWLIR KDHKKNKEKK KKKSIDPDSI
810 820 830 840 850
QSALLASGLG SKRPSFSSTP VISPAPNSTP ANSNTNSNSS LITSQDAVER
860 870 880 890 900
AQQMKKDLLD KLEKLAEDLP PNTLDELIDE LGGPENVAEM TGRKGRVVSN
910 920 930 940 950
DDGSISYESR SELDVPVEIL NITEKQRFMD GDKNIAIISE AASSGISLQA
960 970 980 990 1000
DRRAKNQRRR VHMTLELPWS ADRAIQQFGR THRSNQVTAP EYVFLISELA
1010 1020 1030 1040 1050
GEQRFASIVA KRLESLGALT HGDRRATESR DLSRFNFDNK YGRNALEIVM
1060 1070 1080 1090 1100
KSIVNLDSPM VSPPPDYPGE FFKDVRQGLI GVGLINVEDR SGILTLDKDY
1110 1120 1130 1140 1150
NNIGKFLNRI LGMEVHQQNA LFQYFADTLT AVVQNAKKNG RYDMGILDLG
1160 1170 1180 1190 1200
SGDEKVRKSD VKKFLTPGYS TSGHVELYTI SVERGMSWEE ATKIWAELTG
1210 1220 1230 1240 1250
PDDGFYLSLQ IRNNKKTAIL VKEVNPKKKL FLVYRPNTGK QLKLEIYADL
1260 1270 1280 1290 1300
KKKYKKVVSD DALMHWLDQY NSSADTCTHA YWRGNCKKAS LGLVCEIGLR
1310 1320 1330 1340 1350
CRTYYVLCGS VLSVWTKVEG VLASVSGTNV KMQIVRLRTE DGQRIVGLII
1360 1370 1380 1390
PANCVSPLVN LLSTSDQSQQ LAVQQKQLWQ QHHPQSITNL SNA
Length:1,393
Mass (Da):154,312
Last modified:April 3, 2007 - v1
Checksum:iD2C42F29C7EEC20D
GO
Isoform 2 (identifier: A3KN83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-81: QQ → Q

Note: No experimental confirmation available.
Show »
Length:1,392
Mass (Da):154,184
Checksum:i4CB83A00B1DBEC22
GO
Isoform 3 (identifier: A3KN83-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-79: Missing.

Note: No experimental confirmation available.
Show »
Length:1,391
Mass (Da):154,057
Checksum:i3682A9E4AB3A70E2
GO
Isoform 4 (identifier: A3KN83-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-81: QQ → Q
     722-733: VGGLTGSSSDDS → MSLMRMMKMIPG
     734-1393: Missing.

Note: No experimental confirmation available.
Show »
Length:732
Mass (Da):80,852
Checksum:i28DAA87F2379ABE5
GO

Sequence cautioni

The sequence AAQ76814 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4P → Q in AAQ76814 (PubMed:16533400).Curated1
Sequence conflicti14S → R in BAA91842 (PubMed:14702039).Curated1
Sequence conflicti555V → A in AAQ76814 (PubMed:16533400).Curated1
Sequence conflicti774N → S in BAB19784 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037910634T → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_037911728S → N. Corresponds to variant dbSNP:rs1060105Ensembl.1
Natural variantiVAR_057794729S → N. Corresponds to variant dbSNP:rs1060105Ensembl.1
Natural variantiVAR_037912889E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_037913997S → C in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03029578 – 79Missing in isoform 3. 1 Publication2
Alternative sequenceiVSP_03029680 – 81QQ → Q in isoform 2 and isoform 4. 3 Publications2
Alternative sequenceiVSP_030297722 – 733VGGLT…SSDDS → MSLMRMMKMIPG in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_030298734 – 1393Missing in isoform 4. 1 PublicationAdd BLAST660

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014772 mRNA Translation: BAB19784.1
BC030544 mRNA Translation: AAH30544.1
BC133704 mRNA Translation: AAI33705.1
AK001695 mRNA Translation: BAA91842.1
AY364255 mRNA Translation: AAQ76814.1 Different initiation.
CCDSiCCDS53844.1 [A3KN83-1]
CCDS9246.1 [A3KN83-2]
RefSeqiNP_001161328.1, NM_001167856.2 [A3KN83-1]
NP_060653.3, NM_018183.4 [A3KN83-2]
XP_005253630.1, XM_005253573.4 [A3KN83-1]
XP_005253633.1, XM_005253576.3 [A3KN83-2]
XP_006719536.1, XM_006719473.3 [A3KN83-1]
XP_006719537.1, XM_006719474.3 [A3KN83-1]
XP_011536835.1, XM_011538533.2 [A3KN83-2]
XP_016875045.1, XM_017019556.1 [A3KN83-3]
UniGeneiHs.7012

Genome annotation databases

EnsembliENST00000267176; ENSP00000267176; ENSG00000139697 [A3KN83-2]
ENST00000420886; ENSP00000387361; ENSG00000139697 [A3KN83-1]
ENST00000602398; ENSP00000473665; ENSG00000139697 [A3KN83-1]
GeneIDi55206
KEGGihsa:55206
UCSCiuc010tao.3 human [A3KN83-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSBNO1_HUMAN
AccessioniPrimary (citable) accession number: A3KN83
Secondary accession number(s): Q05C06
, Q3ZTS3, Q9H3T8, Q9NVB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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