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A3KN83 (SBNO1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein strawberry notch homolog 1
Alternative name(s):
Monocyte protein 3
Short name=MOP-3
Gene names
Name:SBNO1
Synonyms:MOP3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1393 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the SBNO family.

Sequence caution

The sequence AAQ76814.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A3KN83-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A3KN83-2)

The sequence of this isoform differs from the canonical sequence as follows:
     80-81: QQ → Q
Note: No experimental confirmation available.
Isoform 3 (identifier: A3KN83-3)

The sequence of this isoform differs from the canonical sequence as follows:
     78-79: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: A3KN83-4)

The sequence of this isoform differs from the canonical sequence as follows:
     80-81: QQ → Q
     722-733: VGGLTGSSSDDS → MSLMRMMKMIPG
     734-1393: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13931393Protein strawberry notch homolog 1
PRO_0000314555

Regions

Coiled coil843 – 87028 Potential
Compositional bias784 – 79310Poly-Lys

Amino acid modifications

Modified residue1491N6-acetyllysine Ref.8
Modified residue2141Phosphoserine Ref.6
Modified residue4131N6-acetyllysine Ref.8
Modified residue6971Phosphoserine Ref.5
Modified residue7541Phosphoserine Ref.9 Ref.11
Modified residue7551Phosphoserine Ref.9 Ref.11
Modified residue7941Phosphoserine Ref.6 Ref.7 Ref.9
Modified residue8151Phosphoserine Ref.7
Modified residue12221N6-acetyllysine Ref.8

Natural variations

Alternative sequence78 – 792Missing in isoform 3.
VSP_030295
Alternative sequence80 – 812QQ → Q in isoform 2 and isoform 4.
VSP_030296
Alternative sequence722 – 73312VGGLT…SSDDS → MSLMRMMKMIPG in isoform 4.
VSP_030297
Alternative sequence734 – 1393660Missing in isoform 4.
VSP_030298
Natural variant6341T → S in a breast cancer sample; somatic mutation. Ref.12
VAR_037910
Natural variant7281S → N.
Corresponds to variant rs1060105 [ dbSNP | Ensembl ].
VAR_037911
Natural variant7291S → N.
Corresponds to variant rs1060105 [ dbSNP | Ensembl ].
VAR_057794
Natural variant8891E → K in a breast cancer sample; somatic mutation. Ref.12
VAR_037912
Natural variant9971S → C in a breast cancer sample; somatic mutation. Ref.12
VAR_037913

Experimental info

Sequence conflict41P → Q in AAQ76814. Ref.4
Sequence conflict141S → R in BAA91842. Ref.3
Sequence conflict5551V → A in AAQ76814. Ref.4
Sequence conflict7741N → S in BAB19784. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: D2C42F29C7EEC20D

FASTA1,393154,312
        10         20         30         40         50         60 
MVEPGQDLLL AALSESGISP NDLFDIDGGD AGLATPMPTP SVQQSVPLSA LELGLETEAA 

        70         80         90        100        110        120 
VPVKQEPETV PTPALLNVRQ QPPSTTTFVL NQINHLPPLG STIVMTKTPP VTTNRQTITL 

       130        140        150        160        170        180 
TKFIQTTAST RPSVSAPTVR NAMTSAPSKD QVQLKDLLKN NSLNELMKLK PPANIAQPVA 

       190        200        210        220        230        240 
TAATDVSNGT VKKESSNKEG ARMWINDMKM RSFSPTMKVP VVKEDDEPEE EDEEEMGHAE 

       250        260        270        280        290        300 
TYAEYMPIKL KIGLRHPDAV VETSSLSSVT PPDVWYKTSI SEETIDNGWL SALQLEAITY 

       310        320        330        340        350        360 
AAQQHETFLP NGDRAGFLIG DGAGVGKGRT IAGIIYENYL LSRKRALWFS VSNDLKYDAE 

       370        380        390        400        410        420 
RDLRDIGAKN ILVHSLNKFK YGKISSKHNG SVKKGVIFAT YSSLIGESQS GGKYKTRLKQ 

       430        440        450        460        470        480 
LLHWCGDDFD GVIVFDECHK AKNLCPVGSS KPTKTGLAVL ELQNKLPKAR VVYASATGAS 

       490        500        510        520        530        540 
EPRNMAYMNR LGIWGEGTPF REFSDFIQAV ERRGVGAMEI VAMDMKLRGM YIARQLSFTG 

       550        560        570        580        590        600 
VTFKIEEVLL SQSYVKMYNK AVKLWVIARE RFQQAADLID AEQRMKKSMW GQFWSAHQRF 

       610        620        630        640        650        660 
FKYLCIASKV KRVVQLAREE IKNGKCVVIG LQSTGEARTL EALEEGGGEL NDFVSTAKGV 

       670        680        690        700        710        720 
LQSLIEKHFP APDRKKLYSL LGIDLTAPSN NSSPRDSPCK ENKIKKRKGE EITREAKKAR 

       730        740        750        760        770        780 
KVGGLTGSSS DDSGSESDAS DNEESDYESS KNMSSGDDDD FNPFLDESNE DDENDPWLIR 

       790        800        810        820        830        840 
KDHKKNKEKK KKKSIDPDSI QSALLASGLG SKRPSFSSTP VISPAPNSTP ANSNTNSNSS 

       850        860        870        880        890        900 
LITSQDAVER AQQMKKDLLD KLEKLAEDLP PNTLDELIDE LGGPENVAEM TGRKGRVVSN 

       910        920        930        940        950        960 
DDGSISYESR SELDVPVEIL NITEKQRFMD GDKNIAIISE AASSGISLQA DRRAKNQRRR 

       970        980        990       1000       1010       1020 
VHMTLELPWS ADRAIQQFGR THRSNQVTAP EYVFLISELA GEQRFASIVA KRLESLGALT 

      1030       1040       1050       1060       1070       1080 
HGDRRATESR DLSRFNFDNK YGRNALEIVM KSIVNLDSPM VSPPPDYPGE FFKDVRQGLI 

      1090       1100       1110       1120       1130       1140 
GVGLINVEDR SGILTLDKDY NNIGKFLNRI LGMEVHQQNA LFQYFADTLT AVVQNAKKNG 

      1150       1160       1170       1180       1190       1200 
RYDMGILDLG SGDEKVRKSD VKKFLTPGYS TSGHVELYTI SVERGMSWEE ATKIWAELTG 

      1210       1220       1230       1240       1250       1260 
PDDGFYLSLQ IRNNKKTAIL VKEVNPKKKL FLVYRPNTGK QLKLEIYADL KKKYKKVVSD 

      1270       1280       1290       1300       1310       1320 
DALMHWLDQY NSSADTCTHA YWRGNCKKAS LGLVCEIGLR CRTYYVLCGS VLSVWTKVEG 

      1330       1340       1350       1360       1370       1380 
VLASVSGTNV KMQIVRLRTE DGQRIVGLII PANCVSPLVN LLSTSDQSQQ LAVQQKQLWQ 

      1390 
QHHPQSITNL SNA 

« Hide

Isoform 2 [UniParc].

Checksum: 4CB83A00B1DBEC22
Show »

FASTA1,392154,184
Isoform 3 [UniParc].

Checksum: 3682A9E4AB3A70E2
Show »

FASTA1,391154,057
Isoform 4 [UniParc].

Checksum: 28DAA87F2379ABE5
Show »

FASTA73280,852

References

« Hide 'large scale' references
[1]"Molecular and biological characterization of a new nuclear protein, MOP-3 which is highly expressed in human monocytes."
Takayama K., Ukai Y., Fujii Y., Yoshimoto M.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Blood.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-793 (ISOFORM 3).
Tissue: Placenta.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-783 (ISOFORM 2).
Tissue: Teratocarcinoma.
[4]"NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P., Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W.
BMC Genomics 7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-1393 (ISOFORM 4).
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-697, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214 AND SER-794, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-794 AND SER-815, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-149; LYS-413 AND LYS-1222, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754; SER-755 AND SER-794, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754 AND SER-755, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-634; LYS-889 AND CYS-997.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB014772 mRNA. Translation: BAB19784.1.
BC030544 mRNA. Translation: AAH30544.1.
BC133704 mRNA. Translation: AAI33705.1.
AK001695 mRNA. Translation: BAA91842.1.
AY364255 mRNA. Translation: AAQ76814.1. Different initiation.
RefSeqNP_001161328.1. NM_001167856.1.
NP_060653.3. NM_018183.3.
XP_005253629.1. XM_005253572.1.
XP_005253630.1. XM_005253573.2.
XP_005253632.1. XM_005253575.1.
XP_005253633.1. XM_005253576.1.
UniGeneHs.7012.

3D structure databases

ProteinModelPortalA3KN83.
SMRA3KN83. Positions 925-996.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120502. 5 interactions.
IntActA3KN83. 1 interaction.
STRING9606.ENSP00000267176.

PTM databases

PhosphoSiteA3KN83.

Proteomic databases

PaxDbA3KN83.
PeptideAtlasA3KN83.
PRIDEA3KN83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267176; ENSP00000267176; ENSG00000139697. [A3KN83-2]
ENST00000420886; ENSP00000387361; ENSG00000139697. [A3KN83-1]
ENST00000602398; ENSP00000473665; ENSG00000139697. [A3KN83-1]
ENST00000602750; ENSP00000473480; ENSG00000139697. [A3KN83-2]
GeneID55206.
KEGGhsa:55206.
UCSCuc001uet.2. human. [A3KN83-1]
uc001ueu.2. human. [A3KN83-2]
uc001uev.2. human. [A3KN83-3]

Organism-specific databases

CTD55206.
GeneCardsGC12M123774.
HGNCHGNC:22973. SBNO1.
HPAHPA042388.
neXtProtNX_A3KN83.
PharmGKBPA134967986.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83182.
HOGENOMHOG000043949.
HOVERGENHBG108461.
InParanoidA3KN83.
OMAKQLWQQR.
OrthoDBEOG70PBWM.
PhylomeDBA3KN83.
TreeFamTF313526.

Gene expression databases

ArrayExpressA3KN83.
BgeeA3KN83.
CleanExHS_SBNO1.
GenevestigatorA3KN83.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR026937. SBNO_Helicase_C_dom.
IPR026741. SNO.
[Graphical view]
PANTHERPTHR12706. PTHR12706. 1 hit.
PfamPF13871. Helicase_C_4. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
ProtoNetSearch...

Other

ChiTaRSSBNO1. human.
GenomeRNAi55206.
NextBio59106.
PROA3KN83.

Entry information

Entry nameSBNO1_HUMAN
AccessionPrimary (citable) accession number: A3KN83
Secondary accession number(s): Q05C06 expand/collapse secondary AC list , Q3ZTS3, Q9H3T8, Q9NVB2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM