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Protein

LETM1 domain-containing protein 1

Gene

LETMD1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a negative regulator of the p53/TP53.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 domain-containing protein 1
Gene namesi
Name:LETMD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 137CytoplasmicSequence analysisAdd BLAST137
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 360Mitochondrial intermembraneSequence analysisAdd BLAST202

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104181 – 360LETM1 domain-containing protein 1Add BLAST360

Proteomic databases

PaxDbiA3KN46.
PRIDEiA3KN46.

Interactioni

Subunit structurei

Interacts with BRI3BP.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038354.

Structurei

3D structure databases

ProteinModelPortaliA3KN46.
SMRiA3KN46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 360Letm1 RBDPROSITE-ProRule annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 110Required and sufficient for mitochondrial importBy similarityAdd BLAST110

Sequence similaritiesi

Contains 1 Letm1 RBD (ribosome-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4263. Eukaryota.
ENOG410ZXCM. LUCA.
HOGENOMiHOG000037443.
HOVERGENiHBG108107.
InParanoidiA3KN46.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3KN46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSRVCWAR AALWGSAVPP GLYVVRRLQF VRSGLTWGAP RSSKLHLSPK
60 70 80 90 100
ADVKSLISYV VTKTKVINGK YHRFLGRHFP RFYVPYTIFM KGLQMLWADG
110 120 130 140 150
KKARRIKTNM WKHNIKFHQL PYREMEHLRQ FRRDVTKCLF LGILSIPPFA
160 170 180 190 200
NYLVFLLMYL FPRQLLIRHF WTPKQQIDFL DIYHALRKQS HPEILCYLEK
210 220 230 240 250
VVPLISDAGL QWHMTELCTK MQRGTHPAVH DILALRECFA NHPLGMDQLR
260 270 280 290 300
ALQMKALCRA MLLTPYLPSV LLRHRLKTHT TVIHQLDKAL AKLGVGQLTA
310 320 330 340 350
QEVKSACYLR GLNSTHIAEE RCRTWLGEWL QISCSLKETE LSLLLHNVVL
360
LSINYVGSRR
Length:360
Mass (Da):41,913
Last modified:April 3, 2007 - v1
Checksum:iEC738395E9A1AD31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133596 mRNA. Translation: AAI33597.1.
RefSeqiNP_001076899.1. NM_001083430.1.
UniGeneiBt.24718.

Genome annotation databases

GeneIDi514595.
KEGGibta:514595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133596 mRNA. Translation: AAI33597.1.
RefSeqiNP_001076899.1. NM_001083430.1.
UniGeneiBt.24718.

3D structure databases

ProteinModelPortaliA3KN46.
SMRiA3KN46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038354.

Proteomic databases

PaxDbiA3KN46.
PRIDEiA3KN46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514595.
KEGGibta:514595.

Organism-specific databases

CTDi25875.

Phylogenomic databases

eggNOGiKOG4263. Eukaryota.
ENOG410ZXCM. LUCA.
HOGENOMiHOG000037443.
HOVERGENiHBG108107.
InParanoidiA3KN46.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLTMD1_BOVIN
AccessioniPrimary (citable) accession number: A3KN46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.