Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor MafA

Gene

mafa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a transcription factor.

GO - Molecular functioni

  • DNA binding transcription factor activity Source: InterPro
  • sequence-specific DNA binding Source: ZFIN

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafA
Alternative name(s):
Somite Maf1
Short name:
SMaf1
Gene namesi
Name:mafa
Synonyms:mafl
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-010605-3. mafaa.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202781 – 315Transcription factor MafAAdd BLAST315

Proteomic databases

PaxDbiA3KMR8.

Expressioni

Developmental stagei

During somitogenesis expressed in somitic cells.1 Publication

Gene expression databases

BgeeiENSDARG00000044155.
ExpressionAtlasiA3KMR8. baseline.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000064832.

Structurei

3D structure databases

ProteinModelPortaliA3KMR8.
SMRiA3KMR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 286bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 248Basic motifAdd BLAST26
Regioni229 – 243Interaction with DNABy similarityAdd BLAST15
Regioni251 – 272Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 189His-richAdd BLAST48

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGiKOG4196. Eukaryota.
ENOG41102C7. LUCA.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000261683.
HOVERGENiHBG000313.
InParanoidiA3KMR8.
KOiK07595.
OMAiQRHILES.
OrthoDBiEOG091G0H46.
PhylomeDBiA3KMR8.
TreeFamiTF325689.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR013592. Maf_TF_N.
IPR028562. MafA.
IPR008917. TF_DNA-bd_sf.
IPR024874. Transciption_factor_Maf_fam.
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF30. PTHR10129:SF30. 1 hit.
PfamiView protein in Pfam
PF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.

Sequencei

Sequence statusi: Complete.

A3KMR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDLAMSAE LPNSPLAIEY VNDFDLMKFE IKKEPPEADR YCHRLPPGSL
60 70 80 90 100
SSTPISTPCS SVPSSPSFCA PSPGSQPGQN LVNGVNNNNN NSGNGNNNTQ
110 120 130 140 150
GSSGKPQMED LYWIPNYQHH ISPEALNLTP EDAVEALIGN AHHHHHHHHH
160 170 180 190 200
QPYEGFRGQQ YVGEDLSAAT NGHHHPVHHH HHHHGHHAHA RLEDRFSDEQ
210 220 230 240 250
LVSMTVRELN RQLRGFSKEE VIRLKQKRRT LKNRGYAQSC RYKRVQQRHM
260 270 280 290 300
LESEKCTLQS QVEQLKQDVA RLIKERDLYK EKYEKLASRA FNGGGNTRDP
310
SSGNHVKTTS TDFFM
Length:315
Mass (Da):35,708
Last modified:April 3, 2007 - v1
Checksum:i3F8D0349E4E211CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154E → K in BAB21104 (PubMed:11134968).Curated1
Sequence conflicti164 – 165ED → KN in BAB21104 (PubMed:11134968).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006324 mRNA. Translation: BAB21104.2.
BC133072 mRNA. Translation: AAI33073.1.
PIRiJC7572.
RefSeqiNP_001076409.1. NM_001082940.2.
UniGeneiDr.83037.

Genome annotation databases

EnsembliENSDART00000064833; ENSDARP00000064832; ENSDARG00000044155.
GeneIDi100000492.
KEGGidre:100000492.

Similar proteinsi

Entry informationi

Entry nameiMAFA_DANRE
AccessioniPrimary (citable) accession number: A3KMR8
Secondary accession number(s): Q98UK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome