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Protein

V-type proton ATPase proteolipid subunit

Gene

Atp6v0c

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase proteolipid subunitUniRule annotation
Gene namesi
Name:Atp6v0cImported
ORF Names:mCG_121835Imported, mCG_12839Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88116 Atp6v0c

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalUniRule annotationAdd BLAST24
Transmembranei56 – 77HelicalUniRule annotationAdd BLAST22
Transmembranei89 – 114HelicalUniRule annotationAdd BLAST26
Transmembranei126 – 152HelicalUniRule annotationAdd BLAST27

Keywords - Cellular componenti

Membrane, VacuoleUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000024121

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 76ATP-synt_CInterPro annotationAdd BLAST60
Domaini93 – 152ATP-synt_CInterPro annotationAdd BLAST60

Sequence similaritiesi

Belongs to the V-ATPase proteolipid subunit family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0232 Eukaryota
COG0636 LUCA
HOVERGENiHBG002712
KOiK02155
OMAiDMFARGI
OrthoDBiEOG091G0U1Y

Family and domain databases

InterProiView protein in InterPro
IPR002379 ATPase_proteolipid_c-like_dom
IPR000245 ATPase_proteolipid_csu
IPR011555 ATPase_proteolipid_su_C_euk
IPR035921 F/V-ATP_Csub_sf
PfamiView protein in Pfam
PF00137 ATP-synt_C, 2 hits
PRINTSiPR00122 VACATPASE
SUPFAMiSSF81333 SSF81333, 2 hits
TIGRFAMsiTIGR01100 V_ATP_synt_C, 1 hit

Sequencei

Sequence statusi: Complete.

A3KML5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIKNNPEY SSFFGVMGAS SAMVFSAMGA AYGTAKSGTG IAAMSVMRPE
60 70 80 90 100
LIMKSIIPVV MAGIIAIYGL VVAVLIANSL TDGITLYRSF LQLGAGLSVG
110 120 130 140 150
LSGLAAGFAI GIVGDAGVRG TAQQPRLFVG MILILIFAEV LGLYGLIVAL

ILSTK
Length:155
Mass (Da):15,808
Last modified:April 3, 2007 - v1
Checksum:i880C280C5AEB0C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083129 mRNA Translation: AAH83129.2
BC099475 mRNA Translation: AAH99475.2
BC132267 mRNA Translation: AAI32268.1
BC132611 mRNA Translation: AAI32612.1
CH466533 Genomic DNA Translation: EDL13651.1
CH466606 Genomic DNA Translation: EDL22293.1
RefSeqiNP_033859.1, NM_009729.3
UniGeneiMm.294761
Mm.30155
Mm.320896

Genome annotation databases

GeneIDi11984
KEGGimmu:11984

Similar proteinsi

Entry informationi

Entry nameiA3KML5_MOUSE
AccessioniPrimary (citable) accession number: A3KML5
Secondary accession number(s): Q4KL27, Q5XK06
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health