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Protein

V-type proton ATPase proteolipid subunit

Gene

Atp6v0c

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase proteolipid subunitUniRule annotation
Gene namesi
Name:Atp6v0cImported
ORF Names:mCG_121835Imported, mCG_12839Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88116. Atp6v0c.

Subcellular locationi

  • Vacuole membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalUniRule annotationAdd BLAST24
Transmembranei56 – 77HelicalUniRule annotationAdd BLAST22
Transmembranei89 – 114HelicalUniRule annotationAdd BLAST26
Transmembranei126 – 152HelicalUniRule annotationAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, VacuoleUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000024121.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024932.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 76ATP-synt_CInterPro annotationAdd BLAST60
Domaini93 – 152ATP-synt_CInterPro annotationAdd BLAST60

Sequence similaritiesi

Belongs to the V-ATPase proteolipid subunit family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0232. Eukaryota.
COG0636. LUCA.
HOVERGENiHBG002712.
KOiK02155.
OMAiVEDNDMF.
OrthoDBiEOG091G0U1Y.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.
TIGRFAMsiTIGR01100. V_ATP_synt_C. 1 hit.

Sequencei

Sequence statusi: Complete.

A3KML5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIKNNPEY SSFFGVMGAS SAMVFSAMGA AYGTAKSGTG IAAMSVMRPE
60 70 80 90 100
LIMKSIIPVV MAGIIAIYGL VVAVLIANSL TDGITLYRSF LQLGAGLSVG
110 120 130 140 150
LSGLAAGFAI GIVGDAGVRG TAQQPRLFVG MILILIFAEV LGLYGLIVAL

ILSTK
Length:155
Mass (Da):15,808
Last modified:April 3, 2007 - v1
Checksum:i880C280C5AEB0C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083129 mRNA. Translation: AAH83129.2.
BC099475 mRNA. Translation: AAH99475.2.
BC132267 mRNA. Translation: AAI32268.1.
BC132611 mRNA. Translation: AAI32612.1.
CH466533 Genomic DNA. Translation: EDL13651.1.
CH466606 Genomic DNA. Translation: EDL22293.1.
RefSeqiNP_033859.1. NM_009729.3.
UniGeneiMm.294761.
Mm.30155.
Mm.320896.

Genome annotation databases

GeneIDi11984.
KEGGimmu:11984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083129 mRNA. Translation: AAH83129.2.
BC099475 mRNA. Translation: AAH99475.2.
BC132267 mRNA. Translation: AAI32268.1.
BC132611 mRNA. Translation: AAI32612.1.
CH466533 Genomic DNA. Translation: EDL13651.1.
CH466606 Genomic DNA. Translation: EDL22293.1.
RefSeqiNP_033859.1. NM_009729.3.
UniGeneiMm.294761.
Mm.30155.
Mm.320896.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11984.
KEGGimmu:11984.

Organism-specific databases

CTDi527.
MGIiMGI:88116. Atp6v0c.

Phylogenomic databases

eggNOGiKOG0232. Eukaryota.
COG0636. LUCA.
HOVERGENiHBG002712.
KOiK02155.
OMAiVEDNDMF.
OrthoDBiEOG091G0U1Y.

Miscellaneous databases

ChiTaRSiAtp6v0c. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024121.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.
TIGRFAMsiTIGR01100. V_ATP_synt_C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA3KML5_MOUSE
AccessioniPrimary (citable) accession number: A3KML5
Secondary accession number(s): Q4KL27, Q5XK06
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.