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A3KLR9

- A3KLR9_BOVIN

UniProt

A3KLR9 - A3KLR9_BOVIN

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Protein

Superoxide dismutase [Cu-Zn]

Gene

ECSOD

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 copper ion per subunit.UniRule annotation
  • Note: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. copper ion binding Source: RefGenome
  2. superoxide dismutase activity Source: RefGenome
  3. zinc ion binding Source: RefGenome

GO - Biological processi

  1. removal of superoxide radicals Source: RefGenome
  2. response to hypoxia Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_204534. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:ECSODImported
Synonyms:SOD3Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular matrix Source: Ensembl
  3. extracellular space Source: RefGenome
  4. extracellular vesicular exosome Source: Ensembl
  5. trans-Golgi network Source: Ensembl
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018580.

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2032.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
KOiK16627.
OMAiHPRHPGD.
OrthoDBiEOG77HDHG.
TreeFamiTF105133.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR024141. SOD_Cu/Zn_extracel.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003:SF36. PTHR10003:SF36. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3KLR9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLALLCASVV LVAYASADQI QQQMGSNTEE QIRDMHAKVT EIWQEMMQRQ
60 70 80 90 100
AAAIDPDAAL HAVCRVLPSA TLEAEQPRVS GLVLFRQLRP GALLEAFFHL
110 120 130 140 150
EGFPNEPNGT NRAIHVHQFG DLSQGCDSTG PHYNPMSVPH PQHPGDFGNF
160 170 180 190 200
AVRDGQVWKY RSGLAASLTG PHSIAGRAVV VHAGEDDMGR GGNQASLENG
210 220 230 240
NAGRRLACCV VGLCGPGPWA RQTQEHAERK KRRRESECKA V
Length:241
Mass (Da):26,177
Last modified:April 3, 2007 - v1
Checksum:iE5FA9F77770A4D49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02017144 Genomic DNA. No translation available.
AY957404 mRNA. Translation: AAY28415.1.
RefSeqiNP_001076079.1. NM_001082610.1.
XP_005207845.1. XM_005207788.1.
XP_005207846.1. XM_005207789.1.
UniGeneiBt.1616.

Genome annotation databases

EnsembliENSBTAT00000018580; ENSBTAP00000018580; ENSBTAG00000013980.
GeneIDi532481.
KEGGibta:532481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02017144 Genomic DNA. No translation available.
AY957404 mRNA. Translation: AAY28415.1 .
RefSeqi NP_001076079.1. NM_001082610.1.
XP_005207845.1. XM_005207788.1.
XP_005207846.1. XM_005207789.1.
UniGenei Bt.1616.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000018580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000018580 ; ENSBTAP00000018580 ; ENSBTAG00000013980 .
GeneIDi 532481.
KEGGi bta:532481.

Organism-specific databases

CTDi 6649.

Phylogenomic databases

eggNOGi COG2032.
GeneTreei ENSGT00530000063226.
HOGENOMi HOG000263447.
HOVERGENi HBG000062.
KOi K16627.
OMAi HPRHPGD.
OrthoDBi EOG77HDHG.
TreeFami TF105133.

Enzyme and pathway databases

Reactomei REACT_204534. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

NextBioi 20875707.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR024141. SOD_Cu/Zn_extracel.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
PANTHERi PTHR10003:SF36. PTHR10003:SF36. 1 hit.
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural studies of bovine extracellular superoxide dismutase."
    Kristensen T., Enghild J.J.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiA3KLR9_BOVIN
AccessioniPrimary (citable) accession number: A3KLR9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3