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A3KLR9

- A3KLR9_BOVIN

UniProt

A3KLR9 - A3KLR9_BOVIN

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Protein

Superoxide dismutase [Cu-Zn]

Gene
ECSOD, SOD3
Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Binds 1 copper ion per subunit By similarity.UniRule annotation
Binds 1 zinc ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. copper ion binding Source: RefGenome
  2. superoxide dismutase activity Source: RefGenome
  3. zinc ion binding Source: RefGenome

GO - Biological processi

  1. removal of superoxide radicals Source: RefGenome
  2. response to hypoxia Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_204534. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:ECSODImported
Synonyms:SOD3Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular matrix Source: Ensembl
  3. extracellular space Source: RefGenome
  4. trans-Golgi network Source: Ensembl
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018580.

Structurei

3D structure databases

ProteinModelPortaliA3KLR9.

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2032.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
InParanoidiA3KLR9.
KOiK16627.
OMAiHPRHPGD.
OrthoDBiEOG77HDHG.
TreeFamiTF105133.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR024141. SOD_Cu/Zn_extracel.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003:SF36. PTHR10003:SF36. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3KLR9-1 [UniParc]FASTAAdd to Basket

« Hide

MLALLCASVV LVAYASADQI QQQMGSNTEE QIRDMHAKVT EIWQEMMQRQ    50
AAAIDPDAAL HAVCRVLPSA TLEAEQPRVS GLVLFRQLRP GALLEAFFHL 100
EGFPNEPNGT NRAIHVHQFG DLSQGCDSTG PHYNPMSVPH PQHPGDFGNF 150
AVRDGQVWKY RSGLAASLTG PHSIAGRAVV VHAGEDDMGR GGNQASLENG 200
NAGRRLACCV VGLCGPGPWA RQTQEHAERK KRRRESECKA V 241
Length:241
Mass (Da):26,177
Last modified:April 3, 2007 - v1
Checksum:iE5FA9F77770A4D49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02017144 Genomic DNA. No translation available.
AY957404 mRNA. Translation: AAY28415.1.
RefSeqiNP_001076079.1. NM_001082610.1.
XP_005207845.1. XM_005207788.1.
XP_005207846.1. XM_005207789.1.
UniGeneiBt.1616.

Genome annotation databases

EnsembliENSBTAT00000018580; ENSBTAP00000018580; ENSBTAG00000013980.
GeneIDi532481.
KEGGibta:532481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02017144 Genomic DNA. No translation available.
AY957404 mRNA. Translation: AAY28415.1 .
RefSeqi NP_001076079.1. NM_001082610.1.
XP_005207845.1. XM_005207788.1.
XP_005207846.1. XM_005207789.1.
UniGenei Bt.1616.

3D structure databases

ProteinModelPortali A3KLR9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000018580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000018580 ; ENSBTAP00000018580 ; ENSBTAG00000013980 .
GeneIDi 532481.
KEGGi bta:532481.

Organism-specific databases

CTDi 6649.

Phylogenomic databases

eggNOGi COG2032.
GeneTreei ENSGT00530000063226.
HOGENOMi HOG000263447.
HOVERGENi HBG000062.
InParanoidi A3KLR9.
KOi K16627.
OMAi HPRHPGD.
OrthoDBi EOG77HDHG.
TreeFami TF105133.

Enzyme and pathway databases

Reactomei REACT_204534. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

NextBioi 20875707.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR024141. SOD_Cu/Zn_extracel.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
PANTHERi PTHR10003:SF36. PTHR10003:SF36. 1 hit.
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural studies of bovine extracellular superoxide dismutase."
    Kristensen T., Enghild J.J.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiA3KLR9_BOVIN
AccessioniPrimary (citable) accession number: A3KLR9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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