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A3KLR9

- A3KLR9_BOVIN

UniProt

A3KLR9 - A3KLR9_BOVIN

Protein

Superoxide dismutase [Cu-Zn]

Gene

ECSOD

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

    Cofactori

    Binds 1 copper ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. copper ion binding Source: RefGenome
    2. superoxide dismutase activity Source: RefGenome
    3. zinc ion binding Source: RefGenome

    GO - Biological processi

    1. removal of superoxide radicals Source: RefGenome
    2. response to hypoxia Source: Ensembl

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Ligandi

    CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_204534. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
    Gene namesi
    Name:ECSODImported
    Synonyms:SOD3Imported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 6

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular matrix Source: Ensembl
    3. extracellular space Source: RefGenome
    4. trans-Golgi network Source: Ensembl

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000018580.

    Structurei

    3D structure databases

    ProteinModelPortaliA3KLR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2032.
    GeneTreeiENSGT00530000063226.
    HOGENOMiHOG000263447.
    HOVERGENiHBG000062.
    InParanoidiA3KLR9.
    KOiK16627.
    OMAiHPRHPGD.
    OrthoDBiEOG77HDHG.
    TreeFamiTF105133.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR024141. SOD_Cu/Zn_extracel.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PANTHERiPTHR10003:SF36. PTHR10003:SF36. 1 hit.
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    PRINTSiPR00068. CUZNDISMTASE.
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3KLR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLALLCASVV LVAYASADQI QQQMGSNTEE QIRDMHAKVT EIWQEMMQRQ    50
    AAAIDPDAAL HAVCRVLPSA TLEAEQPRVS GLVLFRQLRP GALLEAFFHL 100
    EGFPNEPNGT NRAIHVHQFG DLSQGCDSTG PHYNPMSVPH PQHPGDFGNF 150
    AVRDGQVWKY RSGLAASLTG PHSIAGRAVV VHAGEDDMGR GGNQASLENG 200
    NAGRRLACCV VGLCGPGPWA RQTQEHAERK KRRRESECKA V 241
    Length:241
    Mass (Da):26,177
    Last modified:April 3, 2007 - v1
    Checksum:iE5FA9F77770A4D49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02017144 Genomic DNA. No translation available.
    AY957404 mRNA. Translation: AAY28415.1.
    RefSeqiNP_001076079.1. NM_001082610.1.
    XP_005207845.1. XM_005207788.1.
    XP_005207846.1. XM_005207789.1.
    UniGeneiBt.1616.

    Genome annotation databases

    EnsembliENSBTAT00000018580; ENSBTAP00000018580; ENSBTAG00000013980.
    GeneIDi532481.
    KEGGibta:532481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02017144 Genomic DNA. No translation available.
    AY957404 mRNA. Translation: AAY28415.1 .
    RefSeqi NP_001076079.1. NM_001082610.1.
    XP_005207845.1. XM_005207788.1.
    XP_005207846.1. XM_005207789.1.
    UniGenei Bt.1616.

    3D structure databases

    ProteinModelPortali A3KLR9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000018580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000018580 ; ENSBTAP00000018580 ; ENSBTAG00000013980 .
    GeneIDi 532481.
    KEGGi bta:532481.

    Organism-specific databases

    CTDi 6649.

    Phylogenomic databases

    eggNOGi COG2032.
    GeneTreei ENSGT00530000063226.
    HOGENOMi HOG000263447.
    HOVERGENi HBG000062.
    InParanoidi A3KLR9.
    KOi K16627.
    OMAi HPRHPGD.
    OrthoDBi EOG77HDHG.
    TreeFami TF105133.

    Enzyme and pathway databases

    Reactomei REACT_204534. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    NextBioi 20875707.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR024141. SOD_Cu/Zn_extracel.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    PANTHERi PTHR10003:SF36. PTHR10003:SF36. 1 hit.
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    PRINTSi PR00068. CUZNDISMTASE.
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural studies of bovine extracellular superoxide dismutase."
      Kristensen T., Enghild J.J.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LiverImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HerefordImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: HerefordImported.

    Entry informationi

    Entry nameiA3KLR9_BOVIN
    AccessioniPrimary (citable) accession number: A3KLR9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3