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Protein

Superoxide dismutase [Cu-Zn]

Gene

ECSOD

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandCopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-BTA-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:ECSODImported
Synonyms:SOD3Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501108576018 – 241Superoxide dismutase [Cu-Zn]Sequence analysisAdd BLAST224

Expressioni

Gene expression databases

BgeeiENSBTAG00000013980.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018580.

Structurei

3D structure databases

SMRiA3KLR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 211Sod_CuInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
KOiK16627.
OMAiEQEDDMG.
OrthoDBiEOG091G13ID.
TreeFamiTF105133.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiView protein in InterPro
IPR036423. SOD-like_Cu/Zn_dom_sf.
IPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiView protein in Pfam
PF00080. Sod_Cu. 1 hit.
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiView protein in PROSITE
PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A3KLR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLCASVV LVAYASADQI QQQMGSNTEE QIRDMHAKVT EIWQEMMQRQ
60 70 80 90 100
AAAIDPDAAL HAVCRVLPSA TLEAEQPRVS GLVLFRQLRP GALLEAFFHL
110 120 130 140 150
EGFPNEPNGT NRAIHVHQFG DLSQGCDSTG PHYNPMSVPH PQHPGDFGNF
160 170 180 190 200
AVRDGQVWKY RSGLAASLTG PHSIAGRAVV VHAGEDDMGR GGNQASLENG
210 220 230 240
NAGRRLACCV VGLCGPGPWA RQTQEHAERK KRRRESECKA V
Length:241
Mass (Da):26,177
Last modified:April 3, 2007 - v1
Checksum:iE5FA9F77770A4D49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02017144 Genomic DNA. No translation available.
AY957404 mRNA. Translation: AAY28415.1.
RefSeqiNP_001076079.1. NM_001082610.1.
XP_005207846.1. XM_005207789.3.
XP_015327049.1. XM_015471563.1.
UniGeneiBt.1616.

Genome annotation databases

EnsembliENSBTAT00000018580; ENSBTAP00000018580; ENSBTAG00000013980.
GeneIDi532481.
KEGGibta:532481.

Similar proteinsi

Entry informationi

Entry nameiA3KLR9_BOVIN
AccessioniPrimary (citable) accession number: A3KLR9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 22, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported