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Protein

Superoxide dismutase [Cu-Zn]

Gene

SOD3

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandCopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-BTA-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:SOD3Imported
Synonyms:ECSODImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:35126 SOD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501408357618 – 241Superoxide dismutase [Cu-Zn]Sequence analysisAdd BLAST224

Expressioni

Gene expression databases

BgeeiENSBTAG00000013980

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018580

Structurei

3D structure databases

SMRiA3KLR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 211Sod_CuInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
GeneTreeiENSGT00530000063226
HOGENOMiHOG000263447
HOVERGENiHBG000062
KOiK16627
OMAiEQEDDMG
OrthoDBiEOG091G13ID
TreeFamiTF105133

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.2001 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A3KLR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLCASVV LVAYASADQI QQQMGSNTEE QIRDMHAKVT EIWQEMMQRQ
60 70 80 90 100
AAAIDPDAAL HAVCRVLPSA TLEAEQPRVS GLVLFRQLRP GALLEAFFHL
110 120 130 140 150
EGFPNEPNGT NRAIHVHQFG DLSQGCDSTG PHYNPMSVPH PQHPGDFGNF
160 170 180 190 200
AVRDGQVWKY RSGLAASLTG PHSIAGRAVV VHAGEDDMGR GGNQASLENG
210 220 230 240
NAGRRLACCV VGLCGPGPWA RQTQEHAERK KRRRESECKA V
Length:241
Mass (Da):26,177
Last modified:April 3, 2007 - v1
Checksum:iE5FA9F77770A4D49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02017144 Genomic DNA No translation available.
AY957404 mRNA Translation: AAY28415.1
RefSeqiNP_001076079.1, NM_001082610.1
XP_005207846.1, XM_005207789.3
XP_015327049.1, XM_015471563.1
UniGeneiBt.1616

Genome annotation databases

EnsembliENSBTAT00000018580; ENSBTAP00000018580; ENSBTAG00000013980
GeneIDi532481
KEGGibta:532481

Similar proteinsi

Entry informationi

Entry nameiA3KLR9_BOVIN
AccessioniPrimary (citable) accession number: A3KLR9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported